Collaborative Pediatric Critical Care Research Network - Clinical Site

项目摘要-加州大学联盟 加州大学旧金山分校贝尼奥夫儿童医院一直是 尤尼斯·肯尼迪·施莱弗国家儿童健康与发展研究院儿科协作组 重症监护研究网络(CPCCRN)自2014年(第三周期)以来，并热衷于作为 在新组织和扩大的网络中的临床中心。在第三个周期中，Anil Sapru博士(原PI) 搬迁到加州大学洛杉矶分校(UCLA)，加州大学洛杉矶分校作为联合体加入加州大学洛杉矶分校。更多 最近，加州大学旧金山分校附属于前奥克兰儿童医院，成立了新的贝尼奥夫儿童医院 旧金山(BCHSF)和奥克兰(BCHO)医院。因此，BCHSF和BCHO以及加州大学洛杉矶分校将 在本站点申请中包括临床联盟或中心站点。我们将与我们的助手密切合作 加州大学戴维斯分校儿童医院。与该合作伙伴相结合，我们的网站将提供 获得104张PICU床位，每年约有4500人入院，使我们能够全面参与 “脓毒症诱导的多器官功能障碍综合征的个性化免疫调节”试验在这篇文章的总体部分中描述 申请。我们的选址方案有三个具体目标：具体目标1.积极配合实施 协调中心的工作，包括参加指导委员会和其他委员会，出席会议， 促进与数据协调中心签订合同，并遵守标准操作 网络的流程和性能预期。具体目标2.为年轻人提供机会 调查人员参加CPCCRN的会议、委员会或试验实施，目标是 将这些有才华的人培养成可资助的临床医生科学家。具体目标3.落实 脓毒症诱导的多器官功能障碍综合征试验中的个性化免疫调节，包括受训患者的登记 研究人员，遵守研究方案，及时输入数据，并完全遵守良好临床 实践(GCP)和其他法规要求。

PROJECT ABSTRACT - University of California Consortium The University of California, San Francisco (UCSF) Benioff Children's Hospital has been a Clinical Site in the Eunice Kennedy Shriver National Institutes of Child Health and Development (NICHD) Collaborative Pediatric Critical Care Research Network (CPCCRN) since 2014 (3rd cycle) and is enthusiastic about participating as a Clinical Hub in the newly organized and expanded network. During the 3rd cycle, Dr Anil Sapru (original PI) relocated to University of California, Los Angeles (UCLA) and UCLA joined UCSF as a consortium site. More recently UCSF has affiliated with the former Children's Hospital Oakland resulting in the new Benioff Children's Hospitals at San Francisco (BCHSF) and Oakland (BCHO). Thus, BCHSF and BCHO, along with UCLA, will comprise a clinical consortium or hub site in the present site application. We will work closely with our ancillary site, University of California, Davis Children's Hospital. In combination with this partner, our site will provide access to 104 PICU beds with approximately 4500 annual admissions, enabling us to participate fully in the “Personalized Immunomodulation in Sepsis-induced MODS” trial described in the Overall Component of this application. Our site proposal has three specific aims: Specific Aim 1. Actively collaborate in implementation of CPCCRN, including participation on the Steering Committee and other committees, attendance at meetings, facilitating contracting with the Data Coordinating Center, and complying with the standard operating procedures and performance expectations of the network. Specific Aim 2. Provide opportunities for young investigators to participate in CPCCRN meetings, committees, or trial implementation, with the goal of developing these talented individuals into fundable clinician scientists. Specific Aim 3. Implement the Personalized Immunomodulation in Sepsis-induced MODS trial, including enrollment of patients by trained research staff, adhering to the study protocol, prompt data entry, and full compliance with Good Clinical Practice (GCP) and other regulatory requirements.