Project 1: Implications of blood cell heterogeneity for CV disease

项目摘要：炎症在缺血性心血管疾病中的作用一直很好 被认可了。通常认为先天免疫系统的单核/巨噬细胞成分是 动脉粥样硬化性疾病的发生和发展的中心。其他人最近的发展已经 表明存在具有特殊功能的单核细胞亚群，我们有 开发了可以进一步评估造血细胞内异质性的系统。我们的计划是使用 允许对异质性进行克隆评估的新兴技术解决了以下问题 单核/巨噬细胞的特定亚群导致动脉粥样硬化。我们将确定单核/巨噬细胞 先天具有动脉粥样硬化形成的易感性，或在到达动脉粥样硬化后获得这种特征。 我们将定义这些功能属性的分子驱动因素，并测试靶向干预的类型 单核/巨噬细胞可降低进行性动脉粥样硬化的风险。

PROJECT SUMMARY: The contributions of inflammation to ischemic cardiovascular disease has been well recognized. It is generally thought that monocyte/macrophage components of the innate immune system are central to the initiation and progression of atherosclerotic disease. Recent developments by others have suggested that there are specialized subsets of monocytic cells with particular functions and we have developed systems that can further assess heterogeneity within hematopoietic cells. Our plan is to use the emerging technologies that permit clonal assessments of heterogeneity to address the question of what specific subsets of monocyte/macrophages drive atherosclerosis. We will determine if monocyte/macrophages are born with endowed predisposition to atherogenesis or acquire such features after arrival at an atheroma. We will define molecular drivers of such functional attributes and test types of interventions targeting monocyte/macrophages to reduce the risk of progressive atherosclerosis.