Characterization of socioeconomic and land use factors related to Aedes aegypti distribution in Maricopa County, Arizona

亚利桑那州马里科帕县与埃及伊蚊分布相关的社会经济和土地利用因素特征

• 批准号: 10462508
• 负责人: Whitney M Holeva-Eklund
• 金额: $ 3.72万
• 依托单位: NORTHERN ARIZONA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10462508
• 关键词: Aedes; Area; Arizona; Blood; Border Crossings; Censuses; Central America; Characteristics; Chikungunya virus; Cost of Illness; County; Coupled; Culicidae; Data; Dengue; Desert Climate; Disease; Disease Outbreaks; Ecology; Environmental Health; Genomics; Geography; Goals; Habitats; Health Sciences; Human; Infrastructure; Intervention; Laboratories; Latin America; Mexican; Mexico; Microcephaly; Mosquito Control; Mosquito-borne infectious disease; Movement; Neighborhoods; Persons; Population; Public Health; Public Health Informatics; Recommendation; Research; Research Personnel; Risk; Seasons; Socioeconomic Factors; Socioeconomic Status; Statistical Data Interpretation; Statistical Models; Temperature; Time; Travel; Vector-transmitted infectious disease; Yellow Fever; ZIKV infection; Zika Virus; base; burden of illness; career; climate change; cost; disease transmission; genome sequencing; health equity; land use; man; migration; mitochondrial genome; prevent; skills; socioeconomics; trait; transmission process; vector; vector control; vector mosquito

Project Summary Aedes aegypti mosquitoes are primary vectors of dengue, yellow fever, and the newly emerged threats of Zika and chikungunya viruses. In recent years, mosquito-borne diseases have reemerged as a pressing public health issue around the world, as the geographic range of mosquitoes has increased rapidly due to expanded global trade and travel and potentially due to increased temperatures caused by climate change. Maricopa County, Arizona is potentially at risk for developing Ae. aegypti transmitted diseases due to the established presence of the mosquito vector and the high volume of travelers coming to Arizona from areas with endemic Ae. aegypti- borne disease. In fact, on average, over 25 million travelers cross the border from Mexico (an area with diseases transmitted by the vector) into Arizona each year. Although much research exists on the wide-scale distribution of mosquito vectors, there is less understanding of the local factors that promote mosquito populations or the geographic range of the mosquitoes, especially in a desert climate. It is not known whether there are local socioeconomic or environmental characteristics that support larger Ae. aegypti populations or how mosquitoes move between local populations. We will use a combination of statistical analysis, spatial analysis, and phylogenomic analysis to develop a better understanding of the local factors that support mosquito populations and how mosquito populations are moving over time and space. The long-term goal of this project is to identify small-scale socioeconomic or landscape characteristics that consistently support Ae. aegypti populations and implement interventions with the Vector Control Division in Maricopa County, AZ to reduce mosquito populations, thereby reducing disease transmission risk. The rationale for this application is that the understanding of the distribution, range, and movement of the mosquito populations is a critical component of implementing effective public health efforts that can reduce disease burden and cost by aiming to prevent potential outbreaks of mosquito-borne disease. Hypothesis: Ae. aegypti will not be uniformly distributed throughout Maricopa County, with some areas having larger populations due to differences in infrastructure or landscape characteristics (which are related to neighborhood socioeconomic status) and therefore potential mosquito habitat. Furthermore, we hypothesize that genetically distinct populations will be separated by short distances and will be unique to specific neighborhoods. Aim 1: Characterize the neighborhood socioeconomic factors associated with Ae. aegypti abundance. Aim 2: Characterize landscape traits, such as greenness, that are associated with Ae. aegypti populations. Aim 3: Characterize the origin of and migration between local Ae. aegypti mosquito populations within Maricopa County, Arizona.

项目摘要 埃及伊蚊是登革热、黄热病和新出现的寨卡病毒威胁的主要传播媒介 和基孔肯雅病毒。近年来，蚊媒疾病再次成为一个紧迫的公共卫生问题 蚊子的地理范围由于全球范围的扩大而迅速增加， 贸易和旅行，并可能由于气候变化造成的气温上升。马奎拉县， 亚利桑那州有可能发展Ae。埃及人传播的疾病， 蚊子媒介和大量来自流行性Ae地区的旅行者来到亚利桑那州。埃及的，埃及的 传播疾病。事实上，平均而言，超过2500万游客从墨西哥（一个疾病多发地区）穿越边境 通过媒介传播）进入亚利桑那州。尽管对大范围分布的研究很多， 蚊子媒介，有较少的了解，促进蚊子种群的当地因素或 蚊子的地理范围，特别是在沙漠气候中。目前尚不清楚当地是否有 社会经济或环境特征支持较大的Ae。埃及人的种群或蚊子如何 在当地居民之间流动。我们将使用统计分析、空间分析和 进行基因组分析，以更好地了解支持蚊子种群的当地因素 以及蚊子的数量是如何随时间和空间移动的。该项目的长期目标是确定 小规模的社会经济或景观特征，一贯支持Ae。埃及人口和 与亚利桑那州马奎拉县的病媒控制部门一起实施干预措施，以减少蚊子 从而降低疾病传播风险。该应用程序的基本原理是， 了解蚊子种群的分布、范围和运动是 实施有效的公共卫生工作，通过预防和控制疾病， 蚊子传播疾病的潜在爆发。 假设：Ae。埃及人不会均匀地分布在整个马尔马拉县，有些地区 由于基础设施或景观特征的差异（与 附近的社会经济地位），因此潜在的蚊子栖息地。此外，我们假设 遗传上不同的种群将被短距离分开，并且将是特定的 邻里关系 目的1：描述与Ae相关的社区社会经济因素。埃及丰富。 目的2：描述景观特征，如绿色，与Ae。埃及人。 目的3：描述本地Ae的起源和迁移。埃及伊蚊种群 亚利桑那州的马奎拉县。