Core--(Primate Studies) Radiation countermeasure center

该项目是多机构辐射对策联合会的灵长类研究核心项目，将帮助进行药物研究，以保护受到辐射的人的健康，如涉及“脏弹”或核弹的恐怖袭击的情况。由于非人类灵长类动物和人类之间的遗传和功能高度相似，这种核心资源是候选辐射防护药物的关键组成部分，在实验环境下，可以对健康受试者进行辐射（这不能在人类身上进行）。这个核心将服务于正常组织损伤，骨髓恢复和免疫程序的程序。核心研究人员在非人灵长类动物的实验使用和临床医学方面具有独特的技能，包括辐照;兽医医疗护理 研究领域包括骨髓抑制动物的治疗和管理;灵长类动物疾病;辐射损伤病理学;灵长类动物的血液检测和激素调节;以及使遗传技术适应灵长类动物模型。核心服务将包括获取和维持无病灵长类动物、使动物暴露于辐射、实施治疗干预措施以防止辐射损伤，以及对非人灵长类动物的治疗结果进行临床和病理评估，包括尸检和组织收集，并分享辐射反应的基线特征和缓解干预措施的评估。Core还将为灵长类动物提供广泛的数据管理服务 研究包括数据共享。

This project is a Primate Studies Core for a multi-institutional Radiation Countermeasures Consortium.The Core will help conduct studies of drugs that may protect the health of people exposed to radiation, as in the case of a terrorist attack involving a "dirty bomb" or nuclear bomb. Because of the high degree of genetic and functional similarity between nonhuman primates and human beings, this core resource is a critical component of candidate radiation-protective drugs, in an experimental setting under which radiation can be given to healthy subjects (which cannot be done in people). This core will serve programs in Normal Tissue Injury, Bone Marrow Recovery, and Immunity programs. Core investigators have unique skills in the experimental use and clinical medicine of nonhuman primates including irradiation; veterinary medical care and management of bone-marrow-suppressed animals; diseases of primates; pathology of radiation injury; blood testing and hormonal regulation in primates; and adaptation of genetic techniques to the primate model. Core services will include acquisition and maintenance of disease-free primates, exposure of animals to radiation, administration of therapeutic interventions to prevent radiation damage, and clinical and pathologic assessments of treatment outcomes in nonhuman primates, including post-mortem examination and tissue collection and sharing for both baseline characterization of radiation responses and assessment of mitigating interventions. The Core will also provide extensive data management services for primate studies including data sharing.