Circuit dynamics underlying perceptual learning in the functionally organized visual cortex
功能组织的视觉皮层感知学习的回路动力学
基本信息
- 批准号:10464735
- 负责人:
- 金额:$ 6.98万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-04-01 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:AcetylcholineAddressAdultArchitectureAttentionAwardBehavioralBrainCalciumChronicDataDendritic SpinesDevelopmentDiscriminationDiscrimination LearningElementsEnhancersExhibitsFloridaFoundationsFunctional ImagingFutureGeneticHeadImageImaging TechniquesIndividualInjuryInstitutesLeadLearningLearning DisabilitiesMammalsMapsModelingMolecularMonitorNatureNeuronsNeurosciencesOpticsPerceptionPerceptual learningPerformancePhasePopulationPositioning AttributePrimatesProcessPropertyPsychological reinforcementRecoveryResearchRewardsSensoryShapesSignal TransductionSpecificityStimulusStrokeStructureSynapsesSynaptic plasticityTask PerformancesTechnical ExpertiseTechniquesTechnologyTrainingTupaiaTupaiidaeV1 neuronVisualVisual Cortexarea V1area striatabasecholinergiccollaborative environmentexcitatory neuronexperienceexperimental studyflexibilityin vivo calcium imagingindividual responseinhibitory neuroninnovationlearning progressionneural circuitnovelnovel strategiesorientation selectivityprogramsrecruitrelating to nervous systemresponsesensorskillsspatiotemporaltraining opportunitytwo-photonvisual stimulus
项目摘要
Project Summary
Experience shapes cortical sensory representations in a remarkable manner during development, but after
maturation capacity for plasticity becomes limited. The tightly regulated plasticity of the mature cortex enables
learning but impedes the brain’s capacity to regain appropriate function after injury, stroke or prolonged sensory
loss. Studying mechanisms that underlie perceptual learning in the adult stage will advance our understanding
of perception and will provide the foundation to develop novel approaches that promote plasticity in the adult
brain. Recent studies in the tree shrew (tupaia belangeri), a highly visual mammal that shares cortical
organization features with primates, show that learning a reward-based orientation discrimination task leads to
long lasting changes in excitatory responses that increase discriminability between task relevant stimuli in the
mature primary visual cortex (V1). However, we lack a clear understanding of the underlying circuit mechanisms
that are responsible for these changes. I will combine my previous experience studying mechanisms of synaptic
plasticity with new training focused on expanding my technical expertise in cutting edge optical approaches to
uncover the mechanisms underlying perceptual learning in the tree shrew. Preliminary data suggest that a
transient and feature specific decrease in the inhibitory network response precedes changes in the excitatory
neuronal population associated with enhanced performance, showing that the learning process in tree shrew V1
layer 2/3 is a precise one where circuit elements are engaged with both feature and temporal specificity. I will
employ chronic 2-photon imaging in combination with novel genetic enhancers and precise RNAscope
technology to determine changes in the response properties of V1 inhibitory neural subpopulations during
perceptual learning (Aim 1). Additionally, I will define changes in the functional synaptic architecture of excitatory
neurons that undergo learning-related changes (Aim 2) by applying calcium imaging of dendritic spines through
the learning process. Finally, I will establish the spatiotemporal recruitment of acetylcholine release during
discrimination learning (Aim 3) by taking advantage of a recently developed cholinergic sensor that can be
imaged chronically through learning stages. This project capitalizes on the functional organization of the tree
shrew V1 area as a unique model to address how perceptual learning is implemented in highly structured cortical
networks akin to those found in the primate cortex. The studies will take place in a collaborative environment at
Max Planck Florida Institute for Neuroscience (MPFI) known for developing innovative approaches to address
fundamental questions about neural circuits and hosting one of the few tree shrew colonies in the world.
Completion of these aims and training plan will lead to a comprehensive framework describing the progression
of learning-related plasticity in a functionally structured cortex upon which I will build an independent research
program in the future.
项目摘要
在发育过程中,经验以一种显著的方式塑造了皮质感觉表征,但在发育之后
塑性的成熟能力变得有限。受严格控制的成熟皮质的可塑性使
学习,但会阻碍大脑在受伤、中风或感觉延长后恢复适当功能的能力
损失。研究成人阶段知觉学习的基础机制将促进我们的理解
并将为开发促进成人可塑性的新方法提供基础
大脑。树鼠(Tupaia Belangeri)的最新研究,这种高度视觉的哺乳动物分享大脑皮层
灵长类动物的组织特征表明,学习基于奖励的定向辨别任务会导致
兴奋性反应的长期变化提高了任务相关刺激之间的区分性
成熟初级视皮层(V1)。然而,我们对潜在的电路机制缺乏清楚的了解
对这些变化负有责任。我将结合我以前研究突触机制的经验
新的培训侧重于扩展我在尖端光学方法方面的技术专长,以
揭示树精知觉学习的潜在机制。初步数据显示,
在兴奋性改变之前,抑制性网络反应的暂时性和特异性下降
神经元群与增强的表现相关,表明树鼠V1的学习过程
第2/3层是一个精确的层,其中电路元件同时具有特性和时间特性。这就做
将慢性双光子成像与新型基因增强剂和精密RNAScope相结合
检测V1抑制神经亚群反应特性变化的技术
知觉学习(目标1)。此外,我还将定义兴奋性神经元功能性突触结构的变化。
经历学习相关变化的神经元(目标2)--通过应用树突棘的钙成像
学习过程。最后,我将建立乙酰胆碱释放的时空招募
通过利用最近开发的胆碱能传感器的优势进行辨别学习(目标3)
通过学习阶段慢性成像。这个项目充分利用了树的功能组织
Shrew V1区域作为一个独特的模型来解决如何在高度结构化的大脑皮层中实施知觉学习
网络与灵长类皮质中发现的网络相似。研究将在以下地点的协作环境中进行
马克斯·普朗克佛罗里达神经科学研究所(MPFI)以开发创新的方法来解决
关于神经回路的基本问题,以及世界上为数不多的树鼠栖息地之一。
完成这些目标和培训计划将产生一个描述进展的全面框架
我将在此基础上进行一项独立的研究
未来的计划。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Gabriela del Mar Rodriguez其他文献
Gabriela del Mar Rodriguez的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Gabriela del Mar Rodriguez', 18)}}的其他基金
Circuit dynamics underlying perceptual learning in the functionally organized visual cortex
功能组织的视觉皮层感知学习的回路动力学
- 批准号:
10599145 - 财政年份:2022
- 资助金额:
$ 6.98万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 6.98万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 6.98万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 6.98万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 6.98万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 6.98万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 6.98万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 6.98万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 6.98万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 6.98万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 6.98万 - 项目类别:
Research Grant