Demonstrating the potential for portable detection of bird flu.

展示便携式检测禽流感的潜力。

• 批准号: 10090901
• 金额: $ 26.62万
• 依托单位: B G RESEARCH LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10090901
• 关键词: Demonstrating; potential; portable; detection; bird

Project aim is to provide capability for early in-field direct testing of unprocessed biological samples e.g. swabs and blood for economically important veterinary pathogens, in this case screening swab samples taken from the beaks and cloaca of birds for detecting "bird flu". Initially we aim to support existing lab testing and ultimately explore the potential for moving tests into the field or farm.BG Research have developed a novel method and instrument for performing sensitive in-field molecular diagnostic tests for the detection of viruses without the requirement for expert scientists or shipping of samples to a test-lab and utilising the gold-standard PCR test methodology. Tests could be performed at ports of entry to prevent diseases being imported, on farms or at slaughterhouses to support surveillance/quarantine and emergency response.By performing rapid, sensitive, and cost-effective tests wherever required, the BGR technology could help protect the UK by preventing potential importation of infectious diseases at entry points and expedite outbreak response where incursions require rapid disease response activities. For example, the outbreaks of FMD in the UK cost the economy £10bn and COVID-19 is thought to have originated from wildlife. Such technology could assist Defra to more effectively monitor transboundary veterinary diseases and provide real-time data to contribute to the control of these diseases, reducing the socio-economic impacts of future outbreaks.We will develop the platform from a lab-based technology demonstrator into a late-stage prototype capable of being operated off-grid and moving the technology closer to the intended portable testing market. Test development assessment will be undertaken at the Animal and Plant Health Agency (APHA) where the necessary scientific expertise and facilities required to work with these pathogens are available. Bird flu has been in the news continually for the past few years and over 8.5 million UK birds have been lost/culled in that period, the impact of this has been seen by the consumer by the lack of eggs in the supermarket and turkeys for Christmas. A novel tool such as this could assist in future outbreak management -- reducing the economic burden and reducing the risk of bird flu becoming a human pathogen.The platform and associated validated tests would be made in the UK and marketed globally by BG, supporting growth and employment in UK Life Sciences and supply chains, while ensuring the UK is better prepared to respond to future epidemics of important human and animal pathogens.

项目的目的是为未经处理的生物样品（例如拭子和血液用于经济上重要的兽医病原体，在这种情况下，从鸟类和鸟泄殖物中筛选拭子样品，用于检测“鸟流感”。最初，我们旨在支持现有的实验室测试，并最终探索将测试转移到现场或农场的潜力。BG研究开发了一种新颖的方法和工具，用于执行敏感的现场分子诊断测试，以检测病毒，而无需专家科学家或运输样品来测试LAB并利用金标准PCR测试方法。可以在入境口岸进行测试，以防止在农场或屠宰场进口疾病，以支持监视/隔离和紧急响应。通过在需要的任何地方进行快速，敏感和具有成本效益的测试，BGR技术可以通过防止在入口和加速疾病的疾病中进行潜在的进口疾病来保护英国，从而迅速疾病迅速采取侵害疾病的疾病。例如，英国FMD的爆发使经济损失了100亿英镑，而Covid-19的爆发被认为是源自野生动植物的。这种技术可以帮助Defra更有效地监测跨界兽医疾病并提供实时数据以有助于控制这些疾病，从而减少未来爆发的社会经济影响。我们将开发从基于实验室的技术演示器到能够操作的后期原型的平台，并将其转移到网络上，并将其转移到近期的技术中，并将其转移到预期的端口端口上。测试开发评估将在动物和植物健康局（APHA）进行，其中可用的这些病原体所需的必要科学专业知识和设施。在过去的几年中，鸟流感一直在新闻中持续不断，在那个时期，超过850万英国的鸟类已经丢失/扑灭了，消费者已经看到了超市中缺少鸡蛋和圣诞节的火鸡。这样的新颖工具可以帮助未来的爆发管理 - 降低经济伯恩伯恩并降低了鸟类流感成为人类病原体的风险。平台和相关的经过验证的测试将在英国进行，并由BG在全球范围内进行，从而支持英国生命科学和供应链的增长和就业，同时确保英国能够更好地响应重要的人类和动物恋人的恋情。