PHYSICAL ACTIVITY, TESTOSTERONE AND COGNITION IN OLDER MEN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 关于锻炼对健康的好处，人们已经说了很多。随着人口老龄化，我们尤其有兴趣研究老年人口中体力活动与认知能力(例如学习和记忆)之间的关系。目前，可以在文献中找到一些关于这种关系的研究，一些证据表明，锻炼对保护老年认知能力下降有好处。然而，这一结论仍然不清楚，因为许多研究未能表明这种关系。其他涉及老年男性的研究表明，睾丸素水平低与认知能力下降和阿尔茨海默氏症有关。 在这里，我们提出了一项研究，以收集30名年龄在65岁至85岁之间的健康男性的体力活动量、记忆力表现和睾酮水平的数据。参与者将通过在健身中心、养老院和报纸上发布广告来招募。我们的目标是招募15名高运动量的男性(定期每周至少锻炼3次)和15名低活动量的男性(每周锻炼少于2次的男性)。每个参与者的学习时间为2周。参与者将在手腕上佩戴一个小型活动监测器，并在两周内记录活动日记。在两周的时间结束时，将收集活动数据(包括测量和自我报告)。此外，在为期两周的研究结束时，他们将完成两项记忆任务，并在最后一次访问时抽血测量睾酮水平。 在这项初步研究中收集的数据将被分析，以确定老年男性的体育运动量、记忆力表现和睾丸激素水平之间是否存在关系。这项研究的结果将提供有用的研究信息，同时具有重要的公共卫生影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Much has been said about the benefits of exercise to health. With our aging population, we are particularly interested in studying the relationship between physical activity and cognitive abilities (e.g. learning and memory) in the elderly populations. Currently, a number of studies on this relationship can be found in the literature, with some evidence suggesting that exercise provides benefits in protecting cognitive decline in old age. However, this conclusion remains unclear as a number of studies failed to show this relationship. Other studies involving older men suggested that low testosterone level is related to cognitive decline and Alzheimer's disease. Here, we propose a study to collect data on the amount of physical activity, memory performance, and testosterone levels in 30 healthy men between the age of 65 to 85. Participants will be recruited through advertisement at fitness centers, senior homes, as well as in newspapers. We aim to recruit 15 men with high activity (men who regularly exercise at least 3 times a week) and 15 men with low activity (men who exercise less than 2 times a week). The study period for each participant will be 2 weeks. Participants will wear a small activity monitor on their wrist and keep an activity diary through 2 weeks. At the end of the 2-week period, activity data (both measured and self-reported) will be collected. In addition, they will complete two memory tasks and have a blood draw for testosterone level measurement at their last visit at the end of the 2-week study period. The data collected in this pilot study will be analyzed to see if there is a relationship between the amount of physical exercise, memory performance and testosterone level in older men. The outcome of this study will provide useful research information, at the same time carry important public health implications.