Core 3 Non Human Primate Studies

辐射对策卓越研究中心 核心3：灵长类动物研究 摘要 灵长类动物研究核心促进了对缓解剂的后期临床前研究的进行。 非人类灵长类动物（NHP）的辐射损伤，遵循RadCCORE的具体优先事项 与全国其他CMCR共享组织和数据。由于高度的 非人类灵长类动物与人类的遗传和生理相似性，这种资源是一种关键的 在实验环境中对候选可交付试剂进行翻译评估的组成部分 在该剂量下，可以对健康受试者给予相关剂量的全身照射。核心 研究人员在非人灵长类动物的实验使用和临床医学方面具有独特的技能， 包括辐射、兽医医疗护理和骨髓抑制动物的管理， 灵长类比较病理学、放射损伤病理学、生物化学、临床病理学和 灵长类动物的内分泌学，以及分子生物学技术对灵长类动物模型的适应。核心 服务包括研究规划、监管批准、特定- 无病原体的非人灵长类动物，动物暴露于辐射，治疗药物的施用 干预措施，以及治疗结果的临床和病理评估，包括 尸检/组织收集和共享，用于辐射反应的基线表征， 评估缓解干预措施。Core还提供广泛的数据管理服务 灵长类动物研究，包括数据共享和与生物统计核心互动，以促进分析 并公布调查结果。拟议供资期间的主要核心用户将是项目3 FSL-1 作为GI和造血缓解剂，但所有项目都将通过共享组织，液体 设计和审查未来前瞻性研究的计划。

Radiation Countermeasures Center of Research Excellence Core 3: Primate Studies Abstract The Primate Studies Core facilitates the conduct of late-stage preclinical studies of mitigators of radiation damage in nonhuman primates (NHP), following the specific priorities of the RadCCORE consortium and sharing tissue and data with other CMCRs nationwide. Because of the high degree of genetic and physiologic similarity of nonhuman primates to human beings, this resource is a critical component of translational assessment of candidate deliverable agents, in an experimental setting under which relevant doses of whole-body irradiation can be given to healthy subjects. Core investigators have unique skills in the experimental use and clinical medicine of nonhuman primates, including irradiation, veterinary medical care and management of myelosuppressed animals, comparative pathology of primates, pathology of radiation injury, biochemistry, clinical pathology and endocrinology of primates, and adaptation of molecular biologic techniques to the primate model. Core services include study planning, regulatory approvals, acquisition and maintenance of specific- pathogen-free nonhuman primates, exposure of animals to radiation, administration of therapeutic interventions, and clinical and pathologic assessments of treatment outcomes, including necropsy/tissue collection and sharing for baseline characterization of radiation responses and assessment of mitigating interventions. The Core also provides extensive data management services for primate studies, including data sharing and interaction with the biostatistics core to facilitate analysis and publication of findings. The main core user for the proposed funding period will be Project 3, FSL-1 as a GI and hematopoietic mitigator, but all Projects will be served, through sharing of tissues, fluids and data; design and review of plans for future prospective studies.