Pediatric musculOskeletal & RheumaTology Innovation COre center (PORTICO)

小儿肌肉骨骼

• 批准号: 10466931
• 负责人: Hermine I Brunner
• 金额: $ 67.88万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-16 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10466931
• 关键词: Address; Adolescent; Adult; Assessment tool; Biological Markers; Biometry; Caring; Child; Childhood; Chronic; Chronic Childhood Arthritis; Clinical Research; Communities; Data; Data Analytics; Data Display; Data Science; Decision Making; Development; Diagnostic; Diagnostic tests; Disease; Environment; Epidemiology; Family; Feasibility Studies; Fibromyalgia; Fostering; Goals; Health; Health Benefit; Image; Informatics; Interdisciplinary Study; Intervention; Investigation; Knowledge; Laboratories; Leadership; Lupus; Magnetic Resonance Imaging; Measurement; Measures; Medical; Medical center; Medicine; Methodology; Methods; Mission; Musculoskeletal; Musculoskeletal Diseases; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Nature; Outcome; Pain; Patient Outcomes Assessments; Patients; Pediatric Hospitals; Phenotype; Pilot Projects; Population; Reporting; Research; Research Design; Research Infrastructure; Research Personnel; Research Support; Research Training; Resources; Rheumatism; Rheumatology; Science; Services; Statistical Data Interpretation; System; Technology; Testing; Therapeutic; Translational Research; Ultrasonography; United States National Institutes of Health; base; biomechanical test; career; clinical care; clinical center; clinical decision-making; curative treatments; dashboard; data acquisition; data pipeline; disability; disorder control; empowered; evidence base; health related quality of life; imaging modality; improved; innovation; insight; novel; novel marker; outreach program; patient safety; pediatric rheumatic diseases; personalized approach; point of care; precision medicine; programs; protocol development; ranpirnase; research data dissemination; research study; response; shared decision making; societal costs; synergism; tool

ABSTRACT/PROJECT SUMMARY - OVERALL COMPONENT Children with pediatric rheumatic and non-inflammatory musculoskeletal diseases (PMSKD) have an urgent need for evidence-based medical care that considers the striking differences between pediatric and adult populations. To address these gaps in scientific knowledge, we propose to establish a Pediatric musculOskeletal & RheumaTology Innovation COre center (PORTICO) at the Cincinnati Children' Hospital Medical Center. Objectives of PORTICO will be to promote impactful research in PMSKD, locally and nationally, with a focus on our well-established research programs in juvenile arthritis, lupus and juvenile fibromyalgia. Specific Aims are: Aim 1: To promote innovation and support clinical research with advanced data science, data analytics capabilities, and data pipeline development. Aim 2: To invigorate cross-disciplinary team science of the local but also national community of researchers in PMSKD. Aim 3: To enhance research in PMSKD by developing and offering cutting-edge assessment tools for capturing the benefits of health interventions and delineating PMSKD phenotypes. Advanced imaging services to support PMSKD research (ultrasonography, magnetic resonance imaging, biomechanical assessment) will be provided, new imaging-based methods and scoring systems developed and an interactive dashboards to synthesize information from patient reported assessments, imaging data, novel biomarkers and traditional disease measures developed in support of improved shared medical decision making. Expected result: PORTICO will create a vibrant research environment that fosters productive team science to find answers to important scientific unknowns regarding PMKSD. Innovation will be sought by (1) developing diagnostics for PMSKD (laboratory tests, imaging tests) and testing their integration into clinical care, and (2) advancing evidence-based based therapies, with focus on JIA, cSLE and JFM. Spread of PORTICO findings and increase of the local & national Research Community will be achieved by multisite research studies, PORTICO's Outreach Program, and its Pilot & Feasibility Studies Program. Alignment with the efforts of other CCCRs, other organizations involved in PMSKD research, and the local research environment is anticipated to potentiate spread of ideas and innovation by PORTICO investigators

摘要/项目总结-整体组件 患有小儿风湿性和非炎症性肌肉骨骼疾病（PMSKD）的儿童迫切需要 需要基于证据的医疗护理，考虑到儿童和成人之间的显着差异 人口。为了解决这些科学知识的差距，我们建议建立一个儿科肌肉骨骼 和风湿病创新核心中心（PORTICO）在辛辛那提儿童医院医疗中心。 PORTICO的目标将是促进PMSKD在地方和国家的有影响力的研究，重点是 我们在青少年关节炎，狼疮和青少年纤维肌痛方面的完善研究计划。具体目标是： 目标1：通过先进的数据科学和数据分析促进创新并支持临床研究 能力和数据管道开发。 目标2：振兴地方和国家研究人员社区的跨学科团队科学， PMSKD。 目标3：通过开发和提供先进的评估工具， 健康干预的益处和描述PMSKD表型。高级成像服务，支持 PMSKD研究（超声检查、磁共振成像、生物力学评估）将在 提供了新的基于成像的方法和评分系统，以及交互式仪表板， 综合来自患者报告的评估、成像数据、新型生物标志物和传统生物标志物的信息， 制定疾病措施以支持改善共享医疗决策。 预期成果：PORTICO将创造一个充满活力的研究环境，促进富有成效的团队科学， 找到关于PMKSD的重要科学未知的答案。创新将通过（1）开发 PMSKD诊断（实验室检查，影像学检查），并测试其与临床护理的整合，以及（2） 推进循证治疗，重点关注JIA、cSLE和JFM。PORTICO调查结果的传播 地方和国家研究社区的增加将通过多地点研究来实现， PORTICO的推广计划及其试点和可行性研究计划。与其他组织的努力保持一致 CCCR、参与PMSKD研究的其他组织和当地研究环境预计将 加强PORTICO研究人员的思想和创新传播