Porous Inorganic Framework Thin Film as Drug-Eluting Stent Coating

多孔无机框架薄膜作为药物洗脱支架涂层

基本信息

  • 批准号:
    10466877
  • 负责人:
  • 金额:
    $ 11.06万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-11 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

Project Summary/Abstract The primary objective of the proposed project is to prepare surface supportive porous inorganic framework thin films that have superior properties for drug delivery. The second objective, which helps with the realization of the first one, is to identify and better understand the chemical and structural features that have the greatest impact on the drug loading and releasing conditions. To accomplish these objectives, the PI proposes to modify and identify suitable surface platforms (with specific chemical features) that can be used to attach selective iron-containing metal organic framework (Fe-MOF) thin films. These biodegradable Fe-MOFs are composed of Fe(III) clusters and various organic ligands as struts forming three-dimensional porous structures. The organic nodes can also serve as binding sites to crosslink with functionalized metal substrates. The drug loading/releasing with surface-supportive Fe-MOF thin films will be examined by spectroscopic and microscopic methods. We will also evaluate the toxicity and mechanical durability of these Fe- MOF coatings. The performance of these iron-containing inorganic frameworks as drug carriers will be studied in vitro using surface techniques. The knowledge acquired from these initial studies will be beneficial for the future in vivo studies of applying these Fe-MOF thin films as potential drug-eluting stent coatings. In addition, the project aims to enhance the scientific understanding of surface and interface interactions between porous hybrid materials and assorted therapeutic agents. These results will lead to new insights and guide the material design for future drug- eluting stents. The proposed research activities will provide excellent health-related research- education opportunities for students in a minority serving institution like ours, which will bring a significant positive impact to our community.
项目摘要/摘要 该项目的主要目标是制备表面支撑性的多孔无机材料。 具有优异的药物输送性能的骨架薄膜。第二个目标,即 有助于实现第一个,是识别和更好地理解化学和 对药物装载和释放条件影响最大的结构特征。至 为了实现这些目标,PI建议修改和确定合适的水面平台 (具有特定的化学特征)可用于选择性地附着有机含铁金属 骨架(Fe-MOF)薄膜。这些可生物降解的Fe-MOF由Fe(III)簇合物组成 以及各种有机配体作为支撑物形成三维多孔结构。有机食品 节点也可以作为与功能化金属底物交联物的结合部位。这种药 表面支撑型Fe-MOF薄膜的加载/释放将通过光谱进行检查 以及显微方法。我们还将评估这些铁的毒性和机械耐久性。 MOF涂料。这些含铁无机骨架作为药物载体的性能 将使用表面技术在体外进行研究。从这些初步研究中获得的知识 为今后这些Fe-MOF薄膜的体内潜在应用研究提供了有益的参考 药物洗脱支架涂层。此外,该项目还旨在增进对 多孔性杂化材料与多种治疗材料的表面和界面相互作用 探员们。这些结果将带来新的见解,并指导未来药物的材料设计- 洗脱支架。拟议的研究活动将提供与健康相关的优秀研究- 为像我们这样的少数族裔服务机构的学生提供教育机会,这将带来 对我们的社会产生了重大的积极影响。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Fangyuan Tian其他文献

Fangyuan Tian的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Fangyuan Tian', 18)}}的其他基金

Porous Inorganic Framework Thin Film as Drug-Eluting Stent Coating
多孔无机框架薄膜作为药物洗脱支架涂层
  • 批准号:
    10261349
  • 财政年份:
    2020
  • 资助金额:
    $ 11.06万
  • 项目类别:
Porous Inorganic Framework Thin Film as Drug-Eluting Stent Coating
多孔无机框架薄膜作为药物洗脱支架涂层
  • 批准号:
    10701711
  • 财政年份:
    2020
  • 资助金额:
    $ 11.06万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 11.06万
  • 项目类别:
    Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 11.06万
  • 项目类别:
    Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 11.06万
  • 项目类别:
    Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 11.06万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 11.06万
  • 项目类别:
    Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 11.06万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 11.06万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 11.06万
  • 项目类别:
    EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 11.06万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 11.06万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了