Core B: Omics and Bioinformatics Core MSU COBRE Phase II

项目摘要 密西西比生物医学研究卓越中心（COBRE）第一阶段，病原体-宿主相互作用 州立大学（MSU）成功地将MSU基因组学、生物计算和 生物技术（IGBB）作为系统生物学核心B的一部分。核心B服务提供专业知识， 生成和分析高通量组学所必需的仪器、生物计算和生物信息学 数据COBRE第二阶段应用中组学和生物信息学核心B的目标是：1）建立在 COBRE第一阶段所取得的技术和知识基础设施方面的进展; 2）继续提供服务 以有效和快速的方式满足COBRE第二阶段领导的关键需求 Investigators.为了扩大MSU的组学能力，以满足COBRE第二阶段研究者的需求， 代谢组学，我们建议整合现有的仪器和资源在密歇根州立大学从不同的 部门和研究所（物理上位于一英里内）到一个“虚拟”组学和生物信息学核心（核心 B）。因此，核心B的目标是在现有设备和人员的基础上继续整合和建设 进入COBRE大气层，不仅使COBRE调查人员更有效地进入， 促进MSU生物医学研究。这将通过三个具体目标来实现：1. 提供行政机制，确保COBRE调查人员能够使用仪器和专业知识 进行组学研究，如蛋白质组学，RNA-Seq和代谢组学以及生物计算， 生物信息学2.增强现有基础设施、稳定性和所需组学技术的可持续性 COBRE项目。3.提供COBRE第二阶段研究人员所需的技术和分析支持。 组学和生物信息学核心B将为COBRE的可持续性做出重大贡献，因为它提供了 在基因组规模的技术服务，是在生物医学研究企业的前沿。Cobre 第二阶段核心B将建立在第一阶段的成功基础上，使COBRE调查人员能够开发主题 多学科的研究重点，成为一个功能，生产生物医学研究中心。

Project Summary The Center of Biomedical Research Excellence (COBRE) Phase I, Pathogen-Host Interactions at Mississippi State University (MSU) successfully incorporated the MSU Institute for Genomics, Biocomputing and Biotechnology (IGBB) as part of a systems biology Core B. Core B services provide access to expertise, instrumentation, biocomputing and bioinformatics necessary for generating and analyzing high throughput omics data. The goals of the Omics and Bioinformatics Core B in this COBRE Phase II application are to 1) build on the technical and intellectual infrastructure gains made in COBRE Phase I, and 2) continue to provide service and expertise in an effective and responsive manner to meet the critical needs of COBRE Phase II Lead Investigators. To expand omics capabilities at MSU to meet COBRE Phase II investigator needs in metabolomics, we propose to integrate the existing instrumentation and resources at MSU from different departments and institutes (located physically within a mile) into a ‘virtual’ Omics and Bioinformatics Core (Core B). Therefore, the Objective of Core B is to continue integrating and building on existing equipment and personnel into the COBRE atmosphere not only to make access more efficient for COBRE investigators but also to stimulate biomedical research at MSU in general. This will be accomplished through three specific aims: 1. Provide an administrative mechanism to ensure COBRE investigators access to instrumentation, and expertise for conducting omics research, such as proteomics, RNA-Seq and metabolomics as well as biocomputing and bioinformatics. 2. Enhance existing infrastructure, stability, and sustainability of omics technologies required for COBRE projects. 3. Provide technologies and analytical support required by Phase II COBRE investigators. Omics and Bioinformatics Core B will make significant contribution towards COBRE sustainability as it provides services in genome scale technologies that are at the forefront of the biomedical research enterprise. COBRE Phase II Core B will build on the success in of Phase I and enable COBRE Investigators to develop the thematic multidisciplinary research focus into a functioning, productive biomedical research center.