REDS-IV-P DOMESTIC HUBS PHASE 2

受体流行病学和供体评估研究iv -儿科（red - iv - p）项目的目标是评估和提高血液供应的安全性和可用性，以及输血治疗的安全性和有效性，不仅关注成年人，还关注需要输血的新生儿和儿童。red - iv - p是美国和巴西的一个为期7年的多中心项目，负责对献血者和输血接受者进行流行病学和实验室研究。red - iv - p分为3个阶段：1)第一阶段（1-2年）包括制定red - iv - p研究方案，开发和试点关联捐赠成分-受体（静脉对静脉）数据库，开展第一阶段研究，并使用现有输血数据库进行数据分析；2)第二阶段（3-5年）包括第二阶段研究方案的实施，静脉到静脉数据库的编制和数据分析，以及通过演讲和出版物传播研究结果；3)第三阶段（6-7年级）包括通过演讲和出版物传播研究结果，关闭数据库，并向NHLBI提供所有可交付成果。国内计划由美国境内的4个研究站点组成，这些站点被称为国内中心，并由数据协调中心（DCC）和中央实验室提供支持。每个中心都有一个血液中心和输血服务，为参与red - iv - p的几家专科护理医院和社区医院（总共22家医院）提供服务。该合同是为其中一个国内枢纽的第二阶段的基期而签订的。

The goal of the Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric (REDS-IV-P) program is to evaluate and improve the safety and availability of the blood supply as well as the safety and effectiveness of transfusion therapies with attention to not only adults but also neonates and children who need transfusion. REDS-IV-P is a seven-year multicenter program in the US and in Brazil charged with conducting epidemiologic and laboratory studies in blood donors and transfusion recipients. REDS-IV-P is divided into 3 phases: 1) Phase 1 (Years 1-2) includes development of the REDS-IV-P research protocols, the development and pilot of a linked donation-component-recipient (vein to vein) database, the conduct of phase 1 research studies, and the conduct of data analyses using existing transfusion databases; 2) Phase 2 (Years 3-5) includes the conduct of phase 2 research protocols, compilation of the vein to vein database and data analyses, and dissemination of findings through presentations and publications; and 3) Phase 3 (Years 6-7) includes dissemination of findings through presentations and publications, closure of databases, and provision of all deliverables to NHLBI. The domestic program consists of 4 research sites within the United States which are referred to as Domestic Hubs and are supported by a data coordinating center (DCC) and a central laboratory. Each Hub has a blood center and transfusion services that serve several specialty care and community hospitals participating in REDS-IV-P (total of 22 hospitals). This contract is for the base period of phase 2 for one of the domestic hubs.