Between- and Within-Person Effects of Alcohol and Cannabis Co-Use on Subjective Alcohol Response and Problem Drinking

酒精和大麻共同使用对主观酒精反应和饮酒问题的人际和人内影响

• 批准号: 10462319
• 负责人: Jack T Waddell
• 金额: $ 4.54万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10462319
• 关键词: Acute; Address; Affective; Alcohol abuse; Alcohol consumption; Alcoholic beverage heavy drinker; Alcohols; Arousal; Cannabis; Collaborations; Data; Dizziness; Drunk driving; Ecological momentary assessment; Event; Faculty; Feeling; Fellowship; Goals; Heavy Drinking; Impulsivity; Individual; Intervention; Intoxication; Measures; Mediating; Mediation; Mediator of activation protein; Mentors; Methodology; Methods; Modeling; Outcome; Participant; Pattern; Persons; Positioning Attribute; Reporting; Research; Research Personnel; Rewards; Risk; Risk Factors; Sexual Development; Statistical Data Interpretation; Telephone; Testing; Time; Training; Work; alcohol consequences; alcohol effect; alcohol misuse; alcohol response; alcohol risk; alcohol use disorder; base; brief intervention; career; data management; design; drinking; experience; follow up assessment; novel; preventable death; programs; response; tenure track

Project Abstract: The proposed fellowship seeks to identify whether subjective alcohol response (i.e., acute affective and intoxicating effects) serve as both between-person and within-person mechanisms of risk through which alcohol and cannabis co-use is related to heavier drinking and negative consequences. The applicant's long- term career goal is to obtain a tenure-track faculty position with a research program focused on the dynamic interplay among co-use, subjective response, and impulsivity as predictors of problem drinking. This fellowship will enable the applicant to gain expertise in subjective response to co-use, advanced quantitative analyses, as well as Ecological Momentary Assessment (EMA) data management and organization. This fellowship will also enable the applicant to develop and strengthen fruitful collaborations with leaders in the field of co-use, subjective response, and EMA methods. The current training plan features a highly skilled mentoring team with expertise in subjective alcohol response (Dr. William Corbin), advanced quantitative analyses (Dr. Kevin Grimm), subjective response to cannabis/co-use (Dr. Jane Metrik), and EMA methods of co-use (Drs. Christine Lee and Timothy Trull). The proposed project will use data from an ongoing EMA study that captures event- level data on subjective response to moments of co-use (vs. alcohol-only use), as well as same-night drinking quantity and negative consequences via a novel phone application (TigerAware). The proposed study will test 1) whether co-users (vs. alcohol-only users) endorse heightened between-person levels of subjective response (i.e., acute affective and intoxicating effects), 2) whether event-level co-use (vs. alcohol-only use) is associated with heightened within-person levels of subjective response, and 3) whether subjective response mediates the within-person effect of event-level co-use (vs alcohol-only use) on heavier drinking and negative consequences aggregated to the day-level. Participants (Current N=115; Target N=130) will come from a 21-day EMA study, in which they were asked to fill out a morning report, two afternoon reports, and three nightly reports. Participants were asked to initiate a drink report when drinking, which had follow-up assessments that replaced concurrent random reports at that time. Co-use of alcohol and cannabis was assessed during drink reports, acute subjective response was assessed during drink reports, and past-night drinking quantity and negative consequences were assessed during next-day morning reports. The proposed study will be the first to test both between-person and within-person differences in subjective response based upon co-use. It will also be the first to differentiate co-use “subjective intoxication” from several subjective response domains, which is vital to understand which acute effects are enhanced or exacerbated by co-use. Findings will inform brief interventions by better understanding 1) between-person risk factors for alcohol misuse to tailor via broad-level interventions, and 2) within-person risk factors to target via just-in-time interventions seeking to reduce alcohol misuse on riskier (i.e., co-use) days.

项目摘要： 拟议的奖学金旨在确定主观酒精反应（即，急性情感和 中毒效应）作为人与人之间和人内的风险机制， 同时使用酒精和大麻与酗酒和负面后果有关。申请人的长期- 长期职业目标是获得一个终身教职，其研究项目侧重于动态 共同使用，主观反应和冲动之间的相互作用作为问题饮酒的预测因素。该研究金基金 将使申请人获得专业知识的主观反应，共同使用，先进的定量分析， 以及生态瞬时评估（EMA）数据管理和组织。该奖学金还将 使申请人能够发展和加强与共同使用领域的领导者的富有成效的合作， 主观反应和EMA方法。目前的培训计划包括一个高技能的指导团队， 主观酒精反应的专业知识（威廉·科尔宾博士），先进的定量分析（凯文博士 Grimm）、对大麻/联合用药的主观反应（Jane Metrik博士）和EMA联合用药方法（克莉丝汀博士 Lee和Timothy特吕尔）。拟议的项目将使用正在进行的EMA研究的数据，该研究捕获事件- 对共同使用（与仅使用酒精）以及同夜饮酒的主观反应水平数据 数量和负面影响通过一个新的手机应用程序（TigerAware）。这项研究将测试 1)共同使用者（相对于仅饮酒者）是否赞同提高人与人之间的主观反应水平 (i.e.,急性情感和中毒效应），2）事件水平的共同使用（与仅使用酒精）是否相关 主观反应的人内水平提高，以及3）主观反应是否介导 事件水平共同使用（与仅使用酒精）对重度饮酒和负面后果的人内效应 汇总到日级别。受试者（当前N=115;目标N=130）将来自21天EMA研究， 要求他们填写一份上午报告，两份下午报告和三份夜间报告。 参与者被要求在饮酒时发起饮酒报告，该报告具有后续评估， 当时的随机报告。在饮酒报告中评估了酒精和大麻的共同使用， 急性主观反应在饮酒报告期间进行评估，昨晚饮酒量和阴性 在第二天早上的报告中评估结果。这项拟议中的研究将是第一次测试这两种方法 基于共同使用的主观反应的人与人之间的差异。也将是 首先区分共同使用“主观中毒”从几个主观反应域，这是至关重要的， 了解共同使用会增强或加剧哪些急性效应。调查结果将为简短的干预措施提供信息 通过更好地了解1）酒精滥用的人与人之间的风险因素， 干预措施，2）通过及时干预措施减少酒精摄入， 风险较大的误用（即，共同使用）天。