Building capacity for Implementation Science research in Non-Communicable Diseases (BImS-NCDs)

摘要 姆巴拉拉科技大学(MUST)开发并成功地实施了‘姆巴拉拉 大学研究培训倡议(MURTI)“(D43TW010128；PI：OBUA)，以建设#年初级教员的能力 艾滋病毒和非传染性疾病。我们现在建议通过创建以下方式来扩大Murti的投资 在国立卫生研究院和IC合作伙伴(如 美国国家神经疾病和中风研究所(NINDS)的使命是寻求根本 关于大脑和神经系统的知识，并利用这些知识来减轻神经科的负担 所有人的疾病；国家心理健康研究所(NIMH)，它支持将 对精神疾病的理解和治疗；以及国家酒精滥用和酒精中毒研究所 (NIAAA)支持并进行关于饮酒对人类健康和福祉影响的研究。 必须利用这些支助加强乌干达农村卫生专业人员培训机构的能力 (HPTIs)在非传染性疾病的整个寿命内。非传染性疾病是一种新兴的全球大流行，也是主要的死亡原因。 发展中国家的这一比例高得不成比例。必须，一个以农村为基础的机构已经发展起来 在非传染性疾病(如神经疾病、精神健康)方面的能力，并通过D43TW010128来解决 现实生活中的问题并提供可持续的解决方案。我们建议在MUSINE建立一个研究培训中心 实施非传染性疾病科学研究的能力(BIMS-NCD)“。我们将利用 在D43TW010128期间开发的现有专业知识(指导方法和/或基础设施)，以提供 培训和指导临床医生和卫生专业人员，同时开发IS理论和 调整执行科学工具以适应乌干达情况的框架。通过该枢纽，我们将提供 领导力、最佳实践、研究支持、生物医学、行为学方面的指导和培训，并且是长期的- 向乌干达农村的伙伴机构提供定期培训。我们计划针对公众的三个科学领域 健康意义：神经性疾病、精神健康和酒精使用障碍。这将是 通过四个具体目标实现：1)建立一个培训中心，支持研究和研究 实施科学培训；2)培训基础流行病学方面的临床医生和卫生专业人员， 在乌干达农村地区终身开展非传染性疾病研究的预防和实施科学技能； 3)为BIMS-NCDS导师提供导师培训；以及4)在 实习生和导师。在5年内，我们将建设6名博士生和800多名学员的能力 短期课程。这些目标将得到加州科学与医学大学的专业知识的支持 (C)、克莱蒙特研究生院(CGU)、马萨诸塞州总医院(MGH)以及乌干达境内。 到5年资助结束时，这笔资金将为未来的非传染性疾病研究提供基础性的专业知识。 培训的重点是非洲农村地区。

Abstract Mbarara University of Science and Technology (MUST) developed and successfully implemented the ‘Mbarara University Research Training Initiative (MURTI)’ (D43TW010128; PI: Obua) to build capacity for junior faculty in HIV and non-communicable diseases (NCDs). We now propose to expand on the MURTI investment by creating a research training hub at MUST with support from National Institutes of Health and IC partners such as the National Institute of Neurological Disorders and Stroke (NINDS) with the mission is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease for all people; the National Institute of Mental Health (NIMH) which supports research that transforms the understanding and treatment of mental illnesses; and the National Institute on Alcohol Abuse and Alcoholism (NIAAA) that supports and conducts research on the impact of alcohol use on human health and well-being. MUST will utilize these supports to strengthen the capacity of rural Uganda health professions training institutions (HPTIs) on NCDs across the lifespan. NCDs are an emerging global pandemic and the leading cause of death with disproportionately higher rates in developing countries. MUST, a rural based institution has developed capacity in NCDs (e.g., neurological disorders, mental health) and IS through the D43TW010128 to address real-life problems and provide sustainable solutions. We propose a research training hub at MUST for “Building capacity for Implementation Science research in Non-Communicable Diseases (BImS-NCDs)”. We will draw on existing expertise (methods and/or infrastructure for mentorship) developed during the D43TW010128 to provide training and mentoring to clinicians and health professionals, while developing new expertise in IS theories and frameworks to adapt implementation science tools for the Ugandan context. Through the hub, we will provide leadership, best practices, research support, mentoring and training in biomedical, behavioral, and IS for long- term training to the partner institutions in rural Uganda. We plan to address three scientific areas of public health significance: neurological disorders, mental health, and alcohol use disorders. This will be achieved through four specific aims: 1) To create a training hub at MUST to support research and research training in implementation science; 2) To train clinicians and health professionals in basic epidemiological, prevention, and implementation science skills to conduct research in NCDs across the lifespan in rural Uganda; 3) To provide mentor training for BImS-NCDs mentors; and 4) To create a community of practice among the trainees and mentors. During the 5-years, we will build capacity of the 6 PhD trainees and over 800 trainees in short courses. The aims will be supported by expertise from the California University of Science and Medicine (CUSM), Claremont Graduate University (CGU) and Massachusetts General Hospital (MGH) and within Uganda. By the end of the 5 Years funding, this grant will have provided foundational expertise for future NCD research and training focused on rural Africa.