FASEB SRC: The 6th International Conference on Retinoids

项目摘要/摘要 这份NIH R13申请申请为2022年美国学会联合会申请部分资金 实验生物学“第六届国际维甲酸会议”将在俄亥俄大学举行， 俄亥俄州雅典，2022年6月5日至2022年6月10日。FASE B关于维甲酸的科学研究会议 自1982年以来每隔一年举行一次，计划于2022年举行的会议将是第21届FASEB Science 维甲酸研究会议。这个每两年举行一次的研究会议出席人数非常多(范围 在过去的40年里从100到200名与会者)，并且仍然是唯一的主要国家和国际 会议致力于维甲酸类化合物的研究，并全面解决广谱问题 以一种综合的方式进行类维A酸作用和应用。而作用机制和生物 维甲酸的功能已被深入研究，对其认识和应用的需求也越来越大 维甲酸在人类营养和疾病中的作用。目前，大量的研究活动得到了美国国立卫生研究院的支持 (NIH记者数据库表明，NIH资助的个人研究拨款涉及以下方面 类维A/维生素A生物学)。要讨论的主要主题包括维甲酸的基本和翻译方面。 生物学：3场关于维甲酸机制的会议(I，维甲酸受体，维甲酸受体介导的生物学；II，维甲酸 新陈代谢、动态平衡和酶学；III，发育、干细胞和再生生物学)；3节 关于维甲酸和疾病(一，免疫紊乱和免疫学；二，信号和代谢功能障碍；三， 癌症和相关病理学)，以及两次分子治疗会议(I，维甲酸机制和新 靶标；二、雷克索类化合物和新的药理应用)。总体目标是将一组 致力于研究的人员(资深科学家、职业生涯中期科学家、初级科学家、博士后研究员和 研究生)，他们在不同的学科工作(如生物化学家、分子生物学家、营养学家、 癌症研究人员、视觉研究人员、干细胞生物学家、生物物理学家、结构生物学家、免疫学家、 化学家和临床医生)介绍和讨论他们的最新研究成果，这些研究成果共同关注 维甲酸。为了鼓励新的/年轻的研究人员和受训人员参加这次会议，我们计划提供六个职业- 定向培训课程和六次专家见面会。提高早期调查人员的知名度 和实习生通过口头陈述，我们计划8次演讲机会和29次简短演讲和 胶囊报告将从提交的摘要中选择演示文稿。这次会议是一次强烈的 过去得到了美国国立卫生研究院的支持。我们诚挚地请求部分支持2022年FASEB维甲酸会议 为了增加代表不足的女科学家、实习生、博士后研究员和早期- 促进研究人员进入这一研究领域，以促进跨学科和翻译 科学以及基础科学家和临床医生之间的合作。

PROJECT SUMMARY / ABSTRACT This NIH R13 application requests requesting partial funding for the 2022 Federation of American Societies for Experimental Biology (FASEB) “6th International Conference on Retinoids” that will be held at Ohio University, Athens, OH from June 5, 2022 to June 10, 2022. The FASEB Science Research Conference on Retinoids has been held every other year since 1982 where the meeting planned for 2022 will be the 21st FASEB Science Research Conference on Retinoids. This biennial research conference has been very well attended (ranging from 100 to 200 attendees over the past 40 years) and remains the only major national and international conference committed to focus on the studies of retinoids, and to comprehensively address the broad spectrum of retinoid actions and application in an integrative manner. While the mechanisms of action and the biological functions of retinoids have been intensively studied, there is an increasing need for understanding and applying retinoids in human nutrition and diseases. Currently, a great deal of research activity is supported by the NIH (the NIH RePORTER database indicates 2190 NIH funded individual research grants involving aspects of retinoid/vitamin A biology). The main topics to be addressed include both basic and translational fronts of retinoid biology: 3 sessions on retinoid mechanisms (I, Retinoid receptors, retinoid receptor-mediated biology; II, Retinoid metabolism, homeostasis, and enzymology; III, Development, stem cell and regenerative biology); 3 sessions on retinoids and disease (I, Immune disorders and immunology; II, Signaling and metabolic dysfunction; III, Cancer and related pathologies), and 2 sessions on molecular therapeutics (I, Retinoid mechanisms and novel targets; II, Rexinoids and novel pharmacological applications). The overall goal is to bring together a group of committed investigators (senior scientists, mid-career scientists, junior scientists, postdoctoral fellows, and graduate students), who work in diverse disciplines (as biochemists, molecular biologists, nutritional scientists, cancer researchers, vision researchers, stem cell biologists, biophysicists, structural biologists, immunologists, chemists, and clinicians) to present and discuss their latest research findings that share a common focus on the retinoids. To encourage new/young investigators and trainees to attend this meeting, we plan to offer six career- oriented training sessions and six meet-the-expert sessions. To increase visibility of early-stage investigators and trainees through oral presentations, we plan eight speaking opportunities and twenty-nine short talk and capsule reports presentations to be chosen from the submitted abstracts. This meeting has been strongly supported by NIH in the past. We respectfully request partial support for the 2022 FASEB Retinoid Conference to increase the attendance by under-represented and women scientists, trainees, postdoctoral fellows, and early- stage investigators to facilitate entry into this research area in order to spur interdisciplinary and translational science as well as collaborations between basic scientists and clinicians.