Human mitochondrial ACP interactions
人类线粒体 ACP 相互作用
基本信息
- 批准号:10469436
- 负责人:
- 金额:$ 19.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-15 至 2024-12-31
- 项目状态:已结题
- 来源:
- 关键词:Acyl Carrier ProteinAdoptedAgingAmino Acid MotifsAmino Acid SequenceAnabolismArginineBehaviorBindingBiochemicalBiochemical PathwayBiogenesisBiologyCalorimetryCaprylatesChemicalsComplexCryoelectron MicroscopyDataDepositionDifferential Scanning CalorimetryDiseaseEnzymesEscherichia coliEventFatty AcidsFatty-acid synthaseGoalsHealthHumanInterferometryIronKnowledgeLabelLengthLeucineLipidsMaintenanceMetabolic PathwayMetabolismMethodsMitochondriaMitochondrial DiseasesMitochondrial ProteinsMolecularMolecular ConformationNADH dehydrogenase (ubiquinone)Neurodegenerative DisordersPathway interactionsPeripheralPlayPost-Translational Protein ProcessingProductionPropertyProteinsReactive Oxygen SpeciesRegulationReportingRibosomesRoleScaffolding ProteinSeriesStructureSubstrate InteractionSubstrate SpecificitySulfurSurface Plasmon ResonanceSystemTechnologyThioctic AcidTitrationsTranslatingTranslationsTyrosineValidationage relatedanalogbasebiophysical techniquesbiophysical toolscysteine desulfurasedisease phenotypegenetic regulatory proteinmitochondrial metabolismpolyketide synthaseprogramsprotein protein interactionrespiratoryskillstool
项目摘要
7. Project Summary. Mitochondrial damage, and mitochondrial fatty acid synthase (mtFAS) disorders in
particular, have been associated with aging and neurodegenerative disease. Historically these disorders were
attributed to a decrease in lipoic acid production, however, this conclusion has recently come into question with
the growing evidence that the mitochondrial acyl carrier protein (mtACP), the substrate-shuttling protein of
mtFAS, plays a much greater role within mitochondrial metabolic pathways. A hierarchy of mtACP regulation,
from mitochondrial protein translation to respiratory complex assembly, has been recently revealed, however
the molecular basis of such control remains unclear. This program aims to apply new chemical, structural, and
biophysical tools to understand how acyl-mtACP interacts within the mitochondrial metabolism. Given the
central role of the mitochondria in cellular metabolism, this program will fundamentally impact our
understanding of aging and health maintenance and provide potential new avenues to treatment of
mitochondrial diseases.
7.项目摘要。线粒体损伤和线粒体脂肪酸合酶(mtFAS)疾病
特别是与衰老和神经退行性疾病有关。从历史上看,这些疾病
然而,这一结论最近受到质疑,
越来越多的证据表明,线粒体酰基载体蛋白(mtACP),底物穿梭蛋白,
mtFAS在线粒体代谢途径中起着更大的作用。mtACP调节的层次结构,
从线粒体蛋白质翻译到呼吸复合体组装,
这种控制的分子基础仍不清楚。该计划旨在应用新的化学,结构,
生物物理工具,以了解酰基-mtACP如何在线粒体代谢中相互作用。鉴于
线粒体在细胞代谢中的核心作用,这一计划将从根本上影响我们的
了解衰老和健康维护,并提供潜在的新途径,治疗
线粒体疾病
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Michael D. Burkart其他文献
Data from mass spectrometry, NMR spectra, GC–MS of fatty acid esters produced by <em>Lasiodiplodia theobromae</em>
- DOI:
10.1016/j.dib.2016.05.003 - 发表时间:
2016-09-01 - 期刊:
- 影响因子:
- 作者:
Carla C. Uranga;Joris Beld;Anthony Mrse;Iván Córdova-Guerrero;Michael D. Burkart;Rufina Hernández-Martínez - 通讯作者:
Rufina Hernández-Martínez
Reversal of malignant ADAR1 splice isoform switching with Rebecsinib
用 Rebecsinib 逆转恶性 ADAR1 剪接异构体转换
- DOI:
10.1016/j.stem.2023.01.008 - 发表时间:
2023-03-02 - 期刊:
- 影响因子:20.400
- 作者:
Leslie A. Crews;Wenxue Ma;Luisa Ladel;Jessica Pham;Larisa Balaian;S. Kathleen Steel;Phoebe K. Mondala;Raymond H. Diep;Christina N. Wu;Cayla N. Mason;Inge van der Werf;Isabelle Oliver;Eduardo Reynoso;Gabriel Pineda;Thomas C. Whisenant;Peggy Wentworth;James J. La Clair;Qingfei Jiang;Michael D. Burkart;Catriona H.M. Jamieson - 通讯作者:
Catriona H.M. Jamieson
Gating mechanism of elongating β-ketoacyl-ACP synthases
延伸β-酮脂酰-ACP 合酶的门控机制
- DOI:
10.1038/s41467-020-15455-x - 发表时间:
2020-04-07 - 期刊:
- 影响因子:15.700
- 作者:
Jeffrey T. Mindrebo;Ashay Patel;Woojoo E. Kim;Tony D. Davis;Aochiu Chen;Thomas G. Bartholow;James J. La Clair;J. Andrew McCammon;Joseph P. Noel;Michael D. Burkart - 通讯作者:
Michael D. Burkart
The Complete Characterization of a Trapped ACYL Carrier Protein-Ketosynthase Complex
- DOI:
10.1016/j.bpj.2019.11.1114 - 发表时间:
2020-02-07 - 期刊:
- 影响因子:
- 作者:
Jeffrey T. Mindrebo;Laetitia E. Misson;Ashay Patel;Katia Charov;Joseph P. Noel;Michael D. Burkart - 通讯作者:
Michael D. Burkart
Crosslinking intermodular condensation in non-ribosomal peptide biosynthesis
非核糖体肽生物合成中的交联模块间缩合
- DOI:
10.1038/s41586-024-08306-y - 发表时间:
2024-12-11 - 期刊:
- 影响因子:48.500
- 作者:
Graham W. Heberlig;James J. La Clair;Michael D. Burkart - 通讯作者:
Michael D. Burkart
Michael D. Burkart的其他文献
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{{ truncateString('Michael D. Burkart', 18)}}的其他基金
Targeting Metal-Dependent Epigenetic Modulators via MetalloPROTACs
通过 MetalloPROTAC 靶向金属依赖性表观遗传调节剂
- 批准号:
10722294 - 财政年份:2023
- 资助金额:
$ 19.75万 - 项目类别:
Enabling synthetic biology through single cell functional genomics
通过单细胞功能基因组学实现合成生物学
- 批准号:
10556421 - 财政年份:2022
- 资助金额:
$ 19.75万 - 项目类别:
Targeting protein-protein interactions as drug targets
将蛋白质-蛋白质相互作用作为药物靶点
- 批准号:
10306398 - 财政年份:2020
- 资助金额:
$ 19.75万 - 项目类别:
Chemical Biology Interfaces at UC San Diego
加州大学圣地亚哥分校的化学生物学接口
- 批准号:
9064164 - 财政年份:2015
- 资助金额:
$ 19.75万 - 项目类别:
Chemical Biology Interfaces at UC San Diego
加州大学圣地亚哥分校的化学生物学接口
- 批准号:
8794193 - 财政年份:2015
- 资助金额:
$ 19.75万 - 项目类别:
Protein-Protein Interactions in Natural Product Biosynthesis
天然产物生物合成中的蛋白质-蛋白质相互作用
- 批准号:
10249686 - 财政年份:2012
- 资助金额:
$ 19.75万 - 项目类别:
Protein-Protein Interactions in Natural Product Biosynthesis
天然产物生物合成中的蛋白质-蛋白质相互作用
- 批准号:
10548747 - 财政年份:2012
- 资助金额:
$ 19.75万 - 项目类别:
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