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Primate Studies

灵长类动物研究

基本信息

批准号：
8013125
负责人：
J. MARK CLINE
金额：
$ 121.25万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-01 至 2015-07-31
项目状态：
已结题

项目摘要

The Primate Stutiies Core facilitates the conduct of late-stage preclinical studies of mitigators of radiation damage in nonhuman primates, following the specific priorities of the RadCCORE consortium and other CMCRs nationwide, including since 2007 long-term care and study of animals surviving high-dose irradiation at other institutions. Because of the high degree of genetic and physiologic similarity of nonhuman primates to human beings, this resource is a critical component of translational assessment of candidate deliverable agents, in an experimental setting under which relevant doses of whole-body irradiation can be given to healthy subjects. Core investigators have unique skills in the experimental use and clinical medicine of nonhuman primates, including irradiation, veterinary medical care and management of myelosuppressed animals, comparative pathology of primates, pathology of radiation injury, biochemistry, clinical pathology and endocrinology of primates, and adaptation of molecular biologic techniques to the primate model. Core services include acquisition and maintenance of specific-pathogen-free nonhuman primates, exposure of animals to radiation, administration of therapeutic interventions, and clinical and pathologic assessments of treatment outcomes, including necropsy/tissue collection and sharing for baseline characterization of radiation responses and assessment of mitigating interventions. The Core also provides extensive data management services for primate studies, including data and tissue sharing.

Primate Studiies Core促进了辐射缓解剂的后期临床前研究非人灵长类动物的损害，遵循RadCCORE联盟和其他CMCR的具体优先事项在全国范围内，包括自2007年以来对在其他国家高剂量辐照下存活的动物进行长期护理和研究，机构职能体系由于非人类灵长类动物与人类在遗传和生理上高度相似，存在，这个资源是候选可交付代理翻译评估的关键组成部分，在一个在这种实验环境下，可以对健康受试者进行相关剂量的全身照射。核心研究人员在非人灵长类动物的实验使用和临床医学方面具有独特的技能，包括辐射、兽医医疗护理和骨髓抑制动物的管理，灵长类病理学、放射损伤病理学、生物化学、临床病理学和内分泌学灵长类动物，以及分子生物学技术对灵长类动物模型的适应。核心服务包括获得和维持无特定病原体的非人灵长类动物，动物暴露于辐射，治疗干预的实施，以及治疗结果的临床和病理评估，包括尸检/组织收集和共享，用于辐射反应的基线表征，评估缓解干预措施。Core还为灵长类动物提供广泛的数据管理服务研究，包括数据和组织共享。