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中文摘要
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摘要 华盛顿大学(UW)STI CRC的临床和统计核心位于专门的 位于UW-Harborview医疗中心新建大楼11楼的临床研究空间 传染病研究诊所(Infectious Diseases Research Clinic)研究临床医生和协调员谁在工作, Research Clinic拥有多年的性传播感染相关研究经验,并与 性病诊所我们的目标是:临床和统计核心将招募,评估和保留参与者, 为项目3的研究提供临床标本,并提供数据管理、功效计算和 分析项目1、2和3中产生的实验。此外,该核心将与 基因组学和分离核心完成测序分析。这些团队有着 在以前的病原体测序研究中,共同管理样本跟踪和数据存储。 基因组学和分离核心的生物信息学管道将提供临床和统计核心 与组装的、比对的、注释的序列一起用于进一步分析。 临床和统计核心还通过遵守研究,确保为所有项目收集的数据的完整性。 程序和促进人类受试者研究的最高标准,包括遵守良好的 临床实践。核心小组还确认,研究设计和分析技术得到了优化, 允许最稳健的实验和结果的解释。尸体僵硬是基于 分析计划,遵守这些计划,以及报告所进行分析的透明度。
英文摘要
ABSTRACT The Clinical and Statistical Core for the University of Washington (UW) STI CRC is located in dedicated clinical research space on the 11th floor of a newly constructed building on the UW-Harborview Medical Center campus, the Infectious Diseases Research Clinic. The research clinicians and coordinators who work at the Research Clinic have many years of experience in STI-related research, and there is close collaboration with the STD clinic. Our aims are: The Clinical and Statistical Core will recruit, evaluate and retain participants to provide clinical specimens for study in Project 3, and provide data management, power calculations and analysis for experiments generated in Projects 1, 2 and 3. In addition, this Core will work closely with the Genomics and Isolation Core to complete sequencing analyses. These teams have a history of working together in previous studies of pathogen sequencing, jointly managing specimen tracking and data storage. The bioinformatic pipeline of the Genomics and Isolation Core will provide the Clinical and Statistical Core with assembled, aligned, annotated sequences for further analyses. The Clinical and Statistical Core also ensures the integrity of data collected for all Projects by adhering to study procedures and promoting the highest standards of human subjects research, including adherence to Good Clinical Practices. The Core also ascertains that the study design and analytical techniques are optimized to permit the most robust experiments and interpretation of the results. Rigor is based on careful preparation of analysis plans, adherence to such plans, and transparency in reporting the conducted analyses.
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Administrative Core
  • 批准号:
    9982771
  • 项目类别:
  • 资助金额:
    $45.54万
  • 财政年份:
    2019
  • 负责人:
    Anna Wald
  • 依托单位:
海外基金