Project 1: Implications of blood cell heterogeneity for CV disease

项目 1：血细胞异质性对心血管疾病的影响

• 批准号: 10238040
• 负责人: David T Scadden
• 金额: $ 39.28万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10238040
• 关键词: Address; Affect; Age; Animals; Arterial Fatty Streak; Arteries; Atherosclerosis; Behavior; Blood; Blood Cells; CRISPR/Cas technology; Cardiac; Cardiovascular Diseases; Cells; Clonal Hematopoietic Stem Cell; Collaborations; Development; Disease; Effector Cell; Emerging Technologies; Epigenetic Process; Heart Injuries; Heart failure; Hematopoiesis; Hematopoietic; Hematopoietic System; Hematopoietic stem cells; Heterogeneity; Human; Individual; Infarction; Inflammation; Inflammatory; Injury; Innate Immune System; Instruction; Intervention; Kinetics; Label; Methods; Modification; Molecular; Mus; Mutation; Myocardial Infarction; Outcome; Phenotype; Predisposition; Process; Recovery; Risk; Role; Signal Transduction; System; Testing; Tissues; atherogenesis; base; cardiovascular disorder risk; cardiovascular risk factor; cell behavior; cell type; healing; in vivo; macrophage; member; monocyte; mouse model; premalignant; prevent; progenitor; repaired; resilience; single cell analysis; synergism; tool

PROJECT SUMMARY: The contributions of inflammation to ischemic cardiovascular disease has been well recognized. It is generally thought that monocyte/macrophage components of the innate immune system are central to the initiation and progression of atherosclerotic disease. Recent developments by others have suggested that there are specialized subsets of monocytic cells with particular functions and we have developed systems that can further assess heterogeneity within hematopoietic cells. Our plan is to use the emerging technologies that permit clonal assessments of heterogeneity to address the question of what specific subsets of monocyte/macrophages drive atherosclerosis. We will determine if monocyte/macrophages are born with endowed predisposition to atherogenesis or acquire such features after arrival at an atheroma. We will define molecular drivers of such functional attributes and test types of interventions targeting monocyte/macrophages to reduce the risk of progressive atherosclerosis.

项目摘要：炎症在缺血性心血管疾病中的作用已经得到了很好的研究