Biospecimen Procurement and Translational Pathology Shared Resource Facility

项目摘要/摘要 生物检疫采购和翻译病理学共享资源基金(BPTP SRF)是一个 Markey癌症中心(MCC)-托管资源。它便于使用经过良好注释的人和动物 并提供广泛的翻译病理学技术服务，以支持MCC临床， 翻译、以人口为基础和基础科学研究。在获奖期内，BPTP SRF 年生物量分配从2012财年的1,738份增加到17财年的4,446份(增加了156%) MCC用户总数增加了23%(2017财年为48人，2012财年为39人)，其中包括38个同行评审资金 MCC用户在2017财年(占所有BPTP用户的49%)，并扩大了其服务范围。新服务包括： 有针对性和对时间敏感的收集，如术中快速新鲜组织收集，以支持 癌症新陈代谢；新模型系统的开发(例如，用于新陈代谢的Warburg组织切片 分析，患者来源的异种移植，有机物)；审查所有临床试验，包括研究人员发起的试验， 确定样本采集需求并制定采集规程；新鲜组织采集和快速血液采集 处理临床试验，从而在供资期间支助40项临床试验。增加了一个 研究组织学实验室，根据临床指南运行，允许增加技术能力 服务，如组织学、免疫组织化学、分子病理学、激光捕获显微镜和 DNA/RNA提取。BPTP SRF通过所有BPTP的交叉培训提高了其同意能力 SRF工作人员，以及对储存库收藏使用普遍的选择加入同意。BPTP SRF更名 反映了它对翻译病理学的更多关注，得到了加州大学教职员工的支持 肯塔基州(英国)病理科，协助BPTP SRF工作人员制定和解释 新鲜组织分配和鉴定的新方法、样品含量和质量的现场评估 追溯到1995年的手术档案样本的回溯性研究和组织微阵列队列。这 伙伴关系，由BPTP的领导加强-C.Darrell Jennings医学博士，卫生部主席 病理与检验医学，副主任，医学博士，助理教授 病理学-确保MCC调查人员有一条通向标本资源和病理服务的清晰途径 对他们的工作至关重要。BPTP SRF通过过渡到OnCore数据库简化了操作 以及增加一名经理来监督日常运营，利用MCC内的现有资源，包括 临床研究办公室，肯塔基州癌症登记和监测，流行病学和最终结果 癌症研究信息学和生物统计学和生物信息学SRF，以及非MCC实体，如 病理和检验医学部，英国研究诚信办公室和 临床与转化学。

PROJECT SUMMARY/ABSTRACT The Biospecimen Procurement and Translational Pathology Shared Resource Facility (BPTP SRF) is a Markey Cancer Center (MCC)-managed resource. It facilitates the use of well-annotated human and animal specimens and provides a wide range of translational pathology technical services in support of MCC clinical, translational, population-based and basic science research. Over the award period, the BPTP SRF has increased annual biospecimen dispensation from 1,738 in FY12 to 4,446 in FY17 (156% increase), increased the total number of MCC users by 23% (48 in FY17, up from 39 in FY12) including 38 peer-reviewed funded MCC users in FY17 (49% of all BPTP users) and expanded its range of services. New services include: targeted and time sensitive collections, such as intra-operative, rapid fresh tissue collections supporting work in cancer metabolism; the development of novel model systems (e.g., Warburg tissue slices for metabolic analysis, patient-derived xenograft, organoids); review of all clinical trials, including investigator-initiated trials, to identify specimen collection needs and develop collection protocols; fresh tissue collections and rapid blood processing for clinical trials, resulting in support for 40 clinical trials over the funding period. The addition of a research histology laboratory, operated per clinical guidelines, allows for an increased capacity for technical services, such as histology, immunohistochemistry, molecular pathology, laser capture microscopy and DNA/RNA extraction. BPTP SRF has increased its consent capacity through the cross training of all BPTP SRF staff, as well as by using a universal opt-in consent for repository collections. BPTP SRF's name change reflects its increased focus on translational pathology, facilitated by the support of faculty in the University of Kentucky (UK) Department of Pathology who assist BPTP SRF staff in the development and interpretation of novel assays, on-site evaluation of specimen content and quality for fresh tissue dispense and identification of retrospective study and tissue microarray cohorts from surgical archive specimens dating back to 1995. This partnership, strengthened by BPTP's leadership—C. Darrell Jennings, MD, chair of the Department of Pathology and Laboratory Medicine, with Associate Director Qiuying Shi, MD, Assistant Professor in Pathology—ensures MCC investigators have a clear path to the specimen resources and pathologic services essential to their work. The BPTP SRF has streamlined operations by transitioning to the OnCore database and adding a manager to oversee daily operations, leveraging existing resources within the MCC, including the Clinical Research Office, the Surveillance, Epidemiology and End Results Kentucky Cancer Registry and Cancer Research Informatics and Biostatistics and Bioinformatics SRFs, as well as non-MCC entities, such as the Department of Pathology and Laboratory Medicine, UK Office of Research Integrity and the Center for Clinical and Translational Science.