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Collaborative Pediatric Critical Care Research Network - Clinical Site

儿科重症监护协作研究网络 - 临床网站

基本信息

批准号：
10248820
负责人：
Patrick Sean McQuillen
金额：
$ 8.18万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-13 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10248820
关键词：
Address Admission activity Ancillary Study Award Beds Biological Markers Brain Injuries California Child Child Development Child Health Childhood Clinical Clinical Research Clinical Trials Coagulation Process Contracts Critical Care Critical Illness Data Data Coordinating Center Databases Faculty Family Funding Gene Expression Geography Goals Good Clinical Practice Health Hypoxemia Immune response Immunocompromised Host Individual Infant Inflammation Institutes Lead Los Angeles Lung Machine Learning Manuscripts Mentors Morbidity - disease rate Multi-Institutional Clinical Trial National Heart, Lung, and Blood Institute Natural Language Processing Network Infrastructure Nurses Obesity Outcome Pediatric Acute Lung Injury Pediatric Hospitals Performance Physiology Population Procedures Protocols documentation Publishing Recording of previous events Research Research Personnel Research Training Respiratory Failure Risk San Francisco Scientist Sepsis Site Talents United States National Institutes of Health Universities Work base clinical research site design early-career faculty expectation experience immunoregulation innovation lung microbiome meetings metabolomics metatranscriptomics mortality outcome prediction participant enrollment programs prospective racial and ethnic racial diversity success ward

项目摘要

PROJECT ABSTRACT - University of California Consortium The University of California, San Francisco (UCSF) Benioff Children's Hospital has been a Clinical Site in the Eunice Kennedy Shriver National Institutes of Child Health and Development (NICHD) Collaborative Pediatric Critical Care Research Network (CPCCRN) since 2014 (3rd cycle) and is enthusiastic about participating as a Clinical Hub in the newly organized and expanded network. During the 3rd cycle, Dr Anil Sapru (original PI) relocated to University of California, Los Angeles (UCLA) and UCLA joined UCSF as a consortium site. More recently UCSF has affiliated with the former Children's Hospital Oakland resulting in the new Benioff Children's Hospitals at San Francisco (BCHSF) and Oakland (BCHO). Thus, BCHSF and BCHO, along with UCLA, will comprise a clinical consortium or hub site in the present site application. We will work closely with our ancillary site, University of California, Davis Children's Hospital. In combination with this partner, our site will provide access to 104 PICU beds with approximately 4500 annual admissions, enabling us to participate fully in the “Personalized Immunomodulation in Sepsis-induced MODS” trial described in the Overall Component of this application. Our site proposal has three specific aims: Specific Aim 1. Actively collaborate in implementation of CPCCRN, including participation on the Steering Committee and other committees, attendance at meetings, facilitating contracting with the Data Coordinating Center, and complying with the standard operating procedures and performance expectations of the network. Specific Aim 2. Provide opportunities for young investigators to participate in CPCCRN meetings, committees, or trial implementation, with the goal of developing these talented individuals into fundable clinician scientists. Specific Aim 3. Implement the Personalized Immunomodulation in Sepsis-induced MODS trial, including enrollment of patients by trained research staff, adhering to the study protocol, prompt data entry, and full compliance with Good Clinical Practice (GCP) and other regulatory requirements.

项目摘要-加州大学联盟