Reducing the Impact of Rheumatic Heart Disease across the Life Span: The Impact Program

减少风湿性心脏病对整个生命周期的影响：影响计划

• 批准号: 10594560
• 负责人: Andrea Zawacki Beaton
• 金额: $ 24.24万
• 依托单位: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10594560
• 关键词: Address; Advisory Committees; Africa South of the Sahara; African; Caring; Child; Clinical Trials; Collaborations; Country; Degree program; Disease; Doctor of Philosophy; E-learning; Early Diagnosis; Educational workshop; Ensure; Fellowship; Funding; Gender; Generations; Goals; Grant; Guidelines; Health; Heart; Hospitals; Income; Institution; Knowledge; Longevity; Medical center; Medicine; Mentors; Pediatric Hospitals; Persons; Policies; Research; Research Activity; Research Personnel; Research Training; Resources; Rheumatic Heart Disease; Training; Training Activity; Training Programs; Training Support; Translating; Uganda; United States National Institutes of Health; Universities; Vision; Woman; burden of illness; career development; experience; heart disease prevention; improved; innovation; low and middle-income countries; medical schools; next generation; parity; professor; programs; recruit; sex; success; webinar

This application seeks funding for a D43 training grant to support a world-first rheumatic heart disease (RHD) research training program in Uganda. There has been little innovation globally in RHD prevention, early detection, and management since the mid-1900’s. Additionally, the majority of evidence guiding current practice was generated in high-income countries and may not translate directly to the contemporary burden of disease in low- and middle-income countries (LMICs). The Impact Mentored Research-Training Program will leverage existing resources and ongoing RHD clinical trials from a decade-long RHD research and training collaboration between Makerere University, the Uganda Heart Institute (UHI), Cincinnati Children’s Hospital Medical Centre (CCHMC) and Children’s National Hospital (CNH) to build capacity to tackle RHD where the burden is the highest. Our overarching objective is to equip and nurture emerging research leaders and professional scholars in Uganda to generate high-quality contemporary evidence on RHD across the lifespan and to create an enduring research training center on the African continent that will rapidly advance progress towards the elimination of the disease in a generation; a bold, but achievable goal. This application will provide critical support for the training, and research activities needed to realize this vision. The program will be led by Dr. Nelson Sewankambo, a Professor of Medicine and Former Dean of the Makerere University School of medicine, who has led several NIH and non-NIH research capacity building grants in Uganda and sub-Saharan Africa. Co-directing this program are the co- Directors of the Rheumatic Heart Disease Research Collaborative in Uganda (RRCU), Drs. Emmy Okello (UHI) and Andrea Beaton (CCHMC). Long-term degree training at Master’s, PhD and Career development fellowship levels will be offered, with primary coursework to occur in Uganda at MakCHS. CNH will provide both e-learning seminar and in-person immersive experience in the US to strengthen clinical trials capacity and improve trainee’s knowledge of gender parity and sex- and gender considerations in health research. Additionally, recruitment will target trainees from the regional centers to build National RHD capacity and ensure at least 50% of our trainees are women. Short-term trainings, seminars, webinars and workshops will be offered to degree and non-degree trainees to further strengthen institutional and national RHD- research capacity and to identify promising candidates for degree programs. A Steering Committee and the Training Advisory Committee (TAC) comprised of leading researchers with expertise in our objectives will both offer expert advice to the Impact Directors to ensure success of the trainees and the overall program by producing high-quality and locally relevant research. This success will translate into improving guidelines and policies for RHD care in Uganda and the region, training the next generation of excellent African researchers to address RHD prevention, early detection, and management.

该应用程序寻求资助D43培训补助金，以支持世界第一的风湿性心脏病 （RHD）乌干达的研究培训计划。在RHD预防方面，全球几乎没有创新， 自1900年代中期以来的早期检测和管理。此外，大多数证据指导 当前的实践是在高收入国家产生的，可能不会直接转化为当代 低收入和中等收入国家（LMIC）的疾病负担。影响指导了研究培训 计划将利用十年的RHD研究中的现有资源和正在进行的RHD临床试验 以及辛辛那提乌干达心脏研究所（UHI），乌干达心脏研究所（UHI）之间的培训合作 儿童医院医疗中心（CCHMC）和儿童国家医院（CNH），以建立能力 应对RHD，其中燃烧最高。我们的总体目标是装备和护理 乌干达的研究领袖和专业学者，以产生高质量的当代证据 RHD在整个生命周期中，并在非洲大陆建立一个持久的研究培训中心 将迅速促进一代人消除疾病的进展；大胆但可以实现的 目标。该应用程序将为培训提供关键的支持，以及所需的研究活动 这个愿景。该计划将由医学教授Nelson Sewankambo博士领导 以及Makerere大学医学院的前院长，他领导了几名NIH和非NIH 乌干达和撒哈拉以南非洲的研究能力建设赠款。共同指导该计划是共同的 乌干达（RRCU）风湿性心脏病研究合作的董事，博士。艾米·奥克洛（Emmy Okello） （UHI）和Andrea Beaton（CCHMC）。硕士，博士和职业发展的长期学位培训 将提供奖学金水平，将在穆加奇的乌干达进行主要课程。 CNH将提供 在美国，电子学习半年度和面对面的沉浸式体验都可以增强临床试验能力 并提高受训者对健康研究中性别平等以及性别和性别考虑因素的了解。 此外，招聘将针对来自地区中心的受训人员，以建立国家RHD的能力和 确保至少有50％的学员是女性。短期培训，半手级，网络研讨会和研讨会 将提供学位和非学位学员，以进一步加强机构和国家RHD- 研究能力并确定候选学位课程的承诺。指导委员会和 培训咨询委员会（TAC）完成了领先的研究人员，具体知识 两者都将向Impact Director提供专家建议，以确保培训的成功和整体 通过生产高质量和本地相关的研究来计划。这种成功将转化为改善 乌干达和该地区RHD护理的指南和政策，培训下一代优秀 非洲研究人员解决RHD预防，早期检测和管理。