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Human Tissue Repository Shared Resource

人体组织库共享资源

基本信息

批准号：
8723111
负责人：
Therese Jeanne Bocklage
金额：
$ 0.63万
依托单位：
UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8723111
关键词：
American Applications Grants Archives Aspirate substance Blood specimen Bone Marrow Cancer Center Cataloging Catalogs Client satisfaction Clinical Clinical Data Collection Conflict (Psychology)Core Facility Cryoultramicrotomy Cytology Cytopathology DNA Data Diagnosis Environment Equilibrium Ethics Fellowship Focus Groups Formalin Freezing Funding Future Generations Genomics Goals Health Sciences Hematoxylin and Eosin Staining Method Histology Human Human Resources Immunohistochemistry Individual Institutional Review Boards Laboratories Lasers Link Location Microscopy New Mexico Normal tissue morphology Operative Surgical Procedures Paraffin Paraffin Embedding Pathologist Pathology Patient Rights Patients Peer Review Physician Executives Positioning Attribute Preparation Process Proteins Proteomics Protocols documentation Publications Quality Control RNA Recovery Regulation Reporting Research Research Personnel Research Support Residencies Resource Sharing Resources Retrieval Safety Sampling Serum Services Site Slide Societies Solid Solid Neoplasm Southwest Oncology Group Specimen Staining method Stains Surgical Pathology Surveys Techniques Therapeutic Tissue Banking Tissue Banks Tissue Microarray Tissue Sample Tissues Training Tumor Tissue Universities Whole Blood abstracting anticancer research base breast cancer registry cancer research center director cancer therapy college cost data mining experience human tissue medical schools medical specialties member operation outcome forecast patient privacy posters professor programs quality assurance repository tissue fixing tissue processing treatment center tumor virtual web site

项目摘要

OVERVIEW: The University of New Mexico Human Tissue Repository (HTR) is a shared central resource that provides tissue collection, processing, refinement and distribution of paraffin-embedded tissues, frozen tissues, and selected serum and bone marrow samples. It also serves as a central site for coordination of tissue banking activities for "satellite" tissue banks. These satellite banks include UNM-based specialty tissue banks and large cooperative group-focused tissue banks that are located at UNM. Ancillary services include clinical data mining, retrieval and return of surgical pathology archived paraffin-embedded formalin fixed tissue blocks, cryosectioning, paraffin sectioning, tissue processing and, since the last grant application, laser capture microscopy, tissue microarray block preparation, virtual slide generation and immunohistochemical staining. The Resource Director, Therese Bocklage MD, is a Professor in the UNM School of Medicine, Department of Pathology with 18 years of experience in Surgical and Cytopathology, including Laboratory Director of Cytopathology for four years. College of American Pathologists Laboratory Inspector, and 11 years experience in other administrative positions (Residency Program Director for the Department of Pathology, and Cytopathology Fellowship Director). As an annually approved IRB reviewed facility, the Resource collects human tumor and normal tissue in a manner that preserves the tissue for future research, especially genomics and proteomics, for diagnosis, prognosis and therapeutics following NCI Best Practices for Biospecimen Resources, issued in 2007. Whole blood and serum samples are also collected (via satellites) and stored in the core facility. In compliance with NCI Best Practices for Biospecimen Resources, 2007, the HTR conducts a systematic quality assurance and quality control program. The Resource collects tissue in a manner that protects the patient's rights and privacy yet provides the greatest possible longitudinal clinical information, maximizing the value of the tissue and balancing the sometimes inherent ethical conflicts between the needs of the patient and the researchers. The Resource reports to the Cancer Center Director, the Chair of Pathology and the Health Science Center Associate Dean for Research via the Human Tissue Oversight Committee. HTR goals include 1) accruing 10,000 high quality specimens by 2012, 2) increasing distribution by 30% yearly, and 3) achieving 25% cost recovery by 2012.

概述：新墨西哥大学人类组织资料库(HTR)是一个共享的中央资源，提供石蜡包埋组织、冰冻组织以及选定的血清和骨髓样本的组织收集、处理、提炼和分发。它也是协调“卫星”组织银行的组织银行活动的中心。这些卫星组织包括设在联合国大学的专门组织库和设在联合国大学的以合作团体为重点的大型组织库。辅助服务包括临床数据挖掘、手术病理存档石蜡包埋福尔马林的检索和返回固定组织块、冷冻切片、石蜡切片、组织处理，以及自上次赠款申请以来的激光捕获显微镜、组织微阵列块制备、虚拟载玻片生成和免疫组织化学染色。资源主任Therese Bocklage MD是UNM医学院病理学系的教授，在外科和细胞病理学方面有18年的经验，其中包括4年的细胞病理学实验室主任。美国病理学家学院实验室检查员，有11年其他行政职位的工作经验(病理学系住院医师计划主任和细胞病理学协会主任)。作为IRB每年批准的设施，该资源收集人类肿瘤和正常组织的方式，以保存组织用于未来的研究，特别是基因组学和蛋白质组学，用于诊断、预后和治疗，遵循2007年发布的NCI生物医学资源最佳实践。全血和血清样本也被收集(通过卫星)并存储在核心设施中。根据NCI 2007年生物质学资源最佳实践，HTR进行了系统的质量保证和质量控制计划。该资源以一种保护患者权利和隐私的方式收集组织，同时提供尽可能多的纵向临床信息，最大化组织的价值，并平衡患者和研究人员的需求之间有时固有的伦理冲突。该资源通过人体组织监督委员会向癌症中心主任、病理学主席和健康科学中心副院长研究报告。HTR的目标包括1)到2012年收集10,000个高质量的标本，2)每年增加30%的分发，以及3)到2012年实现25%的成本回收。