Clinical Core

临床核心

• 批准号: 10470725
• 负责人: PAUL A. NEWHOUSE
• 金额: $ 105.75万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-15 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10470725
• 关键词: African American; African American population; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease related dementia; Alzheimer' s disease therapeutic; Autopsy; Biological Markers; Brain; Clinic; Clinical; Clinical Trials; Cognitive; Collaborations; Collection; Communities; Complex; Data; Data Collection; Data Set; Delirium; Development; Disease; Elderly; Enrollment; Fostering; Future; Genetic; Goals; Image; Individual; Infrastructure; Injury; Intervention; Leadership; MRI Scans; Magnetic Resonance Imaging; Memory; National Institute on Aging; Participant; Pathway interactions; Patient Recruitments; Patients; Pharmacology; Phase; Prevention; Procedures; Protocols documentation; Recruitment Activity; Registries; Research; Research Activity; Research Institute; Research Personnel; Risk; Sampling; Site; Tissues; Training; Training Support; career; clinical center; cohort; cooperative study; data resource; data sharing; genomic data; interest; member; mild cognitive impairment; neuroimaging; neuropathology; next generation; novel; outreach; participant retention; pre-clinical; preservation; programs; ranpirnase; recruit; repository; resilience; telephone-based

PROJECT SUMMARY – CLINICAL CORE The Exploratory Vanderbilt Alzheimer’s Disease Research Center (VADRC) Clinical Core will support local and national Alzheimer’s disease research activities. Under the direction of Dr. Paul Newhouse, the Clinical Core will enhance existing institutional infrastructure to engage and recruit older adults into Alzheimer’s disease and related dementia research opportunities to support creating a future P30 Outreach and Recruitment Core. Recruitment activities will build upon the existing 4000+ member Alzheimer’s Disease Research Registry and focus on recruiting memory clinic patients and community-dwelling older adults interested in biomarker-focused Alzheimer’s disease research opportunities. A strong emphasis will be placed on partnering with the Vanderbilt-Meharry Alliance for outreach and engagement in the local African American community with a focus on enhancing biomarker and autopsy participation. The Clinical Core will be responsible for establishing and annually following a “proof of concept” cohort of 150 well-characterized participants age 60 and older who are cognitively unimpaired or meet established criteria for mild cognitive impairment or Alzheimer’s disease. Leveraging well-established protocols and extensive local infrastructure, we will collect detailed clinical, cognitive, neuroimaging, genetic, and biospecimen data. These data will support our Center’s thematic emphasis on prevention targets, large-scale discovery, and pharmacological interventions that collectively emphasize non-amyloid pathways of injury commonly co-occurring with core Alzheimer’s disease pathology. The Clinical Core will engage cohort participation in antemortem brain donation assent, and a scalable autopsy protocol pipeline will be implemented to support a future P30 Neuropathology Core in collaboration with the Rush Alzheimer’s Disease Research Center. The Clinical Core will support local and national research efforts in Alzheimer’s disease by fostering collaborations and sharing data locally and nationally. Data and biospecimens will be collected in a uniform manner according to current best-practices and shared with the National Alzheimer’s Coordinating Center, the National Centralized Repository for Alzheimer’s Disease and Related Dementias, and the National Institute on Aging Genetics of Alzheimer’s Disease Storage Site. The Clinical Core will maximize local research initiatives by distributing clinical, cognitive, neuroimaging, genetic, and biospecimen data to qualified investigators and maximizing Clinical Core cohort participation in investigator initiated and multi-site studies. Finally, the Clinical Core will support training the next generation of Alzheimer’s disease clinicians and investigators by providing participants, data, biospecimens, collaboration, and leadership opportunities. Our interdisciplinary Clinical Core investigators have demonstrated expertise and a proven track record in participant recruitment and retention as well as complex protocol implementation. Thus, the Clinical Core will be a successful focal point of the VADRC in supporting both local and national Alzheimer’s disease research activities.

项目摘要-临床核心 探索性范德比尔特阿尔茨海默病研究中心(VADRC)临床核心将支持当地和 国家阿尔茨海默病研究活动。在保罗·纽豪斯博士的指导下，临床核心 将加强现有的机构基础设施，以吸引和招募老年人治疗阿尔茨海默氏症，并 与痴呆症相关的研究机会，以支持创建未来的P30外联和招募核心。 招募活动将在现有的4000多名阿尔茨海默病研究登记处和 专注于招募记忆诊所的患者和对生物标记物感兴趣的社区老年人 阿尔茨海默氏症的研究机会。重点将放在与 范德比尔特-梅哈里联盟在当地非裔美国人社区中的外联和参与 重点加强生物标记物和尸检参与度。临床核心将负责建立 每年在150名60岁及以上的具有良好特征的参与者的“概念验证”队列之后 认知未受损或符合轻度认知障碍或阿尔茨海默病的既定标准。 利用完善的协议和广泛的本地基础设施，我们将收集详细的临床、 认知、神经成像、遗传和生物谱数据。这些数据将支持我们中心的主题 强调预防目标、大规模发现和药物干预，这些共同 强调非淀粉样蛋白损伤途径，通常与阿尔茨海默病的核心病理同时发生。 临床核心将参与死前脑捐赠的队列参与，并进行可扩展的尸检 将实施协议管道，以支持未来的P30神经病理核心 拉什阿尔茨海默氏症研究中心。临床核心将支持地方和国家的研究工作 通过促进合作和共享当地和全国的数据，在阿尔茨海默氏症方面取得进展。数据和 将根据当前的最佳做法，以统一的方式收集生物检疫，并与 国家阿尔茨海默氏症协调中心，国家阿尔茨海默氏病中央资料库和 与痴呆症相关，以及阿尔茨海默病国家衰老遗传学研究所的存储站点。这个 临床核心将通过分发临床、认知、神经成像、遗传学、 和生物谱数据提供给合格的研究人员，并最大限度地增加临床核心队列的参与 由调查员发起的多点研究。最后，临床核心将支持培训下一代 阿尔茨海默病临床医生和研究人员通过提供参与者、数据、生物样品、协作、 和领导力的机会。我们的跨学科临床核心研究人员已经展示了专业知识和 在招募和留住参与者以及执行复杂的协议方面有良好的记录。 因此，临床核心中心将成为VADRC支持地方和国家的一个成功的焦点 阿尔茨海默病研究活动。