Ion Channels in Context: Structure and function in native cells and macromolecular complexes

上下文中的离子通道：天然细胞和大分子复合物的结构和功能

• 批准号: 10467403
• 负责人: CATHERINE PROENZA
• 金额: $ 3万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10467403
• 关键词: Address; Allosteric Regulation; Animals; Atmosphere; Basic Science; Biological; Biophysics; Brain; Cardiovascular Diseases; Career Mobility; Cells; Clinical; Collaborations; Colorado; Communities; Complex; Coupling; Development; Diabetes Mellitus; Disabled Persons; Discipline; Disease; Drug Targeting; Educational workshop; Elements; Environment; Ethnic group; Exposure to; Faculty; Fostering; Friends; Funding; Goals; Heart; Individual; International; Ion Channel; Knowledge; Laboratories; Ligands; Lipids; Logistics; Macromolecular Complexes; Malignant Neoplasms; Maryland; Mentors; Methodology; Molecular; Muscle; Physiological; Physiological Processes; Physiology; Postdoctoral Fellow; Process; Proteins; Race; Regulation; Request for Proposals; Research; Research Personnel; Retina; Role; Schedule; Scientist; Skeletal Muscle; Societies; Structure; Students; System; Time; Translations; Underrepresented Minority; United States National Academy of Sciences; Universities; Woman; Wood material; Work; base; biological systems; body system; career; career development; distinguished professor; diversity and inclusion; fundamental research; innovation; medical schools; meetings; member; nervous system disorder; novel; novel therapeutics; organizational structure; posters; preclinical study; programs; symposium; tool; training opportunity

ABSTRACT This proposal requests funds to support the 75th Annual Symposium of the Society of General Physiologists (SGP), entitled “Ion Channels in Context: Structure and Function in Native Cells and Macromolecular Complexes.” The meeting will be held on September 7-11, 2022 at the Marine Biological Laboratory (MBL) in Woods Hole, MA. The SGP symposium has an established reputation as the leading meeting for physiologists, cell biologists, and biophysicists across all career stages and professional arenas. Each year the meeting topic is unique. In this way, SGP Symposiums highlight timely and emerging topics while leveraging a proven logistical structure, excellent administrative support, and an established base of potential attendees. The 2022 conference will bring together approximately 175 scientists and trainees to discuss novel and fundamental research pertaining to ion channel function in the context of native cells. The size of the meeting, and the venue at the MBL allow presentation of a diverse range of research topics within an environment that maximizes interactions between investigators of different career levels and promotes individual discussions. The overarching goal of the 2022 meeting is to highlight emerging concepts and tools that will promote advances in understanding of how ion channels function in cellular environments. Kurt Beam (National Academy of Sciences, University of Colorado) will deliver the endowed SGP “Friends of Physiology” keynote address. His work on excitation-contraction coupling in skeletal muscle embodies the concept of ion channels working within a macromolecular complex to accomplish a coordinated and fundamental physiological process. The meeting organizers and co-PIs, Drs. Catherine Proenza (University of Colorado) and Matthew Trudeau (University of Maryland) are experts in the field of ion channel function and regulation. They have assembled an enthusiastic group of invited speakers who study a wide range of ion channels in different physiological systems. The invited speakers reflect the commitment of the organizers and the SGP to promoting diversity and equality: 49% are women and 24% are under-represented minorities. Invited speakers also include investigators at all career stages (early 22%, mid 24%, senior 54%). Sessions at the meeting will cover channel function in native cells, channel regulation and allostery, and channel function in disease states. An important goal of the meeting is to foster development and provide opportunities for trainees. To these ends, the schedule includes 3 poster sessions, 24 short talks selected from submitted abstracts, and 2 career development workshops. The specific aims of the symposium are (1) To discuss cutting-edge advances pertaining to ion channel function in physiological contexts; (2) To foster new and interdisciplinary conversations and collaborations; and (3) To Promote early-career investigators and enhance diversity.

抽象的 该提案请求资金支持普通生理学家学会第 75 届年度研讨会 （SGP），题为“上下文中的离子通道：天然细胞和大分子中的结构和功能” 复合体。”会议将于2022年9月7-11日在中国海洋生物实验室（MBL）举行 马萨诸塞州伍兹霍尔。 SGP 研讨会作为生理学家的领先会议享有盛誉， 各个职业阶段和专业领域的细胞生物学家和生物物理学家。每年的会议主题 是独一无二的。通过这种方式，SGP 研讨会突出及时和新兴的主题，同时利用经过验证的后勤保障 结构、出色的行政支持以及已建立的潜在参与者基础。 2022 年的会议将汇集约 175 名科学家和学员，讨论新颖和 有关天然细胞中离子通道功能的基础研究。会议规模、 MBL 的场地允许在这样的环境中展示各种研究主题 最大限度地提高不同职业级别的调查人员之间的互动并促进个人讨论。这 2022 年会议的总体目标是突出新兴概念和工具，以促进技术进步 了解离子通道在细胞环境中如何发挥作用。库尔特·比姆（美国国家科学院院士， 科罗拉多大学）将发表 SGP 捐赠的“生理学之友”主题演讲。他的工作是 骨骼肌中的兴奋-收缩耦合体现了离子通道在内部工作的概念 完成协调和基本生理过程的大分子复合物。会议 组织者和共同PI，博士。凯瑟琳·普罗恩扎（科罗拉多大学）和马修·特鲁多（科罗拉多大学） 马里兰州）是离子通道功能和调节领域的专家。他们聚集了一支热情的 一群受邀演讲者研究不同生理系统中的各种离子通道。受邀的 发言者反映了组织者和 SGP 对促进多样性和平等的承诺：49% 女性，24% 是代表性不足的少数族裔。受邀演讲者还包括所有职业的调查员 阶段（早期 22%，中期 24%，高级 54%）。会议的会议将涵盖本机细胞中的通道功能， 通道调节和变构，以及疾病状态下的通道功能。此次会议的一个重要目标是 促进发展并为学员提供机会。为此，日程表包括 3 张海报 会议、从提交的摘要中选出的 24 场简短演讲以及 2 场职业发展研讨会。具体的 研讨会的目的是（1）讨论有关离子通道功能的前沿进展 生理背景； (2) 促进新的跨学科对话与合作； (3) 至 促进早期职业调查人员的发展并增强多样性。