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Human Tissue Repository Shared Resource

人体组织库共享资源

基本信息

批准号：
8723077
负责人：
Therese Jeanne Bocklage
金额：
$ 6.52万
依托单位：
UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8723077
关键词：
American Applications Grants Archives Aspirate substance Blood specimen Bone Marrow Cancer Center Cataloging Catalogs Client satisfaction Clinical Clinical Data Collection Conflict (Psychology)Core Facility Cryoultramicrotomy Cytology Cytopathology DNA Data Diagnosis Environment Equilibrium Ethics Fellowship Focus Groups Formalin Freezing Funding Future Generations Genomics Goals Health Sciences Hematoxylin and Eosin Staining Method Histology Human Human Resources Immunohistochemistry Individual Institutional Review Boards Laboratories Lasers Link Location Microscopy New Mexico Normal tissue morphology Operative Surgical Procedures Paraffin Paraffin Embedding Pathologist Pathology Patient Rights Patients Peer Review Physician Executives Positioning Attribute Preparation Process Proteins Proteomics Protocols documentation Publications Quality Control RNA Recovery Regulation Reporting Research Research Personnel Research Support Residencies Resource Sharing Resources Retrieval Safety Sampling Serum Services Site Slide Societies Solid Solid Neoplasm Southwest Oncology Group Specimen Staining method Stains Surgical Pathology Surveys Techniques Therapeutic Tissue Banking Tissue Banks Tissue Microarray Tissue Sample Tissues Training Tumor Tissue Universities Whole Blood abstracting anticancer research base breast cancer registry cancer research center director cancer therapy college cost data mining experience human tissue medical schools medical specialties member operation outcome forecast patient privacy posters professor programs quality assurance repository tissue fixing tissue processing treatment center tumor virtual web site

项目摘要

OVERVIEW: The University of New Mexico Human Tissue Repository (HTR) is a shared central resource that provides tissue collection, processing, refinement and distribution of paraffin-embedded tissues, frozen tissues, and selected serum and bone marrow samples. It also serves as a central site for coordination of tissue banking activities for "satellite" tissue banks. These satellite banks include UNM-based specialty tissue banks and large cooperative group-focused tissue banks that are located at UNM. Ancillary services include clinical data mining, retrieval and return of surgical pathology archived paraffin-embedded formalin fixed tissue blocks, cryosectioning, paraffin sectioning, tissue processing and, since the last grant application, laser capture microscopy, tissue microarray block preparation, virtual slide generation and immunohistochemical staining. The Resource Director, Therese Bocklage MD, is a Professor in the UNM School of Medicine, Department of Pathology with 18 years of experience in Surgical and Cytopathology, including Laboratory Director of Cytopathology for four years. College of American Pathologists Laboratory Inspector, and 11 years experience in other administrative positions (Residency Program Director for the Department of Pathology, and Cytopathology Fellowship Director). As an annually approved IRB reviewed facility, the Resource collects human tumor and normal tissue in a manner that preserves the tissue for future research, especially genomics and proteomics, for diagnosis, prognosis and therapeutics following NCI Best Practices for Biospecimen Resources, issued in 2007. Whole blood and serum samples are also collected (via satellites) and stored in the core facility. In compliance with NCI Best Practices for Biospecimen Resources, 2007, the HTR conducts a systematic quality assurance and quality control program. The Resource collects tissue in a manner that protects the patient's rights and privacy yet provides the greatest possible longitudinal clinical information, maximizing the value of the tissue and balancing the sometimes inherent ethical conflicts between the needs of the patient and the researchers. The Resource reports to the Cancer Center Director, the Chair of Pathology and the Health Science Center Associate Dean for Research via the Human Tissue Oversight Committee. HTR goals include 1) accruing 10,000 high quality specimens by 2012, 2) increasing distribution by 30% yearly, and 3) achieving 25% cost recovery by 2012.

概述：新墨西哥大学人类组织库（HTR）是一个共享的中心资源，提供组织收集、处理、精炼和分发石蜡包埋组织、冷冻组织以及选定的血清和骨髓样本。它还作为协调“卫星”组织库组织库活动的中心站点。这些卫星组织库包括基于新墨西哥大学的专业组织库和位于新墨西哥大学的大型合作团体组织库。辅助服务包括临床数据挖掘，检索和返回手术病理存档石蜡包埋福尔马林