Development of selective amyloid-responsive fluorescent probes
Development of selective amyloid-responsive fluorescent probes
批准号:
10467922
负责人:
Jerry Yang
金额:
$193.43万
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
未结题
起止时间:
2022-06-01 至 2025-05-31
关键词:
AddressAlzheimer&aposs DiseaseAlzheimer&aposs disease diagnosisAlzheimer&aposs disease patientAmyloidAmyloid beta-ProteinAmyloid depositionAmyloidosisAntineutrophil Cytoplasmic AntibodiesAttentionBindingBiological ProductsBrainCadaverCerebrospinal FluidCharacteristicsChargeChemicalsClinicalClinical TrialsComplexDataDementiaDepositionDetectionDevelopmentDiagnosisDiagnosticDiseaseDockingEarly DiagnosisEventExhibitsEyeFamilyFluorescenceFluorescent ProbesFrontotemporal DementiaGoalsHumanImageMeasurementMethodsMonitorNerve DegenerationNeurodegenerative DisordersOptical MethodsOpticsParkinson DiseasePatientsPhase III Clinical TrialsPositron-Emission TomographyPropertyProteinsReportingResearchRetinaSamplingSensitivity and SpecificityShapesSymptomsSystemic diseaseTauopathiesTechniquesTechnologyTestingTissuesTranslatingWorkalpha synucleinamyloid formationbasebrain tissuecostdesigndiagnostic tooldipole momentdisease diagnosisdisorder riskfluorescence imagingfluorophorein silicointerestlensmisfolded proteinmouse modelnanoporeneuropathologynovelpre-clinicalprotein aggregationprotein distributionradioligandratiometricretinal imagingsensor technologysingle moleculesynucleinopathytau Proteinstool
中文摘要
项目总结
英文摘要
Project Summary
Amyloid accumulation in the brain is a universal feature of Alzheimer’s disease (AD) and many other related
dementias and precedes clinical symptoms by several years. Methods for antemortem detection of amyloid
species may, therefore, aid in diagnosing and monitoring neurodegeneration, providing critical information that
can be used to devise a proper plan for patient management. While a number of clinical tools for detecting
amyloid in the brain or cerebral spinal fluid have been developed to help diagnose AD, methods to differentiate
AD from non-AD neuropathology in living patients are limited. We have recently developed two new families of
fluorescent probes that can selectively detect aggregated forms of tau or alpha-synuclein, which could address an
unmet need by extending the available toolbox for aiding in detection of amyloid or amyloid-like aggregates
associated with non-AD diseases such as Frontotemporal Dementia (FTD), Parkinson’s disease (PD), and other
tauopathies and synucleinopathies. The proposed research seeks to uncover new and reliable design principles
for developing such selective amyloid-responsive probes and will seek to evaluate their utility for detection of
amyloid species in emerging platforms for antemortem diagnostics. The Specific Aims of this proposal are to:
1) Develop fluorescent probes that exhibit selective enhancement of fluorescence upon binding to aggregated
alpha-synuclein or tau versus ABeta in solution and in tissue; 2) Develop a method to characterize the distribution of
aggregates of amyloidogenic proteins in biofluids; and 3) Evaluate whether selective amyloid-responsive
fluorescent probes can be used to image specific amyloid deposits in the retina.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
DOI:
10.3389/fchem.2023.1343118
发表时间:
2023
期刊:
FRONTIERS IN CHEMISTRY
影响因子:
5.5
作者:
[Teppang, Kristine L., Zhao, Qilin, Yang, Jerry]
通讯作者:
Yang, Jerry
Development of promoters of dendritic spine formation
-
批准号:9159683
-
项目类别:
-
资助金额:$36.29万
-
财政年份:2016
-
负责人:Jerry Yang
-
依托单位:
Equipment Supplement to 'Development of promoters of dendritic spine formation'
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批准号:9513795
-
项目类别:
-
资助金额:$8.97万
-
财政年份:2016
-
负责人:Jerry Yang
-
依托单位:
MOLECULES BOUND TO AMYLOID FIBRILS
-
批准号:8169614
-
项目类别:
-
资助金额:$0.24万
-
财政年份:2010
-
负责人:Jerry Yang
-
依托单位:
MOLECULES BOUND TO AMYLOID FIBRILS
-
批准号:7957624
-
项目类别:
-
资助金额:$0.31万
-
财政年份:2009
-
负责人:Jerry Yang
-
依托单位:
MOLECULES BOUND TO AMYLOID FIBRILS
-
批准号:7722455
-
项目类别:
-
资助金额:$0.2万
-
财政年份:2008
-
负责人:Jerry Yang
-
依托单位: