Building capacity for Implementation Science research in Non-Communicable Diseases (BImS-NCDs)

摘要 Mbarara科技大学（MUST）开发并成功实施了“Mbarara 大学研究培训倡议（MURTI）'（D43 TW 010128; PI：Obua），以建立初级教师的能力， 艾滋病毒和非传染性疾病。我们现在建议通过创建一个新的投资项目来扩大MURTI的投资。 MUST的研究培训中心，得到了美国国立卫生研究院和IC合作伙伴的支持， 国家神经疾病和中风研究所（NINDS）的使命是寻求 关于大脑和神经系统的知识，并利用这些知识来减轻神经系统的负担。 所有人的疾病;国家精神卫生研究所（NIMH）支持研究， 对精神疾病的理解和治疗;以及国家酒精滥用和酒精中毒研究所 （NIAAA）支持并开展关于酒精使用对人类健康和福祉影响的研究。 必须利用这些支助加强乌干达农村卫生专业培训机构的能力 （HPTI）在整个生命周期内对非传染性疾病的影响。非传染性疾病是一种新出现的全球大流行病，也是导致死亡的主要原因 在发展中国家，这一比例更高。必须，一个以农村为基础的机构已经发展起来 非传染性疾病的能力（例如，神经系统疾病、精神健康）和IS通过D43 TW 010128解决 解决现实问题，提供可持续的解决方案。我们建议在澳门理工大学建立一个研究培训中心， 非传染性疾病的科学研究（BImS-NCDs）”。我们将借鉴 在D43 TW 010128期间开发的现有专业知识（指导方法和/或基础设施）， 培训和指导临床医生和卫生专业人员，同时发展新的专业知识，在理论和 在乌干达，我们正在制定一个框架，以调整实施科学工具，以适应乌干达的情况。通过中心，我们将提供 领导力，最佳实践，研究支持，指导和生物医学，行为和IS培训， 为乌干达农村地区的伙伴机构提供长期培训。我们计划解决三个科学领域的公共 健康意义：神经系统疾病、心理健康和酒精使用障碍。这将是 通过四个具体目标实现：1）在澳门理工大学建立一个培训中心，以支持研究和研究 培训实施科学; 2）培训临床医生和卫生专业人员掌握基本的流行病学， 预防和实施科学技能，以便在乌干达农村的整个生命周期内开展非传染性疾病研究; 3)为生物多样性和免疫缺陷-非传染性疾病导师提供导师培训;以及 学员和导师。在5年的时间里，我们将培养6名博士生和800多名实习生的能力， 短期课程。这些目标将得到来自加州科学与医学大学的专业知识的支持 （UBM）、克莱蒙研究生大学（CGU）和马萨诸塞州总医院（MGH）以及乌干达境内。 到5年资助结束时，这笔赠款将为未来的NCD研究提供基础专业知识 培训集中在非洲农村地区。

Abstract Mbarara University of Science and Technology (MUST) developed and successfully implemented the ‘Mbarara University Research Training Initiative (MURTI)’ (D43TW010128; PI: Obua) to build capacity for junior faculty in HIV and non-communicable diseases (NCDs). We now propose to expand on the MURTI investment by creating a research training hub at MUST with support from National Institutes of Health and IC partners such as the National Institute of Neurological Disorders and Stroke (NINDS) with the mission is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease for all people; the National Institute of Mental Health (NIMH) which supports research that transforms the understanding and treatment of mental illnesses; and the National Institute on Alcohol Abuse and Alcoholism (NIAAA) that supports and conducts research on the impact of alcohol use on human health and well-being. MUST will utilize these supports to strengthen the capacity of rural Uganda health professions training institutions (HPTIs) on NCDs across the lifespan. NCDs are an emerging global pandemic and the leading cause of death with disproportionately higher rates in developing countries. MUST, a rural based institution has developed capacity in NCDs (e.g., neurological disorders, mental health) and IS through the D43TW010128 to address real-life problems and provide sustainable solutions. We propose a research training hub at MUST for “Building capacity for Implementation Science research in Non-Communicable Diseases (BImS-NCDs)”. We will draw on existing expertise (methods and/or infrastructure for mentorship) developed during the D43TW010128 to provide training and mentoring to clinicians and health professionals, while developing new expertise in IS theories and frameworks to adapt implementation science tools for the Ugandan context. Through the hub, we will provide leadership, best practices, research support, mentoring and training in biomedical, behavioral, and IS for long- term training to the partner institutions in rural Uganda. We plan to address three scientific areas of public health significance: neurological disorders, mental health, and alcohol use disorders. This will be achieved through four specific aims: 1) To create a training hub at MUST to support research and research training in implementation science; 2) To train clinicians and health professionals in basic epidemiological, prevention, and implementation science skills to conduct research in NCDs across the lifespan in rural Uganda; 3) To provide mentor training for BImS-NCDs mentors; and 4) To create a community of practice among the trainees and mentors. During the 5-years, we will build capacity of the 6 PhD trainees and over 800 trainees in short courses. The aims will be supported by expertise from the California University of Science and Medicine (CUSM), Claremont Graduate University (CGU) and Massachusetts General Hospital (MGH) and within Uganda. By the end of the 5 Years funding, this grant will have provided foundational expertise for future NCD research and training focused on rural Africa.