Porous Inorganic Framework Thin Film as Drug-Eluting Stent Coating
多孔无机框架薄膜作为药物洗脱支架涂层
基本信息
- 批准号:10466877
- 负责人:
- 金额:$ 11.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-11 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAddressAdverse effectsBalloon AngioplastyBehaviorBinding SitesBlood VesselsBlood flowChemicalsClinicalCommunitiesComplexCoronary arteryDevelopmentDiffusionDipyridamoleDrug CarriersDrug Delivery SystemsDrug ImplantsDrug ModelingsDrug MonitoringEndotheliumEnvironmentFilmFutureGrowthHealthHeartHigh Pressure Liquid ChromatographyHybridsHypersensitivityIbuprofenImmersionImmunosuppressive AgentsImplantIn VitroIronKnowledgeLeflunomideLigandsMechanicsMetalsMethodsMicroscopicMinority-Serving InstitutionModificationMonitorMorphologyOxidesPaclitaxelPatientsPerformancePersonsPharmaceutical PreparationsPolymersPowder dose formPreparationProceduresPropertyReactionReportingResearchResearch ActivityRiskSolidSpectrum AnalysisStainless SteelStentsStructureStudentsSurfaceTechniquesTestingTherapeuticTherapeutic AgentsThinnessThrombosisTissuesToxic effectVascular Diseasesantiproliferative drugsbasebiocompatible polymerbiomaterial compatibilitycarboxylatechemical bindingchemical bondcovalent bondcrosslinkdesigndrug release kineticseducation researchhigh riskimplantationin vivoinsightmechanical propertiesnovel therapeuticsrestenosisscaffoldscreeningstent thrombosistime use
项目摘要
Project Summary/Abstract
The primary objective of the proposed project is to prepare surface supportive porous inorganic
framework thin films that have superior properties for drug delivery. The second objective, which
helps with the realization of the first one, is to identify and better understand the chemical and
structural features that have the greatest impact on the drug loading and releasing conditions. To
accomplish these objectives, the PI proposes to modify and identify suitable surface platforms
(with specific chemical features) that can be used to attach selective iron-containing metal organic
framework (Fe-MOF) thin films. These biodegradable Fe-MOFs are composed of Fe(III) clusters
and various organic ligands as struts forming three-dimensional porous structures. The organic
nodes can also serve as binding sites to crosslink with functionalized metal substrates. The drug
loading/releasing with surface-supportive Fe-MOF thin films will be examined by spectroscopic
and microscopic methods. We will also evaluate the toxicity and mechanical durability of these Fe-
MOF coatings. The performance of these iron-containing inorganic frameworks as drug carriers
will be studied in vitro using surface techniques. The knowledge acquired from these initial studies
will be beneficial for the future in vivo studies of applying these Fe-MOF thin films as potential
drug-eluting stent coatings. In addition, the project aims to enhance the scientific understanding of
surface and interface interactions between porous hybrid materials and assorted therapeutic
agents. These results will lead to new insights and guide the material design for future drug-
eluting stents. The proposed research activities will provide excellent health-related research-
education opportunities for students in a minority serving institution like ours, which will bring a
significant positive impact to our community.
项目总结/文摘
项目成果
期刊论文数量(0)
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{{ truncateString('Fangyuan Tian', 18)}}的其他基金
Porous Inorganic Framework Thin Film as Drug-Eluting Stent Coating
多孔无机框架薄膜作为药物洗脱支架涂层
- 批准号:
10261349 - 财政年份:2020
- 资助金额:
$ 11.06万 - 项目类别:
Porous Inorganic Framework Thin Film as Drug-Eluting Stent Coating
多孔无机框架薄膜作为药物洗脱支架涂层
- 批准号:
10701711 - 财政年份:2020
- 资助金额:
$ 11.06万 - 项目类别:
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