Core--(Primate Studies) Radiation countermeasure center

核心--（灵长类研究）辐射对策中心

• 批准号: 7052931
• 负责人: J. MARK CLINE
• 金额: $ 64.34万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7052931
• 关键词: Macaca fascicularis; animal care; biomedical facility; cooperative study; ionizing radiation; radiation dosage; radiation protection; radiation recovery

This project is a Primate Studies Core for a multi-institutional Radiation Countermeasures Consortium.The Core will help conduct studies of drugs that may protect the health of people exposed to radiation, as in the case of a terrorist attack involving a "dirty bomb" or nuclear bomb. Because of the high degree of genetic and functional similarity between nonhuman primates and human beings, this core resource is a critical component of candidate radiation-protective drugs, in an experimental setting under which radiation can be given to healthy subjects (which cannot be done in people). This core will serve programs in Normal Tissue Injury, Bone Marrow Recovery, and Immunity programs. Core investigators have unique skills in the experimental use and clinical medicine of nonhuman primates including irradiation; veterinary medical care and management of bone-marrow-suppressed animals; diseases of primates; pathology of radiation injury; blood testing and hormonal regulation in primates; and adaptation of genetic techniques to the primate model. Core services will include acquisition and maintenance of disease-free primates, exposure of animals to radiation, administration of therapeutic interventions to prevent radiation damage, and clinical and pathologic assessments of treatment outcomes in nonhuman primates, including post-mortem examination and tissue collection and sharing for both baseline characterization of radiation responses and assessment of mitigating interventions. The Core will also provide extensive data management services for primate studies including data sharing.

该项目是一个多机构辐射对抗联盟的灵长类动物研究核心。该中心将帮助开展药物研究，以保护暴露在辐射下的人们的健康，例如在涉及“脏弹”或核弹的恐怖袭击中。由于非人类灵长类动物与人类之间的遗传和功能高度相似，这一核心资源是候选辐射防护药物的关键组成部分，在实验环境下，可以对健康受试者进行辐射（不能对人类进行辐射）。该核心将服务于正常组织损伤，骨髓恢复和免疫项目。核心研究人员在非人类灵长类动物的实验使用和临床医学方面具有独特的技能，包括辐照；兽医保健