Between- and Within-Person Effects of Alcohol and Cannabis Co-Use on Subjective Alcohol Response and Problem Drinking

酒精和大麻共同使用对主观酒精反应和饮酒问题的人际和人内影响

• 批准号: 10462319
• 负责人: Jack T Waddell
• 金额: $ 4.54万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10462319
• 关键词: Acute; Address; Affective; Alcohol abuse; Alcohol consumption; Alcoholic beverage heavy drinker; Alcohols; Arousal; Cannabis; Collaborations; Data; Dizziness; Drunk driving; Ecological momentary assessment; Event; Faculty; Feeling; Fellowship; Goals; Heavy Drinking; Impulsivity; Individual; Intervention; Intoxication; Measures; Mediating; Mediation; Mediator of activation protein; Mentors; Methodology; Methods; Modeling; Outcome; Participant; Pattern; Persons; Positioning Attribute; Reporting; Research; Research Personnel; Rewards; Risk; Risk Factors; Sexual Development; Statistical Data Interpretation; Telephone; Testing; Time; Training; Work; alcohol consequences; alcohol effect; alcohol misuse; alcohol response; alcohol risk; alcohol use disorder; base; brief intervention; career; data management; design; drinking; experience; follow up assessment; novel; preventable death; programs; response; tenure track

Project Abstract: The proposed fellowship seeks to identify whether subjective alcohol response (i.e., acute affective and intoxicating effects) serve as both between-person and within-person mechanisms of risk through which alcohol and cannabis co-use is related to heavier drinking and negative consequences. The applicant's long- term career goal is to obtain a tenure-track faculty position with a research program focused on the dynamic interplay among co-use, subjective response, and impulsivity as predictors of problem drinking. This fellowship will enable the applicant to gain expertise in subjective response to co-use, advanced quantitative analyses, as well as Ecological Momentary Assessment (EMA) data management and organization. This fellowship will also enable the applicant to develop and strengthen fruitful collaborations with leaders in the field of co-use, subjective response, and EMA methods. The current training plan features a highly skilled mentoring team with expertise in subjective alcohol response (Dr. William Corbin), advanced quantitative analyses (Dr. Kevin Grimm), subjective response to cannabis/co-use (Dr. Jane Metrik), and EMA methods of co-use (Drs. Christine Lee and Timothy Trull). The proposed project will use data from an ongoing EMA study that captures event- level data on subjective response to moments of co-use (vs. alcohol-only use), as well as same-night drinking quantity and negative consequences via a novel phone application (TigerAware). The proposed study will test 1) whether co-users (vs. alcohol-only users) endorse heightened between-person levels of subjective response (i.e., acute affective and intoxicating effects), 2) whether event-level co-use (vs. alcohol-only use) is associated with heightened within-person levels of subjective response, and 3) whether subjective response mediates the within-person effect of event-level co-use (vs alcohol-only use) on heavier drinking and negative consequences aggregated to the day-level. Participants (Current N=115; Target N=130) will come from a 21-day EMA study, in which they were asked to fill out a morning report, two afternoon reports, and three nightly reports. Participants were asked to initiate a drink report when drinking, which had follow-up assessments that replaced concurrent random reports at that time. Co-use of alcohol and cannabis was assessed during drink reports, acute subjective response was assessed during drink reports, and past-night drinking quantity and negative consequences were assessed during next-day morning reports. The proposed study will be the first to test both between-person and within-person differences in subjective response based upon co-use. It will also be the first to differentiate co-use “subjective intoxication” from several subjective response domains, which is vital to understand which acute effects are enhanced or exacerbated by co-use. Findings will inform brief interventions by better understanding 1) between-person risk factors for alcohol misuse to tailor via broad-level interventions, and 2) within-person risk factors to target via just-in-time interventions seeking to reduce alcohol misuse on riskier (i.e., co-use) days.

项目摘要： 拟议的研究金旨在确定主观酒精反应(即急性情感反应和 醉人效应)既是人与人之间的风险机制，也是人与人之间的风险机制 酒精和大麻的共同使用与酗酒和消极后果有关。申请人的长- 学期的职业目标是获得一个终身教职的职位，并有一个专注于动态的研究项目 共同使用、主观反应和冲动之间的相互作用作为问题饮酒的预测因子。这一团契 将使申请人能够在共同使用的主观反应方面获得专业知识，先进的量化分析，如 以及生态瞬时评估(EMA)数据管理和组织。这一团契还将 使申请者能够与共同使用领域的领导者发展和加强富有成效的合作， 主观反应和EMA方法。目前的培训计划以一支技能精湛的指导团队为特色， 在主观酒精反应方面的专业知识(威廉·科尔宾博士)，高级定量分析(凯文博士 对大麻/联合使用的主观反应(简·梅特里克博士)和共同使用的环境管理方法(克里斯汀博士 李和蒂莫西·特鲁尔)。拟议的项目将使用EMA正在进行的一项研究的数据，该研究捕捉到了- 关于共同饮酒(与仅饮酒相比)以及当晚饮酒的主观反应的水平数据 通过一种新的手机应用程序(TigerAware)提供数量和负面后果。拟议中的研究将测试 1)共同使用者(与纯酒精使用者相比)是否认可人与人之间主观反应水平的提高 (即，急性情感和醉人效应)，2)事件级别的共同使用(与仅酒精使用相比)是否相关 主观反应的人内水平提高，以及3)主观反应是否在 事件级联合使用(与单纯饮酒相比)对酗酒和负面后果的个人影响 汇总到日级别。参与者(当前N=115；目标N=130)将来自为期21天的EMA研究， 他们被要求填写一份上午报告，两份下午报告，三份夜间报告。 参与者被要求在饮酒时发起一份饮酒报告，该报告有后续评估，取代了 当时的并发随机报告。酒精和大麻的共同使用在饮酒报告中进行了评估， 在饮酒报告中评估急性主观反应，以及昨晚饮酒量和阴性 在第二天早上的报告中对后果进行了评估。这项拟议的研究将是第一次对这两项研究进行测试 基于共同使用的主观反应的人与人之间的差异。这也将是 首先区分共同使用的“主观陶醉”和几个主观反应领域，这是至关重要的 了解联合使用会增强或加剧哪些急性影响。调查结果将为简短的干预提供依据 通过更好地了解1)人与人之间的酒精滥用风险因素，以通过广泛的水平进行定制 干预措施，以及2)通过寻求减少酒精的及时干预来针对人内的风险因素 在风险较高(即共同使用)的日子里滥用。