Core B: Omics and Bioinformatics Core MSU COBRE Phase II

核心 B：组学和生物信息学核心 MSU COBRE II 期

• 批准号: 10004091
• 负责人: Bindu Nanduri
• 金额: $ 20万
• 依托单位: MISSISSIPPI STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10004091
• 关键词: Address; Adoption; Atmosphere; Bioinformatics; Biological; Biomedical Research; Biotechnology; Centers of Research Excellence; Communities; Data; Data Analyses; Educational process of instructing; Ensure; Equipment; Funding; Genomics; Goals; Human Resources; Individual; Infectious Diseases Research; Infrastructure; Institutes; Interdisciplinary Study; Lead; Mass Spectrum Analysis; Metabolism; Mississippi; Modeling; Phase; Pilot Projects; Proteomics; Research; Research Personnel; Research Project Grants; Resources; Services; Systems Biology; Techniques; Technology; United States National Institutes of Health; Universities; University resources; Virulence; Work; base; biocomputing; bioinformatics resource; experience; experimental study; genome-wide; high throughput analysis; insight; instrument; instrumentation; metabolomics; novel; pathogen; programs; success; transcriptome sequencing; virtual

Project Summary The Center of Biomedical Research Excellence (COBRE) Phase I, Pathogen-Host Interactions at Mississippi State University (MSU) successfully incorporated the MSU Institute for Genomics, Biocomputing and Biotechnology (IGBB) as part of a systems biology Core B. Core B services provide access to expertise, instrumentation, biocomputing and bioinformatics necessary for generating and analyzing high throughput omics data. The goals of the Omics and Bioinformatics Core B in this COBRE Phase II application are to 1) build on the technical and intellectual infrastructure gains made in COBRE Phase I, and 2) continue to provide service and expertise in an effective and responsive manner to meet the critical needs of COBRE Phase II Lead Investigators. To expand omics capabilities at MSU to meet COBRE Phase II investigator needs in metabolomics, we propose to integrate the existing instrumentation and resources at MSU from different departments and institutes (located physically within a mile) into a ‘virtual’ Omics and Bioinformatics Core (Core B). Therefore, the Objective of Core B is to continue integrating and building on existing equipment and personnel into the COBRE atmosphere not only to make access more efficient for COBRE investigators but also to stimulate biomedical research at MSU in general. This will be accomplished through three specific aims: 1. Provide an administrative mechanism to ensure COBRE investigators access to instrumentation, and expertise for conducting omics research, such as proteomics, RNA-Seq and metabolomics as well as biocomputing and bioinformatics. 2. Enhance existing infrastructure, stability, and sustainability of omics technologies required for COBRE projects. 3. Provide technologies and analytical support required by Phase II COBRE investigators. Omics and Bioinformatics Core B will make significant contribution towards COBRE sustainability as it provides services in genome scale technologies that are at the forefront of the biomedical research enterprise. COBRE Phase II Core B will build on the success in of Phase I and enable COBRE Investigators to develop the thematic multidisciplinary research focus into a functioning, productive biomedical research center.

项目概要 密西西比州生物医学卓越研究中心 (COBRE) 第一阶段病原体-宿主相互作用 州立大学 (MSU) 成功合并了密歇根州立大学基因组学、生物计算和 生物技术 (IGBB) 作为系统生物学核心 B 的一部分。核心 B 服务提供获得专业知识、 生成和分析高通量组学所需的仪器、生物计算和生物信息学 数据。 COBRE II 期应用中组学和生物信息学核心 B 的目标是 1) 构建 COBRE 第一阶段取得的技术和知识基础设施收益，以及 2) 继续提供服务 和专业知识以有效和响应的方式满足 COBRE 二期牵头者的关键需​​求 调查人员。扩大 MSU 的组学能力，以满足 COBRE II 期研究人员的需求 代谢组学，我们建议整合 MSU 不同领域的现有仪器和资源 将部门和研究所（实际位于一英里之内）整合到“虚拟”组学和生物信息学核心（Core B）。因此，核心B的目标是继续整合和构建现有的设备和人员 进入 COBRE 大气不仅可以使 COBRE 调查人员更有效地进入，而且还可以 总体上促进密歇根州立大学的生物医学研究。这将通过三个具体目标来实现：1. 提供管理机制，确保 COBRE 调查人员能够使用仪器和专业知识 用于进行组学研究，例如蛋白质组学、RNA-Seq 和代谢组学以及生物计算和 生物信息学。 2. 增强组学技术所需的现有基础设施、稳定性和可持续性 COBRE 项目。 3. 提供二期COBRE研究者所需的技术和分析支持。 组学和生物信息学核心 B 将为 COBRE 的可持续发展做出重大贡献，因为它提供了 处于生物医学研究企业前沿的基因组规模技术服务。科布雷 第二阶段核心 B 将建立在第一阶段成功的基础上，并使 COBRE 研究人员能够开发主题 多学科研究重点成为一个运作良好、富有成效的生物医学研究中心。