Evaluation of the Interplay between HIV and COVID-19 in a large urban safety-net HIV clinic
大型城市安全网 HIV 诊所中 HIV 和 COVID-19 之间相互作用的评估
基本信息
- 批准号:10462510
- 负责人:
- 金额:$ 80.26万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-08-01 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:2019-nCoVAdherenceAfricaAgeAnti-Retroviral AgentsAntibody ResponseAnxietyAreaAttenuatedCOVID-19COVID-19 impactCOVID-19 pandemicCOVID-19 riskCOVID-19 susceptibilityCardiovascular DiseasesCaringCessation of lifeChronic DiseaseCitiesClinicClinicalClinical InvestigatorCommunicable DiseasesCountryDataDiabetes MellitusDiseaseDisease OutbreaksEbolaEmergency department visitEnrollmentEpidemicEpidemiologistEvaluationFibrinogenFrequenciesFutureGrantHIVHIV InfectionsHealthHealth systemHealthcareHealthcare SystemsHeightHigh PrevalenceHospitalizationHousingHuman immunodeficiency virus testHypertensionImmune responseImpairmentIncidenceIndividualInpatientsInterventionLaboratoriesLinkLogisticsLow incomeLungLung diseasesMeasuresMedicalMental DepressionMental disordersMethodsNeighborhoodsOccupational HealthOutcomePatientsPersonsPharmaceutical PreparationsPopulationPredispositionPrevalenceProceduresProspective cohortProtease InhibitorProviderPublic HealthPulmonary function testsRNARegimenRegistriesReportingResearchResearch InfrastructureRespiratory DiseaseRiskRisk FactorsSARS-CoV-2 exposureSARS-CoV-2 immune responseSARS-CoV-2 immunitySARS-CoV-2 infectionSARS-CoV-2 transmissionSan FranciscoSchoolsScientistServicesSeverity of illnessShelter facilitySiteSocial BehaviorSocial DistanceSocial WorkSocial isolationSocial supportSpanish fluSpeedStressSupport SystemSystemT cell responseT-LymphocyteTelephoneTenofovirUnited StatesViralViral Load resultVirusVisitVulnerable Populationsaging populationantiretroviral therapybasecare systemsco-infectioncohortcommunity transmissioncomorbiditycoronavirus diseaseexperiencefood insecurityhealth care service utilizationimmune activationinfection rateinfection riskinsightmarginally housednovelpandemic diseasepandemic influenzapost SARS-CoV-2 infectionpost-COVID-19public health emergencypublic health relevanceremote visitresilienceresponsesafety netserosurveysevere COVID-19sexsocial stigmasubstance usetesting servicestherapeutic developmenttransmission processurgent carevaccine developmentward
项目摘要
PROJECT SUMMARY/ ABSTRACT
An unprecedented public health emergency due to the COVID-19 pandemic is unfolding worldwide and the
United States has been the epicenter of the pandemic since March 26, 2020. No prior global pandemic of
this scale has overlapped temporally with the HIV pandemic. Despite this, given the breathtaking speed at
which the pandemic has progressed, very little is known about the interplay between HIV and SARS-CoV-2
given that COVID-19 has only recently entered areas of high HIV prevalence. The COVID-19 pandemic is
threatening worldwide gains in UNAIDS 90:90:90 targets for HIV by disrupting health systems, economies, and
the health of people with HIV. San Francisco was the first city in the U.S. to impose “shelter in place”
public health measures on March 16, 2020. Given the need to limit in-person visits to counter the spread of
COVID-19, research on the impact on HIV outcomes, retention in care, and sociobehavioral outcomes will be
crucial to develop interventions to attenuate COVID-19's deleterious impact and to plan for future pandemics.
Whether people with HIV (PWH) are more or less susceptible to COVID-19 or severe disease is unknown;
some of the risk factors for severe COVID-19 (older age, cardiovascular disease, pulmonary disease) are more
prevalent among PWH but HIV medications such as tenofovir and its metabolites could be protective. PWH in
low-income settings have marginal housing and food insecurity, increasing transmission risk. Given the impact
of HIV on immune responses, it is also important to understand if PWH will have less durable immunity against
COVID-19 following infection. Finally, the impact of the COVID-19's disruption of medical and social services
for PWH needs urgent study, both during the crisis and in its aftermath, since COVID-19 has the potential to
eradicate the progress made on Ending the HIV Epidemic to date.
This proposal will answer three vital questions concerning the interplay between the two viruses. The
site of the study will be at the Ward 86 HIV Clinic, a large safety-net clinic for publicly-insured patients with HIV
in San Francisco, near the neighborhoods experiencing concentrated COVID-19 epidemics. Aim 1 will provide
novel, urgently needed insights into how SARS-CoV-2 infection risk, prevalence and clinical outcomes vary by
HIV status and/or antiretroviral regimen (i.e. tenofovir). Aim 2 will explore whether HIV infection will impair
humoral or T-cell responses to COVID-19, providing insights for therapeutic and vaccine development. Aim 3
data will evaluate the impact of disruption of healthcare and social support systems on PWH, including viral
suppression; retention in care; hospitalizations, co-morbidity outcomes, and non-COVID-19 related death;
healthcare utilization during COVID019; and socio-behavioral outcomes during and after social distancing to
assess isolation, food insecurity, stress, substance use, stigma, and resilience. Harnessing, the research
infrastructure of the UCFAR, citywide COVID-19 registries, and a large, aging population of PWH served by
the Ward 86 clinic, this grant will put immediate, high-impact studies in place to track the colliding pandemics.
项目摘要/摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Monica Gandhi其他文献
Monica Gandhi的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Monica Gandhi', 18)}}的其他基金
Unraveling the intersection of substance use, inflammation, and HIV via hair levels
通过头发水平揭示物质使用、炎症和艾滋病毒的交叉点
- 批准号:
10761023 - 财政年份:2023
- 资助金额:
$ 80.26万 - 项目类别:
Evaluation of the Impact of HIV Status on the Immune Response to mRNA COVID-19 Vaccines
评估 HIV 状态对 mRNA COVID-19 疫苗免疫反应的影响
- 批准号:
10481408 - 财政年份:2022
- 资助金额:
$ 80.26万 - 项目类别:
Evaluation of the Impact of HIV Status on the Immune Response to mRNA COVID-19 Vaccines
评估 HIV 状态对 mRNA COVID-19 疫苗免疫反应的影响
- 批准号:
10581700 - 财政年份:2022
- 资助金额:
$ 80.26万 - 项目类别:
The HIV Nexus Scholars Program: A Research Education Program for Early-Stage Investigators Working at the Intersection of Biomedical, Social/Behavioral, and Clinical Science
HIV Nexus 学者计划:针对生物医学、社会/行为和临床科学交叉领域的早期研究人员的研究教育计划
- 批准号:
10313585 - 财政年份:2021
- 资助金额:
$ 80.26万 - 项目类别:
Evaluation of the Interplay between HIV and COVID-19 in a large urban safety-net HIV clinic
大型城市安全网 HIV 诊所中 HIV 和 COVID-19 之间相互作用的评估
- 批准号:
10169797 - 财政年份:2020
- 资助金额:
$ 80.26万 - 项目类别:
Urine tenofovir point-of-care test to identify patients in need of ART adherence support
尿液替诺福韦即时检测可识别需要 ART 依从性支持的患者
- 批准号:
10211122 - 财政年份:2020
- 资助金额:
$ 80.26万 - 项目类别:
Objective measures of adherence for later-stage ART failure in resource limited settings
在资源有限的环境中对后期 ART 失败的依从性进行客观测量
- 批准号:
10012880 - 财政年份:2020
- 资助金额:
$ 80.26万 - 项目类别:
Urine tenofovir point-of-care test to identify patients in need of ART adherence support
尿液替诺福韦即时检测可识别需要 ART 依从性支持的患者
- 批准号:
9983237 - 财政年份:2020
- 资助金额:
$ 80.26万 - 项目类别:
Evaluation of the Interplay between HIV and COVID-19 in a large urban safety-net HIV clinic
大型城市安全网 HIV 诊所中 HIV 和 COVID-19 之间相互作用的评估
- 批准号:
10669735 - 财政年份:2020
- 资助金额:
$ 80.26万 - 项目类别:
Evaluation of the Interplay between HIV and COVID-19 in a large urban safety-net HIV clinic
大型城市安全网 HIV 诊所中 HIV 和 COVID-19 之间相互作用的评估
- 批准号:
10224038 - 财政年份:2020
- 资助金额:
$ 80.26万 - 项目类别:
相似海外基金
Culturally Tailored Nutrition Therapy To Improve Dietary Adherence of Type 2 Diabetes Patients in Benin, Africa
根据文化量身定制的营养疗法可提高非洲贝宁 2 型糖尿病患者的饮食依从性
- 批准号:
10588573 - 财政年份:2022
- 资助金额:
$ 80.26万 - 项目类别:
Culturally Tailored Nutrition Therapy To Improve Dietary Adherence of Type 2 Diabetes Patients in Benin, Africa
根据文化量身定制的营养疗法可提高非洲贝宁 2 型糖尿病患者的饮食依从性
- 批准号:
10706336 - 财政年份:2022
- 资助金额:
$ 80.26万 - 项目类别:
Adherence to HIV Treatment Postpartum: The Implications of Transitions Among Women Living with HIV in South Africa
产后坚持艾滋病毒治疗:南非艾滋病毒感染妇女转变的影响
- 批准号:
10582926 - 财政年份:2022
- 资助金额:
$ 80.26万 - 项目类别:
Adaptive evaluation of mHealth and conventional adherence support interventions to optimize outcomes with new treatment regimens for drug-resistant tuberculosis and HIV in South Africa
对移动医疗和传统依从性支持干预措施进行适应性评估,以优化南非耐药结核病和艾滋病毒新治疗方案的结果
- 批准号:
10589840 - 财政年份:2022
- 资助金额:
$ 80.26万 - 项目类别:
Adaptive evaluation of mHealth and conventional adherence support interventions to optimize outcomes with new treatment regimens for drug-resistant tuberculosis and HIV in South Africa
对移动医疗和传统依从性支持干预措施进行适应性评估,以优化南非耐药结核病和艾滋病毒新治疗方案的结果
- 批准号:
10484620 - 财政年份:2022
- 资助金额:
$ 80.26万 - 项目类别:
The Role of an Artificially Intelligent Chatbot in Social Support, Antiretroviral Adherence, and Depressive Symptoms among Young Adults Living with HIV in South Africa
人工智能聊天机器人在南非艾滋病毒感染者的社会支持、抗逆转录病毒药物依从性和抑郁症状中的作用
- 批准号:
9925884 - 财政年份:2020
- 资助金额:
$ 80.26万 - 项目类别:
Community tenofovir levels as a population adherence measure to understand the impact of oral PrEP on HIV acquisition among young women in sub-Saharan Africa
社区替诺福韦水平作为人口依从性衡量标准,以了解口服 PrEP 对撒哈拉以南非洲年轻女性感染艾滋病毒的影响
- 批准号:
10028436 - 财政年份:2020
- 资助金额:
$ 80.26万 - 项目类别:
The Role of an Artificially Intelligent Chatbot in Social Support, Antiretroviral Adherence, and Depressive Symptoms among Young Adults Living with HIV in South Africa
人工智能聊天机器人在南非艾滋病毒感染者的社会支持、抗逆转录病毒药物依从性和抑郁症状中的作用
- 批准号:
10251005 - 财政年份:2020
- 资助金额:
$ 80.26万 - 项目类别:
Community tenofovir levels as a population adherence measure to understand the impact of oral PrEP on HIV acquisition among young women in sub-Saharan Africa
社区替诺福韦水平作为人口依从性衡量标准,以了解口服 PrEP 对撒哈拉以南非洲年轻女性感染艾滋病毒的影响
- 批准号:
10265507 - 财政年份:2020
- 资助金额:
$ 80.26万 - 项目类别:
Simplifying HIV Treatment and Monitoring (STREAM2): Point-of-Care Urine Tenofovir Adherence and Viral Load Testing to Improve HIV Outcomes in South Africa
简化艾滋病毒治疗和监测 (STREAM2):护理点尿液替诺福韦依从性和病毒载量检测,以改善南非的艾滋病毒治疗结果
- 批准号:
10203799 - 财政年份:2019
- 资助金额:
$ 80.26万 - 项目类别:














{{item.name}}会员




