FASEB Science Research Conference: Protein Kinases and Protein Phosphorylation

FASEB 科学研究会议：蛋白激酶和蛋白磷酸化

• 批准号: 10464756
• 负责人: Alex Toker
• 金额: $ 0.35万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10464756
• 关键词: Area; Biochemical; Biochemistry; Biological Process; Biology; Canada; Career Mobility; Cellular biology; Chemicals; Clinical; Collaborations; Communication; Data; Development; Diabetes Mellitus; Diagnosis; Discipline; Disease; Disease model; Drug Industry; Drug Targeting; Educational workshop; Event; FDA approved; Faculty; Fertilization; Fostering; Funding; Future; Goals; Growth and Development function; Health; Human; Inflammation; Inflammatory; Island; Knowledge; Lighting; Link; Malignant Neoplasms; Mediating; Medicine; Mentors; Metabolic Diseases; Metabolic syndrome; Methodology; Methods; Mining; Molecular; Normal Cell; Nova Scotia; Oncology; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotransferases; Play; Prevention; Principal Investigator; Process; Protein Engineering; Protein Kinase; Protein Kinase Protein Phosphorylation; Protein phosphatase; Proteome; Reporting; Research; Research Personnel; Role; Science; Scientist; Senior Scientist; Signal Transduction; Site; Structure; Structure-Activity Relationship; Students; System; Systems Biology; Technology; Time; Translational Research; Underrepresented Minority; Underrepresented Populations; Woman; career; career development; forging; frontier; human disease; improved; in vivo Model; innovation; insight; interest; kinase inhibitor; meetings; minority scientist; multidisciplinary; next generation; novel; novel anticancer drug; novel therapeutics; posters; programs; recruit; social; structural biology; summer research; symposium; therapeutic development; therapeutic target

Program Director/Principal Investigator (Last, First, Middle): Toker, A./Bennett, A. Protein phosphorylation is vitally important in the molecular communications that control cellular state and activity. It is a dynamic process mediated by kinases and phosphatases that are precisely regulated in normal cells, and deregulated in many human diseases, including diabetes, inflammatory disease and cancer. The study of the protein phosphorylation machinery and its function in signaling systems is a robustly active area of research that has driven methodological and conceptual advances and is increasingly contributing to the development of therapeutic options. Protein kinases are frequently deregulated in cancer, and they have been the focus of intense recent interest by the pharmaceutical industry. Indeed, most new cancer drugs approved by the FDA in the last several years target kinases, and there are hundreds of new kinase inhibitors under development. This strong clinical connection provides an exciting link with translational science. In this application, we request funds to support attendance of trainees, junior faculty and traditionally underrepresented groups at the 2022 FASEB Summer Research conference on Protein Kinases and Protein Phosphorylation. This biennial conference started in 1983, and is an important interdisciplinary gathering that brings together scientists with diverse expertise to advance understanding of the biochemical mechanisms and fundamental principles of phosphorylation events – a focus that distinguishes this meeting from others that deal with signaling networks and systems approaches. This FASEB meeting has been, and continues to be, a primary venue for the announcement of breakthroughs in the field, and has a long-standing goal to enhance, and disseminate, knowledge that will lead to improved therapies to target aberrant kinase activity, and protein phosphorylation, in human disease. The 2022 FASEB Science Research Conference on Protein Kinases and Protein Phosphorylation aims to highlight recent, cutting-edge findings in the field of protein phosphorylation, to bring together structural biology, biochemistry, systems biology, chemical biology, protein engineering, and medicine. This will promote cross-fertilization among these normally separate disciplines to stimulate new lines of research, as well as to enhance communication, collaboration, career advancement for the diverse scientists in the field. The ultimate goal is to advance the field to obtain better understandings of the molecular mechanisms that regulate important biological processes and facilitate the identification of critical targets for the diagnosis, prevention, treatment, and cure of human diseases. OMB No. 0925-0001/0002 (Rev. 01/18 Approved Through 03/31/2020) Page Continuation Format Page

项目总监/首席研究员（最后、第一、中间）：Toker, A./Bennett, A. 蛋白质磷酸化对于控制细胞状态的分子通讯至关重要 活动。这是一个由激酶和磷酸酶介导的动态过程，在正常情况下受到精确调节。 细胞，并在许多人类疾病中失调，包括糖尿病、炎症性疾病和癌症。研究 蛋白质磷酸化机制及其在信号系统中的功能是一个非常活跃的领域 研究推动了方法论和概念的进步，并日益为 制定治疗方案。蛋白激酶在癌症中经常失调，并且它们已被 制药行业最近强烈关注的焦点。事实上，大多数新的抗癌药物都获得了批准 FDA 在过去几年中以激酶为目标，并且有数百种新的激酶抑制剂正在研究中 发展。这种强大的临床联系为转化科学提供了令人兴奋的联系。 在此申请中，我们请求资金来支持学员、初级教员和传统教员的出席 2022 年 FASEB 夏季蛋白激酶和蛋白质研究会议上代表性不足的群体 磷酸化。该会议每两年举办一次，始于1983年，是一次重要的跨学科聚会， 汇集具有不同专业知识的科学家，以增进对生化机制的理解和 磷酸化事件的基本原则——这是本次会议与其他会议不同的焦点 与信令网络和系统方法。这次 FASEB 会议已经并将继续是一次主要会议 宣布该领域突破的场所，并有一个长期的增强目标，以及 传播知识，从而改进针对异常激酶活性和蛋白质的治疗方法 磷酸化，在人类疾病中。 2022年FASEB蛋白激酶和蛋白质科学研究会议 蛋白质磷酸化旨在突出蛋白质磷酸化领域的最新前沿发现，以 将结构生物学、生物化学、系统生物学、化学生物学、蛋白质工程和 药品。这将促进这些通常独立的学科之间的交叉受精，以刺激新的品系 的研究，以及加强不同科学家的沟通、合作和职业发展 在外地。最终目标是推动该领域的发展，以获得对分子机制的更好理解 调节重要的生物过程并促进诊断关键目标的识别， 预防、治疗和治愈人类疾病。 OMB 编号 0925-0001/0002（修订版 01/18 批准至 03/31/2020） 页面延续格式页面