Biospecimen Procurement and Translational Pathology Shared Resource Facility
生物样本采购和转化病理学共享资源设施
基本信息
- 批准号:10470103
- 负责人:
- 金额:$ 14.05万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-07-08 至 2023-06-30
- 项目状态:已结题
- 来源:
- 关键词:Ambulatory Care FacilitiesAnimalsAppalachian RegionAreaAwardBackBasic ScienceBioinformaticsBiological AssayBiological MarkersBiological ModelsBiometryBloodCancer CenterCancer Center Support GrantClinicalClinical Cancer CenterClinical DataClinical ResearchClinical SciencesClinical TrialsCollaborationsCollectionCommunitiesComprehensive Cancer CenterComputer softwareConsentConsultationsCustomDNADataDatabasesDepartment chairDevelopmentEducationEnsureEvaluationFacultyFamiliarityFormalinFosteringFreezingFresh TissueFundingFutureGeneticGenetic MarkersGenomicsGoalsGrowthGuidelinesHistologicHistologyHistopathologyHospitalsHumanImmunohistochemistryIn SituIn Situ HybridizationInformaticsInstitutional Review BoardsKentuckyLaboratoriesLaboratory ResearchLasersLeadershipLiquid substanceMalignant NeoplasmsMedicineMetabolicMicroscopyMissionModelingNCI Center for Cancer ResearchNamesObesity associated cancerOperative Surgical ProceduresOrganoidsOutcomeParaffin EmbeddingPathologicPathologistPathologyPatient CarePatientsPeer ReviewPlayPopulationProceduresProtocols documentationRNAResearchResearch DesignResearch PersonnelResearch TrainingResistanceResource SharingResourcesRetrospective StudiesRoleSEER ProgramSamplingScienceScientistServicesSiteSliceSpecimenStandardizationStudentsTherapeutic Clinical TrialTherapeutic Human ExperimentationTimeTissue BanksTissue EmbeddingTissue MicroarrayTissuesTrainingTraining and EducationTranslatingTranslational ResearchTumor TissueUnited States Office of Research IntegrityUniversitiesWorkanticancer researchbiological specimen archivesbiomarker evaluationcancer health disparitycancer immunotherapyclinical centerclinical investigationcohortconsent capacitydigital imagingdirect patient carefaculty supporthistological stainshuman tissueimaging systeminnovationinterestinvestigator-initiated trialmembermetabolomicsmolecular pathologyneoplasm registrynext generationnoveloperationpatient derived xenograft modelpatient populationpatient privacypopulation basedprecision medicine clinical trialspreservationprofessorprogramsprospectiverepositoryresponsesample collectiontissue biomarkerstumortumor immunologytumor metabolism
项目摘要
PROJECT SUMMARY/ABSTRACT
The Biospecimen Procurement and Translational Pathology Shared Resource Facility (BPTP SRF) is a
Markey Cancer Center (MCC)-managed resource. It facilitates the use of well-annotated human and animal
specimens and provides a wide range of translational pathology technical services in support of MCC clinical,
translational, population-based and basic science research. Over the award period, the BPTP SRF has
increased annual biospecimen dispensation from 1,738 in FY12 to 4,446 in FY17 (156% increase), increased
the total number of MCC users by 23% (48 in FY17, up from 39 in FY12) including 38 peer-reviewed funded
MCC users in FY17 (49% of all BPTP users) and expanded its range of services. New services include:
targeted and time sensitive collections, such as intra-operative, rapid fresh tissue collections supporting work in
cancer metabolism; the development of novel model systems (e.g., Warburg tissue slices for metabolic
analysis, patient-derived xenograft, organoids); review of all clinical trials, including investigator-initiated trials,
to identify specimen collection needs and develop collection protocols; fresh tissue collections and rapid blood
processing for clinical trials, resulting in support for 40 clinical trials over the funding period. The addition of a
research histology laboratory, operated per clinical guidelines, allows for an increased capacity for technical
services, such as histology, immunohistochemistry, molecular pathology, laser capture microscopy and
DNA/RNA extraction. BPTP SRF has increased its consent capacity through the cross training of all BPTP
SRF staff, as well as by using a universal opt-in consent for repository collections. BPTP SRF's name change
reflects its increased focus on translational pathology, facilitated by the support of faculty in the University of
Kentucky (UK) Department of Pathology who assist BPTP SRF staff in the development and interpretation of
novel assays, on-site evaluation of specimen content and quality for fresh tissue dispense and identification of
retrospective study and tissue microarray cohorts from surgical archive specimens dating back to 1995. This
partnership, strengthened by BPTP's leadership—C. Darrell Jennings, MD, chair of the Department of
Pathology and Laboratory Medicine, with Associate Director Qiuying Shi, MD, Assistant Professor in
Pathology—ensures MCC investigators have a clear path to the specimen resources and pathologic services
essential to their work. The BPTP SRF has streamlined operations by transitioning to the OnCore database
and adding a manager to oversee daily operations, leveraging existing resources within the MCC, including the
Clinical Research Office, the Surveillance, Epidemiology and End Results Kentucky Cancer Registry and
Cancer Research Informatics and Biostatistics and Bioinformatics SRFs, as well as non-MCC entities, such as
the Department of Pathology and Laboratory Medicine, UK Office of Research Integrity and the Center for
Clinical and Translational Science.
项目总结/摘要
生物标本采购和转化病理学共享资源设施(BPTP SRF)是一个
Markey癌症中心(MCC)-管理资源。它便于使用注释良好的人类和动物
标本,并提供广泛的转化病理学技术服务,以支持MCC的临床,
转化的、基于人口的和基础的科学研究。在授标期间,BPTP SRF已
将年度生物标本分配从2012财年的1,738份增加到2017财年的4,446份(增加156%),
MCC用户总数增加23%(2017财年为48个,2012财年为39个),包括38个同行评审资助的
MCC在2017财年的用户(所有BPTP用户的49%),并扩大了其服务范围。新服务包括:
有针对性的和时间敏感的收集,如术中快速新鲜组织收集,
癌症代谢;新模型系统的开发(例如,瓦尔堡组织切片用于代谢
分析,患者来源的异种移植物,类器官);审查所有临床试验,包括促凝剂启动的试验,
确定标本采集需求并制定采集方案;新鲜组织采集和快速采血
临床试验的处理,从而在供资期间支持了40项临床试验。的添加
组织学研究实验室,按照临床指南运作,允许增加技术能力,
服务,如组织学,免疫组织化学,分子病理学,激光捕获显微镜和
DNA/RNA提取。BPTP SRF通过对所有BPTP进行交叉培训,
SRF的工作人员,以及通过使用一个普遍的选择同意储存库收集。BPTP SRF更名
反映了其对转化病理学的日益重视,在大学教师的支持下,
肯塔基州(英国)病理学系,协助BPTP SRF工作人员制定和解释
新的检测方法,现场评估新鲜组织分配的样本含量和质量,
回顾性研究和组织微阵列队列从外科档案标本追溯到1995年。这
伙伴关系,由BPTP的领导加强-C。达雷尔詹宁斯,医学博士,系主任
病理学和实验室医学,副主任Qiuying Shi,医学博士,助理教授,
病理学-确保MCC研究人员有一个明确的路径,以标本资源和病理服务
对他们的工作至关重要。BPTP SRF通过过渡到OnCore数据库简化了操作
并增加一名经理监督日常运作,充分利用MCC内的现有资源,包括
临床研究办公室,监测,流行病学和最终结果肯塔基州癌症登记处和
癌症研究信息学和生物统计学和生物信息学SRF,以及非MCC实体,如
病理学和实验室医学系,英国研究诚信办公室和
临床和转化科学。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Therese Jeanne Bocklage其他文献
Therese Jeanne Bocklage的其他文献
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{{ truncateString('Therese Jeanne Bocklage', 18)}}的其他基金
Biospecimen Procurement and Translational Pathology Shared Resource Facility
生物样本采购和转化病理学共享资源设施
- 批准号:
10204884 - 财政年份:2013
- 资助金额:
$ 14.05万 - 项目类别:
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