Biomarkers of Developmental Language Disorder and Their Relationship to Language Impairment

发育性语言障碍的生物标志物及其与语言障碍的关系

• 批准号: 10464825
• 负责人: Noelle Abbott
• 金额: $ 3.65万
• 依托单位: SAN DIEGO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10464825
• 关键词: Address; Adult; Affect; Age; Architecture; Area; Behavior; Biological Markers; Brain; Brain region; Cerebrovascular Circulation; Child; Childhood; Comprehension; Development; Disease; Dyslexia; Environmental Risk Factor; Evaluation; Exhibits; Fellowship; Functional disorder; Genetic; Goals; Institution; Intellectual functioning disability; Intervention; Knowledge; Language; Language Development Disorders; Language Disorders; Lead; Linguistics; Link; Magnetic Resonance Imaging; Measures; Mentors; Methods; Mission; National Institute on Deafness and Other Communication Disorders; Nature; Nervous System Trauma; Neurodevelopmental Disorder; Neurologic; Outcome; Participant; Pattern; Persons; Pervasive Development Disorder; Population; Prevalence; Production; Publishing; Research; Resources; Rest; Sign Language; Source; Structure; Training; Work; arterial spin labeling; autism spectrum disorder; behavioral impairment; experience; functional outcomes; hearing impairment; improved; innovation; insight; interest; language impairment; language processing; neurobiological mechanism; neuroimaging; neurophysiology; novel strategies; peer; psychosocial; socioeconomics

Project Summary/Abstract The goal of the proposed fellowship is to explore the relationship between brain function and language impairment in children with Developmental Language Disorder (DLD) by investigating two measures of brain function, cerebral blood flow (CBF) and functional connectivity. DLD is a pervasive developmental disorder with childhood onset that can persist into adulthood and affect psychosocial relationships and socioeconomic outcomes, yet little is understood about the brain correlates of DLD. It is believed that some combination of genetic and environmental factors influences brain development in this population, but the relatively few neuroimaging studies have revealed inconsistencies regarding the ways in which these factors contribute to language impairment. We argue that functional brain differences may underlie these discrepancies. Therefore, the research proposed here addresses the critical need to better characterize the underlying neurobiological mechanisms that contribute to language impairment in children with DLD. In alignment with the NIDCD’s mission, this project seeks to identify biomarkers of DLD that can inform development of targeted interventions aimed at improving the functional outcomes for people with DLD. This will be achieved by comparing resting state CBF patterns in children with DLD (ages 9-11) to typically developing (TD) age-matched peers (Aim 1). Currently there are only a handful of studies that have investigated CBF in DLD, but these studies had poorly matched participants and used invasive and spatially limited methods. To our knowledge, this project will be the first to utilize arterial spin labeling, a non-invasive method for capturing whole brain CBF patterns. In addition, we will compare intrinsic functional connectivity (iFC) patterns within the language network in these two groups using functional connectivity MRI (Aim 2). To date, there are no studies that have investigated iFC in DLD, yet this method has revealed relationships between altered functional architecture and behavior in other neurodiverse populations, making it reasonable to suspect that children with DLD may also demonstrate a similar relationship. Finally, we will compare the relationship between the two measures from aims 1 and 2 to scores on linguistic and non-linguistic assessments to determine if they are related to language behavior (Aim 3). We will also investigate whether there is a correlation between CBF and functional connectivity patterns, as research has revealed that some neurodiverse populations demonstrate deviations in these patterns when compared to neurotypical populations. The proposed research will provide a novel approach to understanding the connection between underlying brain function and language behavior in DLD. The applicant’s experienced training team and available resources through two highly productive research institutions and mentoring labs, make them well- suited for completing the proposed research and contributing important findings to a critical and understudied area of research.

项目总结/摘要 该奖学金的目标是探索大脑功能和语言之间的关系 发展性语言障碍（DLD）儿童的功能障碍，通过调查两项措施， 脑功能、脑血流量（CBF）和功能连接。DLD是一种广泛性发育障碍 儿童期发病，可持续到成年，并影响心理社会关系和社会经济 结果，但对DLD的大脑相关性知之甚少。据信， 遗传和环境因素影响这一人群的大脑发育，但相对较少的是， 神经影像学研究揭示了关于这些因素如何影响神经功能的不一致性， 语言障碍我们认为，大脑功能的差异可能是这些差异的基础。因此，我们认为， 这里提出的研究解决了更好地表征潜在神经生物学特性的迫切需要， 导致DLD儿童语言障碍的机制。为了配合国家防治荒漠化和干旱研究所的使命， 该项目旨在确定DLD的生物标志物，这些生物标志物可以为制定有针对性的干预措施提供信息， 改善DLD患者的功能结果。这将通过比较静息状态CBF DLD儿童（9-11岁）与典型发育（TD）年龄匹配的同龄人（目标1）的模式。目前 只有少数研究调查了DLD中的CBF，但这些研究的匹配性很差， 参与者和使用侵入性和空间有限的方法。据我们所知，该项目将是第一个 利用动脉自旋标记，一种用于捕获全脑CBF模式的非侵入性方法。此外，我们将 比较这两组中语言网络内的内在功能连接（iFC）模式， 功能连接MRI（Aim 2）。到目前为止，还没有研究在DLD中调查iFC，但是， 这种方法揭示了其他神经多样性疾病中改变的功能结构和行为之间的关系。 因此，有理由怀疑DLD儿童也可能表现出类似的关系。 最后，我们将比较目标1和目标2中的两个指标与语言学成绩之间的关系 和非语言评估，以确定它们是否与语言行为有关（目标3）。我们还将 研究CBF和功能连接模式之间是否存在相关性， 揭示了一些神经多样性人群在这些模式中表现出偏差， 典型人群。这项研究将为理解这种联系提供一种新的方法 潜在的大脑功能和语言行为之间的联系申请人经验丰富的培训团队和 通过两个高生产力的研究机构和指导实验室的可用资源，使他们很好- 适合完成拟议的研究，并为一个关键的和未充分研究的 研究领域。