Reducing the Impact of Rheumatic Heart Disease across the Life Span: The Impact Program

减少风湿性心脏病对整个生命周期的影响：影响计划

• 批准号: 10469186
• 负责人: Andrea Zawacki Beaton
• 金额: $ 24.41万
• 依托单位: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10469186
• 关键词: Address; Advisory Committees; Africa South of the Sahara; African; Caring; Child; Clinical Trials; Collaborations; Country; Degree program; Disease; Doctor of Philosophy; E-learning; Early Diagnosis; Educational workshop; Ensure; Fellowship; Funding; Gender; Generations; Goals; Grant; Guidelines; Health; Heart; Hospitals; Immersion; Income; Institutes; Knowledge; Longevity; Medical center; Medicine; Mentors; Pediatric Hospitals; Persons; Policies; Research; Research Activity; Research Personnel; Research Training; Resources; Rheumatic Heart Disease; Training; Training Activity; Training Programs; Training Support; Translating; Uganda; United States National Institutes of Health; Universities; Vision; Woman; burden of illness; career development; experience; heart disease prevention; improved; innovation; low and middle-income countries; medical schools; next generation; parity; professor; programs; recruit; sex; success; webinar

This application seeks funding for a D43 training grant to support a world-first rheumatic heart disease (RHD) research training program in Uganda. There has been little innovation globally in RHD prevention, early detection, and management since the mid-1900’s. Additionally, the majority of evidence guiding current practice was generated in high-income countries and may not translate directly to the contemporary burden of disease in low- and middle-income countries (LMICs). The Impact Mentored Research-Training Program will leverage existing resources and ongoing RHD clinical trials from a decade-long RHD research and training collaboration between Makerere University, the Uganda Heart Institute (UHI), Cincinnati Children’s Hospital Medical Centre (CCHMC) and Children’s National Hospital (CNH) to build capacity to tackle RHD where the burden is the highest. Our overarching objective is to equip and nurture emerging research leaders and professional scholars in Uganda to generate high-quality contemporary evidence on RHD across the lifespan and to create an enduring research training center on the African continent that will rapidly advance progress towards the elimination of the disease in a generation; a bold, but achievable goal. This application will provide critical support for the training, and research activities needed to realize this vision. The program will be led by Dr. Nelson Sewankambo, a Professor of Medicine and Former Dean of the Makerere University School of medicine, who has led several NIH and non-NIH research capacity building grants in Uganda and sub-Saharan Africa. Co-directing this program are the co- Directors of the Rheumatic Heart Disease Research Collaborative in Uganda (RRCU), Drs. Emmy Okello (UHI) and Andrea Beaton (CCHMC). Long-term degree training at Master’s, PhD and Career development fellowship levels will be offered, with primary coursework to occur in Uganda at MakCHS. CNH will provide both e-learning seminar and in-person immersive experience in the US to strengthen clinical trials capacity and improve trainee’s knowledge of gender parity and sex- and gender considerations in health research. Additionally, recruitment will target trainees from the regional centers to build National RHD capacity and ensure at least 50% of our trainees are women. Short-term trainings, seminars, webinars and workshops will be offered to degree and non-degree trainees to further strengthen institutional and national RHD- research capacity and to identify promising candidates for degree programs. A Steering Committee and the Training Advisory Committee (TAC) comprised of leading researchers with expertise in our objectives will both offer expert advice to the Impact Directors to ensure success of the trainees and the overall program by producing high-quality and locally relevant research. This success will translate into improving guidelines and policies for RHD care in Uganda and the region, training the next generation of excellent African researchers to address RHD prevention, early detection, and management.

此申请寻求D43培训补助金的资金，以支持世界首例风湿性心脏病 (RHD)乌干达的研究培训项目。全球在风湿性心脏病预防方面几乎没有创新， 早期发现和管理自20世纪中期以来。此外，大多数证据表明， 目前的做法是在高收入国家产生的，可能不会直接转化为当代的做法。 低收入和中等收入国家（LMIC）的疾病负担。影响指导的研究培训 该计划将利用现有资源和来自长达十年的RHD研究的正在进行的RHD临床试验 Makerere大学、乌干达心脏研究所（UHI）、辛辛那提 儿童医院医疗中心和国家儿童医院进行能力建设， 在负担最重的地方解决RHD问题。我们的首要目标是装备和培养新兴的 研究领导人和专业学者在乌干达产生高质量的当代证据， RHD的整个生命周期，并在非洲大陆建立一个持久的研究培训中心， 将在一代人的时间内迅速推动消除这种疾病的进展;一个大胆但可实现的 目标.该应用程序将为实现以下目标所需的培训和研究活动提供关键支持： 这个愿景。该项目将由医学教授纳尔逊·塞万坎博博士领导 马凯雷雷大学医学院前院长，他领导了几个NIH和非NIH的 乌干达和撒哈拉以南非洲的研究能力建设赠款。共同指导这个节目的是共同- 乌干达风湿性心脏病研究合作组织（RRCU）主任Emmy Okello博士 (UHI)Andrea Beaton（CCHMC）硕士、博士和职业发展的长期学位培训 将提供研究金级别，主要课程将在乌干达MakCHS进行。CNH将提供 在美国举办电子学习研讨会和亲身体验，以加强临床试验能力 提高受训人员对卫生研究中的两性均等以及性别和性别考虑因素的认识。 此外，招聘将针对来自区域中心的受训人员，以建设国家排雷能力， 确保至少50%的受训人员为女性。短期培训、研讨会、网络研讨会和讲习班 将提供给学位和非学位学员，以进一步加强机构和国家RHD- 研究能力，并确定有前途的候选人学位课程。一个指导委员会和 培训咨询委员会（TAC）由在我们的目标方面具有专业知识的领先研究人员组成 将为影响主任提供专家建议，以确保学员和整体的成功 通过生产高质量和本地相关的研究计划。这一成功将转化为改善 乌干达和该地区RHD护理的指导方针和政策，培训下一代优秀的 非洲研究人员致力于风湿性心脏病的预防、早期发现和管理。