Core B: Omics and Bioinformatics Core MSU COBRE Phase II

项目摘要 密西西比州生物医学研究卓越中心(COBRE)第一阶段，病原体-宿主相互作用 州立大学(MSU)成功地将密歇根州立大学基因组学、生物计算和 生物技术(IGBB)作为系统生物学核心B的一部分。核心B服务提供获得专业知识的途径， 产生和分析高通量组学所需的仪器、生物计算和生物信息学 数据。OMICS和生物信息学核心B在此Cobre第二阶段应用程序中的目标是1)建立在 在科布雷第一阶段取得的技术和智力基础设施收益，以及2)继续提供服务 以有效和响应的方式提供专业知识和专业知识，以满足Cobre第二阶段主管的关键需求 调查人员。扩展密歇根州立大学的组学能力，以满足科布雷第二阶段研究员的需求 代谢组学，我们建议整合密歇根州立大学现有的仪器和资源，来自不同的 将部门和研究所(实际位置在一英里以内)转变为“虚拟的”OMIC和生物信息学核心(核心 b)。因此，核心B的目标是在现有设备和人员的基础上继续整合和建设 进入科布雷大气层不仅使科布雷调查人员更有效率，而且还 促进密歇根州立大学的生物医学研究。这将通过三个具体目标来实现：1. 提供一种管理机制，以确保Cobre调查人员能够获得仪器和专业知识 进行组学研究，如蛋白质组学、RNA-Seq和代谢组学以及生物计算和 生物信息学。2.加强现有基础设施、稳定性和可持续性所需的组学技术 科布雷项目。3.提供Cobre第二阶段调查人员所需的技术和分析支持。 组学和生物信息学核心B将为Cobre的可持续性做出重大贡献，因为它提供了 处于生物医学研究企业前沿的基因组规模技术服务。科布雷 第二阶段核心B将在第一阶段的成功基础上再接再厉，使Cobre调查人员能够制定主题 专注于多学科研究，成为一个运转良好、富有成效的生物医学研究中心。

Project Summary The Center of Biomedical Research Excellence (COBRE) Phase I, Pathogen-Host Interactions at Mississippi State University (MSU) successfully incorporated the MSU Institute for Genomics, Biocomputing and Biotechnology (IGBB) as part of a systems biology Core B. Core B services provide access to expertise, instrumentation, biocomputing and bioinformatics necessary for generating and analyzing high throughput omics data. The goals of the Omics and Bioinformatics Core B in this COBRE Phase II application are to 1) build on the technical and intellectual infrastructure gains made in COBRE Phase I, and 2) continue to provide service and expertise in an effective and responsive manner to meet the critical needs of COBRE Phase II Lead Investigators. To expand omics capabilities at MSU to meet COBRE Phase II investigator needs in metabolomics, we propose to integrate the existing instrumentation and resources at MSU from different departments and institutes (located physically within a mile) into a ‘virtual’ Omics and Bioinformatics Core (Core B). Therefore, the Objective of Core B is to continue integrating and building on existing equipment and personnel into the COBRE atmosphere not only to make access more efficient for COBRE investigators but also to stimulate biomedical research at MSU in general. This will be accomplished through three specific aims: 1. Provide an administrative mechanism to ensure COBRE investigators access to instrumentation, and expertise for conducting omics research, such as proteomics, RNA-Seq and metabolomics as well as biocomputing and bioinformatics. 2. Enhance existing infrastructure, stability, and sustainability of omics technologies required for COBRE projects. 3. Provide technologies and analytical support required by Phase II COBRE investigators. Omics and Bioinformatics Core B will make significant contribution towards COBRE sustainability as it provides services in genome scale technologies that are at the forefront of the biomedical research enterprise. COBRE Phase II Core B will build on the success in of Phase I and enable COBRE Investigators to develop the thematic multidisciplinary research focus into a functioning, productive biomedical research center.