Administrative Supplement to CWRU Center for Multimodal Evaluation of Engineered Cartilage
Administrative Supplement to CWRU Center for Multimodal Evaluation of Engineered Cartilage
批准号:
10468459
负责人:
Arnold Irwin Caplan
金额:
$31.23万
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-09-15 至 2022-08-31
关键词:
Administrative SupplementAdoptionAnimal TestingAppearanceAutomationBiological ProductsBioreactorsCartilageCellsCessation of lifeClinicalClustered Regularly Interspaced Short Palindromic RepeatsCollaborationsCommunitiesCongenital AbnormalityData Management ResourcesDiseaseDrug ScreeningEngineeringEvaluationFeedbackFundingGenerationsGoalsInstitutesKnowledgeLaboratoriesMeasuresMedicalMethodsMolecularOxygenPatientsPharmacologic SubstancePhenotypeProtocols documentationReporterResourcesStructureTechnologyTestingTimeTissue EngineeringTissuesTraumabasecost effectivedesignmultimodalitynew technologynon-invasive monitorpersonalized medicinepreventprototyperegenerativeresearch and developmentscaffoldsensortechnology research and developmentuptake
中文摘要
尽管几十年来取得了重大进展,但组织工程医疗产品(TEMPs)却很少
英文摘要
Despite significant advances over several decades, very few Tissue Engineered Medical Products (TEMPs) have
been clinically or commercially successful, as a significant technology gap, known as the “Valley of Death”, has
prevented their scalable, consistent and cost-effective manufacture. This proposal is for bridge funding pending
the competing renewal of the current “Case Center for Multimodal Evaluation of Engineered Cartilage”. There is
a growing need for TEMPs in multiple applications. We therefore believe that now is the time for a bold shift from
our original focus on cartilage-centric evaluation technologies to developing, demonstrating, and deploying novel
technologies to enable Quality-by-Design manufacturing of a variety of structural tissues, and to, thus, bridge
the aforementioned Valley of Death. The goal of the Center is the adoption of our technologies by the TEMP
community at large. Consequently, the Center, will be renamed “Center for Modular Manufacturing of Structural
Tissues” (CM2OST), and will apply knowledge and technology developed during the first 5 years to manufactur-
ing-oriented challenges. The Center will be a consortium between CWRU and the Advanced Regenerative Man-
ufacturing Institute (ARMI), and will focus on technologies that enable scalable, modular, automated, closed
(SMAC) manufacturing. The Specific Aims of this Administrative Supplement proposal are to complete a subset
of the tasks proposed in the Technology Research and Development (TR&D) components of the A0 submission,
specifically, Aim 1 will pursue the TR&D-1 goals to generation genetically encoded cell sensors for dynamic
sensing of cellular phenotype and function, and to develop molecular sensors for dynamic non-invasive monitor-
ing of cell phenotype and function using CRISPR-Cas13 based reporters. Aim 2 will pursue the TR&D-2 of adapt-
ing oxygen and lactate optodes into scaffolds to measure local metabolite levels and cellular oxygen uptake
rates. Aim 3 will pursue TR&D-3 task towards developing bioreactors with integrated sensors for feedback con-
trol, and will physically integrate them with the Tissue Foundry, an ARMI prototype automated TEMP assembly
line. Aim 4 will be to demonstrate integration of O2 and OUR sensors with the automation and data management
system of the Tissue Foundry. The requested funding will allow us to keep the Center operational as a national
resource for collaborations and as a platform for developing, testing, validating, and disseminating new technol-
ogy, methods, and protocols for TEMP manufacturing.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Role of Perivascular Mesenchymal Stem Cells (pMSCs) in the Bone Marrow Niche and the Extracellular Matrix in the Control of Skeletal Metastasis
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批准号:10413249
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项目类别:
-
资助金额:$40.85万
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财政年份:2020
-
负责人:Arnold Irwin Caplan
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依托单位:
Role of Perivascular Mesenchymal Stem Cells (pMSCs) in the Bone Marrow Niche and the Extracellular Matrix in the Control of Skeletal Metastasis
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批准号:10028072
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项目类别:
-
资助金额:$36.83万
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财政年份:2020
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负责人:Arnold Irwin Caplan
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依托单位:
Role of Perivascular Mesenchymal Stem Cells (pMSCs) in the Bone Marrow Niche and the Extracellular Matrix in the Control of Skeletal Metastasis
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批准号:10248515
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项目类别:
-
资助金额:$36.83万
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财政年份:2020
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负责人:Arnold Irwin Caplan
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依托单位:
Administrative Core
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批准号:10554849
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项目类别:
-
资助金额:$15.17万
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财政年份:2016
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负责人:Arnold Irwin Caplan
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依托单位:
CWRU Center for Multimodal Evaluation of Engineered Cartilage
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批准号:9072578
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项目类别:
-
资助金额:$128.43万
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财政年份:2016
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负责人:Arnold Irwin Caplan
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依托单位:
Center for Modular Manufacturing of Structural Tissues
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批准号:10554848
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项目类别:
-
资助金额:$106.37万
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财政年份:2016
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负责人:Arnold Irwin Caplan
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依托单位:
CWRU Center for Multimodal Evaluation of Engineered Cartilage
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批准号:9895783
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项目类别:
-
资助金额:$118.85万
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财政年份:2016
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负责人:Arnold Irwin Caplan
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依托单位:
CWRU Center for Multimodal Evaluation of Engineered Cartilage
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批准号:8890431
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项目类别:
-
资助金额:$41.93万
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财政年份:2014
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负责人:Arnold Irwin Caplan
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依托单位:
CWRU Center for Multimodal Evaluation of Engineered Cartilage
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批准号:8901167
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项目类别:
-
资助金额:$38.79万
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财政年份:2014
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负责人:Arnold Irwin Caplan
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依托单位:
COFUND NIBIB
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批准号:8380793
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项目类别:
-
资助金额:$19.03万
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财政年份:2012
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负责人:Arnold Irwin Caplan
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依托单位:
Bone Marrow MSCs/Pericytes: Gatekeepers Controlling Skeletal Metastasis.
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批准号:8690795
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项目类别:
-
资助金额:$31.6万
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财政年份:2012
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负责人:Arnold Irwin Caplan
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依托单位:
Bone Marrow MSCs/Pericytes: Gatekeepers Controlling Skeletal Metastasis.
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批准号:8535135
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项目类别:
-
资助金额:$30.62万
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财政年份:2012
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负责人:Arnold Irwin Caplan
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依托单位:
Biomimetic Tissue-engineered Articular Cartilage Repair
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批准号:8309226
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项目类别:
-
资助金额:$12.83万
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财政年份:2011
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负责人:Arnold Irwin Caplan
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依托单位:
COFUND NIBIB
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批准号:8309228
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项目类别:
-
资助金额:$19.03万
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财政年份:2011
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负责人:Arnold Irwin Caplan
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依托单位:
COFUND NIBIB
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批准号:8153678
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项目类别:
-
资助金额:$19.8万
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财政年份:2010
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负责人:Arnold Irwin Caplan
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依托单位:
Biomimetic Tissue-engineered Articular Cartilage Repair
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批准号:8118204
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项目类别:
-
资助金额:$13.39万
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财政年份:2010
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负责人:Arnold Irwin Caplan
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依托单位:
Biomimetic Tissue-engineered Articular Cartilage Repair
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批准号:7904817
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项目类别:
-
资助金额:$15.63万
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财政年份:2009
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负责人:Arnold Irwin Caplan
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依托单位:
Tissue Engineered Cartilage Repair
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批准号:7904823
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项目类别:
-
资助金额:$117.37万
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财政年份:2008
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负责人:Arnold Irwin Caplan
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依托单位:
Tissue Engineered Cartilage Repair: Molecular Imaging of Condrogenesis
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批准号:7773875
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项目类别:
-
资助金额:$15.7万
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财政年份:2008
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负责人:Arnold Irwin Caplan
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依托单位:
Tissue Engineered Cartilage Repair
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批准号:8118210
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项目类别:
-
资助金额:$112.81万
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财政年份:2008
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负责人:Arnold Irwin Caplan
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依托单位:
海外基金