Ion Channels in Context: Structure and function in native cells and macromolecular complexes

摘要 这项提案请求资金支持普通生理学家学会第75届年度研讨会 (SGP)，题为《上下文中的离子通道：天然细胞和大分子中的结构和功能》 复合体。“会议将于2022年9月7日至11日在北京海洋生物实验室举行。 马萨诸塞州伍兹霍尔SGP研讨会作为生理学家的领先会议享有盛誉， 所有职业阶段和专业领域的细胞生物学家和生物物理学家。每年的会议主题 是独一无二的。通过这种方式，SGP研讨会突出了及时和新兴的主题，同时利用了经过验证的后勤 结构，出色的行政支持，以及潜在与会者的既定基础。 2022年会议将汇集约175名科学家和学员，讨论小说和 关于天然细胞中离子通道功能的基础研究。会议的规模， 而MBL的场地允许在一个环境中展示各种研究主题 最大限度地促进不同职业水平的调查人员之间的互动，促进个人讨论。这个 2022年会议的总体目标是强调将促进在以下方面取得进展的新兴概念和工具 了解离子通道如何在细胞环境中发挥作用。库尔特·比姆(美国国家科学院， 科罗拉多大学)将发表SGP“生理学之友”的主旨演讲。他的工作是在 骨骼肌的兴奋-收缩偶联体现了离子通道工作在 大分子复合体完成一个协调的和基本的生理过程。这次会议 组织者和合作个人，凯瑟琳·普罗恩扎博士(科罗拉多大学)和马修·特鲁多博士(科罗拉多大学 马里兰州)是离子通道功能和调节领域的专家。他们聚集了一支热情的 一组特邀演讲者，研究不同生理系统中广泛的离子通道。被邀请者 发言者反映了组织者和SGP对促进多样性和平等的承诺：49%的人是 妇女和24%的人是代表不足的少数族裔。受邀的演讲者还包括所有职业领域的调查人员 分期(早期22%，中期24%，老年54%)。会议上的会议将涵盖本地小区中的信道功能， 通道调节和变构，以及疾病状态下的通道功能。会议的一个重要目标是 促进发展，为学员提供机会。为此，日程表包括3张海报 会议，从提交的摘要中挑选出24个简短的演讲，以及2个职业发展研讨会。具体的 研讨会的目的是(1)讨论与离子通道功能有关的前沿进展 生理背景；(2)促进新的和跨学科的对话和合作；以及(3) 提拔职业生涯初期的调查人员，增强多样性。

ABSTRACT This proposal requests funds to support the 75th Annual Symposium of the Society of General Physiologists (SGP), entitled “Ion Channels in Context: Structure and Function in Native Cells and Macromolecular Complexes.” The meeting will be held on September 7-11, 2022 at the Marine Biological Laboratory (MBL) in Woods Hole, MA. The SGP symposium has an established reputation as the leading meeting for physiologists, cell biologists, and biophysicists across all career stages and professional arenas. Each year the meeting topic is unique. In this way, SGP Symposiums highlight timely and emerging topics while leveraging a proven logistical structure, excellent administrative support, and an established base of potential attendees. The 2022 conference will bring together approximately 175 scientists and trainees to discuss novel and fundamental research pertaining to ion channel function in the context of native cells. The size of the meeting, and the venue at the MBL allow presentation of a diverse range of research topics within an environment that maximizes interactions between investigators of different career levels and promotes individual discussions. The overarching goal of the 2022 meeting is to highlight emerging concepts and tools that will promote advances in understanding of how ion channels function in cellular environments. Kurt Beam (National Academy of Sciences, University of Colorado) will deliver the endowed SGP “Friends of Physiology” keynote address. His work on excitation-contraction coupling in skeletal muscle embodies the concept of ion channels working within a macromolecular complex to accomplish a coordinated and fundamental physiological process. The meeting organizers and co-PIs, Drs. Catherine Proenza (University of Colorado) and Matthew Trudeau (University of Maryland) are experts in the field of ion channel function and regulation. They have assembled an enthusiastic group of invited speakers who study a wide range of ion channels in different physiological systems. The invited speakers reflect the commitment of the organizers and the SGP to promoting diversity and equality: 49% are women and 24% are under-represented minorities. Invited speakers also include investigators at all career stages (early 22%, mid 24%, senior 54%). Sessions at the meeting will cover channel function in native cells, channel regulation and allostery, and channel function in disease states. An important goal of the meeting is to foster development and provide opportunities for trainees. To these ends, the schedule includes 3 poster sessions, 24 short talks selected from submitted abstracts, and 2 career development workshops. The specific aims of the symposium are (1) To discuss cutting-edge advances pertaining to ion channel function in physiological contexts; (2) To foster new and interdisciplinary conversations and collaborations; and (3) To Promote early-career investigators and enhance diversity.