University of Washington (UW) Sexually Transmitted Infections (STI) Cooperative Research Center (CRC) - Syphilis Vaccine to Protect against Local and Disseminated T. pallidum Infection
华盛顿大学 (UW) 性传播感染 (STI) 合作研究中心 (CRC) - 梅毒疫苗可预防局部和播散性梅毒螺旋体感染
基本信息
- 批准号:10461735
- 负责人:
- 金额:$ 203.89万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-08-01 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:AdjuvantAnimal ModelAnimalsAntibody ResponseAntigensAwardB-LymphocytesBasic ScienceBiopsyBlood - brain barrier anatomyBlood CirculationClinicClinicalClinical TrialsCommunicable DiseasesCongenital SyphilisDevelopmentDiseaseEndotheliumEpitope MappingEpitopesFailureFormulationFred Hutchinson Cancer Research CenterGenomicsGlobus PallidusGoalsGrantHumanHuman papillomavirus HPV L1 proteinImmune responseImmunityImmunizationImmunization ProgramsImmunologistIncidenceInfectionInvestigationLaboratoriesLeadershipLesionMeasuresMediatingMembrane ProteinsMentorsModelingMucous MembraneMusNeurosyphilisOryctolagus cuniculusPatientsPenicillinsPersonsPhasePlayPositioning AttributePredispositionPreventive vaccineProgram Research Project GrantsProtein FamilyProteinsPublic HealthRecombinant ProteinsResearchResearch PersonnelResearch Project GrantsRoleSamplingSanitationSexually Transmitted DiseasesSkinSurfaceSurface AntigensSyphilisSyphilitic chancreT cell responseT-LymphocyteTestingTrainingTranslational ResearchTreponema pallidumUnited StatesUniversitiesVaccinatedVaccine AdjuvantVaccine AntigenVaccinesVertical Disease TransmissionViralWashingtonbaseclinical infrastructurecombatdesignexperienceimmunogenicityimprovedmembermen who have sex with mennovel strategiesparticlepre-clinicalpreclinical studypreventrecruitresponsesyphilis vaccinevaccine candidatevaccine developmentvaccine trial
项目摘要
ABSTRACT
The overarching goal of this Sexually Transmitted Infection Cooperative Research Center (STI CRC)
proposal is to develop a candidate vaccine that provides significant protection against T. pallidum infection,
the agent that causes syphilis. Despite susceptibility to penicillin, syphilis remains a public health threat
worldwide, with an estimated 11 million new infections per year and a global burden of 36 million infections.
In the last decade, there has been a resurgence of syphilis, with near doubling of rates among men who
have sex with men and rates of congenital syphilis, resulting from mother to child transmission. As such, an
effective prophylactic vaccine is required for control in addition to standard public health measures.
The University of Washington has a long tradition of outstanding syphilis research: the research team
assembled for this proposal has developed preclinical vaccine candidates that have substantial protection in
the rabbit model. We propose three inter-related Scientific Projects. In Project 1, we will further refine the T.
pallidum Tp0751 protein, which is essential for spread of T. pallidum through the bloodstream, for use as a
vaccinogen by optimizing the protein formulation and the mode of delivery of this vaccinogen. In Project 2,
we will optimize the TprK, and TprC/D2 proteins for vaccine use, as in animal models immunity to these
antigens prevents chancre formation; optimization of these proteins will encompass protective epitope
identification as well as optimal delivery of these epitopes. Subsequently, we will test the combined
protective capacity of a vaccine cocktail comprised of these proteins in the syphilis rabbit model. In Project
3, we examine the B and T cell responses raised against the Tp0751 and Tpr vaccinogens in natural
infection in humans and in vaccinated animals. As adjuvants that evoke immunity in rabbits differ from
human-use adjuvants, we will also test the candidate vaccine adjuvanted with human track adjuvants in
mouse immunogenicity studies as a prelude to human trials.
The Scientific Projects will be supported by three Cores comprised of the Administrative Core, the Clinical
and Statistical Core, and the Genomics and Isolation Core; the Developmental Research Project Program
will provide mentoring and training to outstanding new investigators in the STI research field. By the end of
the 5 year grant timeframe we propose to have a candidate vaccine that is ready for human trials.
摘要
这个性传播感染合作研究中心的首要目标是
一项提议是开发一种候选疫苗,对梅毒螺旋体感染提供显著保护,
导致梅毒的药剂。尽管对青霉素敏感,梅毒仍然是公共健康的威胁。
据估计,全世界每年新增感染1100万人,全球感染人数为3600万人。
在过去的十年里,梅毒卷土重来,男性梅毒发病率几乎翻了一番
与男性发生性行为和因母婴传播而导致的先天性梅毒发病率。因此,一个
除了标准的公共卫生措施外,还需要有效的预防性疫苗进行控制。
华盛顿大学在梅毒研究方面有着悠久的传统:研究团队
为这项提案而聚集的已经开发出临床前候选疫苗,这些候选疫苗在
兔子模型。我们提出了三个相互关联的科学项目。在项目1中,我们将进一步细化T。
梅毒Tp0751蛋白,对梅毒螺旋体通过血液传播是必不可少的,用作
通过优化这种疫苗原的蛋白质配方和递送方式,获得了一种新型的疫苗原。在项目2中,
我们将优化TprK和TprC/D2蛋白用于疫苗,就像在动物模型中对这些免疫
抗原可防止下巴形成;这些蛋白质的优化将包括保护性表位。
这些表位的鉴定以及最佳递送。随后,我们将测试合并后的
由这些蛋白质组成的疫苗鸡尾酒在梅毒兔模型中的保护能力。在项目中
3,我们检测了在自然条件下对Tp0751和Tpr疫苗原产生的B和T细胞反应。
在人类和接种疫苗的动物中的感染。作为激发兔免疫的佐剂不同于
人用佐剂,我们还将测试用人用佐剂佐剂的候选疫苗在
小鼠免疫原性研究作为人体试验的前奏。
科学项目将得到三个核心的支持,包括行政核心、临床
和统计核心,基因组学和隔离核心;发展研究项目计划
将为STI研究领域的杰出新研究者提供指导和培训。到年底的时候
在5年的拨款时间框架内,我们建议拥有一种可用于人体试验的候选疫苗。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Anna Wald其他文献
Anna Wald的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Anna Wald', 18)}}的其他基金
University of Washington (UW) Sexually Transmitted Infections (STI) Cooperative Research Center (CRC) - Syphilis Vaccine to Protect against Local and Disseminated T. pallidum Infection
华盛顿大学 (UW) 性传播感染 (STI) 合作研究中心 (CRC) - 梅毒疫苗可预防局部和播散性梅毒螺旋体感染
- 批准号:
10671505 - 财政年份:2019
- 资助金额:
$ 203.89万 - 项目类别:
University of Washington (UW) Sexually Transmitted Infections (STI) Cooperative Research Center (CRC) - Syphilis Vaccine to Protect against Local and Disseminated T. pallidum Infection
华盛顿大学 (UW) 性传播感染 (STI) 合作研究中心 (CRC) - 梅毒疫苗可预防局部和播散性梅毒螺旋体感染
- 批准号:
10219118 - 财政年份:2019
- 资助金额:
$ 203.89万 - 项目类别:
University of Washington (UW) Sexually Transmitted Infections (STI) Cooperative Research Center (CRC) - Syphilis Vaccine to Protect against Local and Disseminated T. pallidum Infection
华盛顿大学 (UW) 性传播感染 (STI) 合作研究中心 (CRC) - 梅毒疫苗可预防局部和播散性梅毒螺旋体感染
- 批准号:
10772345 - 财政年份:2019
- 资助金额:
$ 203.89万 - 项目类别:
University of Washington (UW) Sexually Transmitted Infections (STI) Cooperative Research Center (CRC) - Syphilis Vaccine to Protect against Local and Disseminated T. pallidum Infection
华盛顿大学 (UW) 性传播感染 (STI) 合作研究中心 (CRC) - 梅毒疫苗可预防局部和播散性梅毒螺旋体感染
- 批准号:
9982766 - 财政年份:2019
- 资助金额:
$ 203.89万 - 项目类别:
University of Washington (UW) Sexually Transmitted Infections (STI) Cooperative Research Center (CRC) - Syphilis Vaccine to Protect against Local and Disseminated T. pallidum Infection
华盛顿大学 (UW) 性传播感染 (STI) 合作研究中心 (CRC) - 梅毒疫苗可预防局部和播散性梅毒螺旋体感染
- 批准号:
10544247 - 财政年份:2019
- 资助金额:
$ 203.89万 - 项目类别:
相似海外基金
Quantification of Neurovasculature Changes in a Post-Hemorrhagic Stroke Animal-Model
出血性中风后动物模型中神经血管变化的量化
- 批准号:
495434 - 财政年份:2023
- 资助金额:
$ 203.89万 - 项目类别:
Bioactive Injectable Cell Scaffold for Meniscus Injury Repair in a Large Animal Model
用于大型动物模型半月板损伤修复的生物活性可注射细胞支架
- 批准号:
10586596 - 财政年份:2023
- 资助金额:
$ 203.89万 - 项目类别:
A Comparison of Treatment Strategies for Recovery of Swallow and Swallow-Respiratory Coupling Following a Prolonged Liquid Diet in a Young Animal Model
幼年动物模型中长期流质饮食后吞咽恢复和吞咽呼吸耦合治疗策略的比较
- 批准号:
10590479 - 财政年份:2023
- 资助金额:
$ 203.89万 - 项目类别:
Small animal model for evaluating the impacts of cleft lip repairing scar on craniofacial growth and development
评价唇裂修复疤痕对颅面生长发育影响的小动物模型
- 批准号:
10642519 - 财政年份:2023
- 资助金额:
$ 203.89万 - 项目类别:
Diurnal grass rats as a novel animal model of seasonal affective disorder
昼夜草鼠作为季节性情感障碍的新型动物模型
- 批准号:
23K06011 - 财政年份:2023
- 资助金额:
$ 203.89万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Longitudinal Ocular Changes in Naturally Occurring Glaucoma Animal Model
自然发生的青光眼动物模型的纵向眼部变化
- 批准号:
10682117 - 财政年份:2023
- 资助金额:
$ 203.89万 - 项目类别:
A whole animal model for investigation of ingested nanoplastic mixtures and effects on genomic integrity and health
用于研究摄入的纳米塑料混合物及其对基因组完整性和健康影响的整体动物模型
- 批准号:
10708517 - 财政年份:2023
- 资助金额:
$ 203.89万 - 项目类别:
A Novel Large Animal Model for Studying the Developmental Potential and Function of LGR5 Stem Cells in Vivo and in Vitro
用于研究 LGR5 干细胞体内外发育潜力和功能的新型大型动物模型
- 批准号:
10575566 - 财政年份:2023
- 资助金额:
$ 203.89万 - 项目类别:
Elucidating the pathogenesis of a novel animal model mimicking chronic entrapment neuropathy
阐明模拟慢性卡压性神经病的新型动物模型的发病机制
- 批准号:
23K15696 - 财政年份:2023
- 资助金额:
$ 203.89万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
The effect of anti-oxidant on swallowing function in an animal model of dysphagia
抗氧化剂对吞咽困难动物模型吞咽功能的影响
- 批准号:
23K15867 - 财政年份:2023
- 资助金额:
$ 203.89万 - 项目类别:
Grant-in-Aid for Early-Career Scientists














{{item.name}}会员




