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Developing A Transition MicroElelectrode Array for Large-scale Brain Recording

开发用于大规模脑记录的过渡微电子电极阵列

基本信息

批准号：
10463817
负责人：
Yantao Fan
金额：
$ 22.66万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10463817
关键词：
3D Print Address Agar Aging Axon Behavior Biocompatible Materials Biodegradation Biological Biology Biomedical Engineering Biopolymers Brain Brain Mapping Brain region Cells Custom Data Development Devices Dimensions Electrodes Emotions Encapsulated Environment Failure Future Gel Goals Human Hybrids Image Immune response Implanted Electrodes In Vitro Incubators Industry Inflammatory Literature Measurement Medical Memory Methodology Microelectrodes Microfabrication Morphology Neurons Neurosciences Outcome Oxides Patients Performance Periodicity Phosphate Buffer Physiological Polymers Process Property Rattus Repeat Surgery Research Resolution Saline Signal Transduction Silicon Spectrum Analysis Stains Synapses System Technology Testing Time Tissues Utah Work base biocompatible polymer biodegradable polymer biomaterial compatibility brain computer interface brain machine interface complex biological systems density design electric impedance experimental study fluorescence imaging implantation in vitro testing in vivo innovative technologies insight mechanical properties nerve stem cell nervous system disorder neural circuit polymerization prevent prototype relating to nervous system spatiotemporal stem cells tissue phantom two-photon voltage

项目摘要

Project Summary The brain’s functions are determined by its neural circuits, which consist of approximately 85 billion neuronal cells. Current brain recording technology is not sufficient to accomplish the goal of a high resolution mapping of brain activity due to the lack of a large-scale recording technology. Another vital challenge for current brain recording technology is obtaining longer lifetime for the implanted electrodes to prevent repeated surgeries. As over time, the harsh physiological environment (wet, ionic, reactive oxidizing species, immune response, etc.) in the neural tissue breaks down and/or encapsulates the electrode implants. To overcome these obstacles, we propose to develop and validate an implantable Transition Micro- Electrode Array (tMEA) for large-scale brain recording and modulation. This approach has the potential to eventually achieve an interface density of 106 “electrodes” per cm2, which is several orders of magnitude beyond established neural recording solutions. Except for the ultra-high recording capability, radically different from existing neural technologies, the tMEA uses living neurons as means of electrical recording and its axon guiding probes will be fabricated from degradable biopolymer via 3D printing. We expect the biocompatibility of the tMEA’s unique design will greatly decrease tissue damage and may suppress inflammatory immune response in the brain. The tMEA technology will use biopolymers that degrade safely after implantation, exposing living neural stem cells that will project their axons into local brain regions to form synaptic connections with the patient’s own neurons. In this way, the biological neuronal axons grow into a stable “electrode array” and replace a failure-prone abiotic interface with natural biotic connections act as a high- performance brain-machine interface. All these distinctive features endow the tMEA with unique potential for neuroscientists and clinicians to explore human brain functions and treat neurological disease, enabling an advancement of neuroscience, medical practice, and a variety of other future technologies.

项目总结