Kappa-Flu

高致病性禽流感（HPAI）病毒在全球的出现以及随后对野生鸟类的适应导致野生鸟类和家禽的死亡率达到创纪录水平，并正在发展成为对欧洲野生动物、家禽和人类健康的地方性传染病威胁。高致病性禽流感病毒的持续进化正在扩大其地理分布和宿主范围。为了应对这一全球性问题，KAPPA FLU汇集了来自欧洲、北美和亚洲的顶级专家。KAPPA-FLU的总体目标是确定决定高致病性禽流感病毒在野生鸟类中维持和远距离传播的关键病毒、宿主相关因素和环境因素的特征，目标是提高基于风险的监测、预防和控制家禽和野生动物中高致病性禽流感的能力，及其对人类健康的潜在影响。KAPPA-FLU将遵循三个研究主题。主题A（疾病生态学）通过基于风险的监测策略和考虑气候变化的影响，深入了解迁徙水鸟和外溢宿主（包括常驻野生动物和家禽）中高致病性禽流感病毒的种群动态。主题B（病毒学）研究野生鸟类和家禽中高致病性病毒的演变及其对人类和其他哺乳动物造成的日益增加的风险。基于上述结果，主题C（农业生态系统风险）使用机器学习算法识别和建模预防和控制策略（包括疫苗接种）。来自社会不同部门的行为者将通过多行为者小组在将成果转化为政策和实践方面发挥关键作用。通过这种方式，KAPPA-FLU将逐步增进对高致病性禽流感种群动态和进化的了解，从而为可持续家禽生产系统和改善公共卫生作出贡献。

The global emergence of highly pathogenic avian influenza (HPAI) viruses and the subsequent adaptation to wild birds has resulted in record mortality of wild birds and poultry and is developing into an enzootic threat for wildlife, poultry and human health in Europe. The ongoing evolution of HPAI virusesis expanding their geographical distribution and host range. To deal with this global problem, KAPPA FLU brings together top experts from Europe, North America and Asia. The overall objective of KAPPA-FLU is the characterization of key viral, host-related and environmental factors that determine the maintenance and the long-distance spread of HPAI viruses in wild birds, with the goal of improving capacities for risk-based surveillance, prevention and control of HPAI in poultry and wildlife, and its potential impact on human health. KAPPA-FLU will follow three research themes. Theme A (Disease ecology) provides a deep understanding of the population dynamics of HPAI virusesin migratory waterbirds and spill-over hosts, both resident wildlife and poultry, through risk-based surveillance strategies, and accounting for the impact of climate change. Theme B (Virology) studies the evolution of HPAI viruses in wild birds and poultry and the resulting increasing risk to humans and other mammals. Based on the above results, theme C (Agro-ecosystem risk) identifies and models prevention and control strategies (including vaccination) using machine learning algorithms. Actors from different sectors of society will, through the Multi-Actor Panel, play key roles in translating results into policy and practice. In this way, KAPPA-FLU will make stepwise advances in knowledge of the population dynamics and evolution of HPAI, and thus contribute to a sustainable poultry production system and improved public health.