Clinical Core

项目总结-临床核心 探索性范德比尔特阿尔茨海默病研究中心（VADRC）临床核心将支持当地和 国家阿尔茨海默病研究活动。在Paul纽豪斯博士的指导下， 将加强现有的机构基础设施，以吸引和招募老年人参与阿尔茨海默病， 相关的痴呆症研究机会，以支持创建一个未来的P30推广和招聘核心。 招募活动将建立在现有的4000多名成员阿尔茨海默病研究登记处和 专注于招募记忆诊所患者和社区居住的老年人感兴趣的生物标志物为重点 老年痴呆症的研究机会。将着重强调与 范德比尔特-梅哈里联盟，以推广和参与当地非裔美国人社区， 重点加强生物标志物和尸检参与。临床中心将负责建立 并每年对150名年龄在60岁及以上的特征良好的参与者进行“概念验证”， 认知未受损或符合轻度认知障碍或阿尔茨海默病的既定标准。 利用完善的协议和广泛的本地基础设施，我们将收集详细的临床， 认知、神经成像、遗传和生物样本数据。这些数据将支持我们中心的主题 强调预防目标、大规模发现和药理干预， 强调非淀粉样蛋白损伤途径通常与核心阿尔茨海默病病理学共同发生。 临床核心将参与队列参与死前脑捐赠同意，并进行可扩展的尸检 协议管道将实施，以支持未来的P30神经病理学核心与 拉什阿尔茨海默病研究中心。临床核心将支持当地和国家的研究工作 通过促进合作和分享当地和全国的数据来治疗阿尔茨海默病。数据和 生物标本将根据目前的最佳做法以统一的方式收集，并与 国家阿尔茨海默氏症协调中心，国家阿尔茨海默氏症集中储存库， 相关痴呆症，和国家研究所对老年痴呆症的遗传储存网站。的 临床核心将通过分布临床，认知，神经影像，遗传， 和生物样本数据，并最大限度地提高临床核心队列的参与率， 研究者发起的多中心研究。最后，临床核心将支持培训下一代 阿尔茨海默病临床医生和研究人员通过提供参与者，数据，生物标本，合作， 和领导机会。我们的跨学科临床核心研究人员已经证明了专业知识， 在参与者招募和保留以及复杂的协议执行方面有良好的记录。 因此，临床核心将成为VADRC在支持地方和国家 阿尔茨海默病研究活动。

PROJECT SUMMARY – CLINICAL CORE The Exploratory Vanderbilt Alzheimer’s Disease Research Center (VADRC) Clinical Core will support local and national Alzheimer’s disease research activities. Under the direction of Dr. Paul Newhouse, the Clinical Core will enhance existing institutional infrastructure to engage and recruit older adults into Alzheimer’s disease and related dementia research opportunities to support creating a future P30 Outreach and Recruitment Core. Recruitment activities will build upon the existing 4000+ member Alzheimer’s Disease Research Registry and focus on recruiting memory clinic patients and community-dwelling older adults interested in biomarker-focused Alzheimer’s disease research opportunities. A strong emphasis will be placed on partnering with the Vanderbilt-Meharry Alliance for outreach and engagement in the local African American community with a focus on enhancing biomarker and autopsy participation. The Clinical Core will be responsible for establishing and annually following a “proof of concept” cohort of 150 well-characterized participants age 60 and older who are cognitively unimpaired or meet established criteria for mild cognitive impairment or Alzheimer’s disease. Leveraging well-established protocols and extensive local infrastructure, we will collect detailed clinical, cognitive, neuroimaging, genetic, and biospecimen data. These data will support our Center’s thematic emphasis on prevention targets, large-scale discovery, and pharmacological interventions that collectively emphasize non-amyloid pathways of injury commonly co-occurring with core Alzheimer’s disease pathology. The Clinical Core will engage cohort participation in antemortem brain donation assent, and a scalable autopsy protocol pipeline will be implemented to support a future P30 Neuropathology Core in collaboration with the Rush Alzheimer’s Disease Research Center. The Clinical Core will support local and national research efforts in Alzheimer’s disease by fostering collaborations and sharing data locally and nationally. Data and biospecimens will be collected in a uniform manner according to current best-practices and shared with the National Alzheimer’s Coordinating Center, the National Centralized Repository for Alzheimer’s Disease and Related Dementias, and the National Institute on Aging Genetics of Alzheimer’s Disease Storage Site. The Clinical Core will maximize local research initiatives by distributing clinical, cognitive, neuroimaging, genetic, and biospecimen data to qualified investigators and maximizing Clinical Core cohort participation in investigator initiated and multi-site studies. Finally, the Clinical Core will support training the next generation of Alzheimer’s disease clinicians and investigators by providing participants, data, biospecimens, collaboration, and leadership opportunities. Our interdisciplinary Clinical Core investigators have demonstrated expertise and a proven track record in participant recruitment and retention as well as complex protocol implementation. Thus, the Clinical Core will be a successful focal point of the VADRC in supporting both local and national Alzheimer’s disease research activities.