Demonstrating the potential for portable detection of bird flu.

展示便携式检测禽流感的潜力。

• 批准号: 10090901
• 金额: $ 26.62万
• 依托单位: B G RESEARCH LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10090901
• 关键词: Demonstrating; potential; portable; detection; bird

Project aim is to provide capability for early in-field direct testing of unprocessed biological samples e.g. swabs and blood for economically important veterinary pathogens, in this case screening swab samples taken from the beaks and cloaca of birds for detecting "bird flu". Initially we aim to support existing lab testing and ultimately explore the potential for moving tests into the field or farm.BG Research have developed a novel method and instrument for performing sensitive in-field molecular diagnostic tests for the detection of viruses without the requirement for expert scientists or shipping of samples to a test-lab and utilising the gold-standard PCR test methodology. Tests could be performed at ports of entry to prevent diseases being imported, on farms or at slaughterhouses to support surveillance/quarantine and emergency response.By performing rapid, sensitive, and cost-effective tests wherever required, the BGR technology could help protect the UK by preventing potential importation of infectious diseases at entry points and expedite outbreak response where incursions require rapid disease response activities. For example, the outbreaks of FMD in the UK cost the economy £10bn and COVID-19 is thought to have originated from wildlife. Such technology could assist Defra to more effectively monitor transboundary veterinary diseases and provide real-time data to contribute to the control of these diseases, reducing the socio-economic impacts of future outbreaks.We will develop the platform from a lab-based technology demonstrator into a late-stage prototype capable of being operated off-grid and moving the technology closer to the intended portable testing market. Test development assessment will be undertaken at the Animal and Plant Health Agency (APHA) where the necessary scientific expertise and facilities required to work with these pathogens are available. Bird flu has been in the news continually for the past few years and over 8.5 million UK birds have been lost/culled in that period, the impact of this has been seen by the consumer by the lack of eggs in the supermarket and turkeys for Christmas. A novel tool such as this could assist in future outbreak management -- reducing the economic burden and reducing the risk of bird flu becoming a human pathogen.The platform and associated validated tests would be made in the UK and marketed globally by BG, supporting growth and employment in UK Life Sciences and supply chains, while ensuring the UK is better prepared to respond to future epidemics of important human and animal pathogens.

项目的目的是提供早期现场直接检测未经处理的生物样本的能力，例如拭子和血液中具有经济意义的兽医病原体，在这种情况下，筛选从鸟类喙和泄殖腔中采集的拭子样本，以检测“禽流感”。最初我们的目标是支持现有的实验室检测，并最终探索将检测转移到田间或农场的可能性。BG Research开发了一种新的方法和仪器，用于进行敏感的田间分子诊断检测，以检测病毒，而无需专家科学家或将样本运送到检测实验室，并利用金标准PCR检测方法。可以在入境口岸进行检测，以防止疾病输入，也可以在农场或屠宰场进行检测，以支持监测/检疫和应急反应。通过在需要的地方进行快速、敏感和具有成本效益的检测，生物遗传资源研究所的技术可以通过防止入境点潜在的传染病输入来帮助保护联合王国，并在入侵需要快速疾病应对活动的情况下加快疫情应对。例如，英国爆发的口蹄疫使经济损失100亿英镑，而COVID-19被认为起源于野生动物。这种技术可以帮助Defra更有效地监测跨界兽医疾病，并提供实时数据，以帮助控制这些疾病，减少未来爆发的社会经济影响。我们将把该平台从实验室技术演示器发展成为能够离网运行的后期原型，并使该技术更接近预期的便携式检测市场。试验开发评估将在动植物卫生署（APHA）进行，该机构拥有处理这些病原体所需的必要科学专业知识和设施。在过去的几年里，禽流感一直在新闻中不断报道，在此期间，英国有850多万只家禽被丢失/扑杀，消费者已经看到了这一影响，因为超市里没有鸡蛋，圣诞节也没有火鸡。这样一个新的工具可以帮助未来的疫情管理-减少经济负担和降低禽流感成为人类病原体的风险。该平台和相关的验证测试将在英国制造，并由BG在全球销售，支持英国生命科学和供应链的增长和就业，同时确保英国更好地准备应对未来重要的人类和动物病原体的流行。