Primate Studies

灵长类动物研究

基本信息

批准号：
8013125
负责人：
J. MARK CLINE
金额：
$ 121.25万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-01 至 2015-07-31
项目状态：
已结题

项目摘要

The Primate Stutiies Core facilitates the conduct of late-stage preclinical studies of mitigators of radiation damage in nonhuman primates, following the specific priorities of the RadCCORE consortium and other CMCRs nationwide, including since 2007 long-term care and study of animals surviving high-dose irradiation at other institutions. Because of the high degree of genetic and physiologic similarity of nonhuman primates to human beings, this resource is a critical component of translational assessment of candidate deliverable agents, in an experimental setting under which relevant doses of whole-body irradiation can be given to healthy subjects. Core investigators have unique skills in the experimental use and clinical medicine of nonhuman primates, including irradiation, veterinary medical care and management of myelosuppressed animals, comparative pathology of primates, pathology of radiation injury, biochemistry, clinical pathology and endocrinology of primates, and adaptation of molecular biologic techniques to the primate model. Core services include acquisition and maintenance of specific-pathogen-free nonhuman primates, exposure of animals to radiation, administration of therapeutic interventions, and clinical and pathologic assessments of treatment outcomes, including necropsy/tissue collection and sharing for baseline characterization of radiation responses and assessment of mitigating interventions. The Core also provides extensive data management services for primate studies, including data and tissue sharing.

灵长类动物核心核心促进了辐射缓解剂的后期临床前研究非人类灵长类动物的损害，遵循Radccore财团和其他CMCR的特定优先级在全国范围内，包括自2007年以来的长期护理和对其他在其他高剂量照射下的动物的研究机构。由于非人类灵长类动物与人类的遗传和生理相似性高度生物，此资源是候选人可交付代理转化评估的关键组成部分，实验环境下，可以将相关剂量的全身照射给予健康受试者。核心研究人员在非人类灵长类动物的实验用途和临床医学方面具有独特的技能，包括辐照，兽医医疗和骨髓抑制动物的管理，比较灵长类动物的病理学，辐射损伤的病理学，生物化学，临床病理和内分泌学灵长类动物，以及分子生物学技术对灵长类动物模型的适应。核心服务包括采集和维持没有特定无性疾病的非人类灵长类动物，动物暴露于辐射，治疗干预措施，治疗结果的临床和病理评估，包括尸检/组织收集和共享辐射反应的基线表征和共享评估缓解干预措施。核心还为灵长类动物提供广泛的数据管理服务研究，包括数据和组织共享。