Developmental Exposure Alcohol Research Center

发展性暴露酒精研究中心(DEARC)是一个成功的、快速发展的 酒精研究中心，自2009年以来一直由NIAAA资助。引弧是一种综合性的， 位于宾厄姆顿大学的多学科中心，是宾厄姆顿大学 纽约州立大学(SUNY)系统。DARC的独特之处在于它专注于基础研究 检查长期酒精暴露的功能影响和神经后果 中枢神经系统发育时期--特别重要的问题 越来越多的人认识到，酗酒是一种有着强大发展根源的疾病。穿过 使用具有广泛跨学科专业知识和经验的综合研究团队， DeArc的独特定位是将其研究重点放在确定相互作用上 在神经发育过程和酒精之间，特别关注两个关键点 当未成熟的神经系统特别可能暴露在酒精中时的发育： 通过母亲饮酒在产前和青春期，当许多年轻人第一次 开始饮酒。DARC将包括四个主要的研究部分，这些部分使用已建立的 啮齿动物模型和细胞、分子、基因组、神经解剖学、生理学和 探索发育性接触的功能和神经后果的行为研究 酒精。项目还包括强调 性特有的神经行为过程，如社交环境和焦虑，促进酒精 消费 在青春期。试点项目将由一个试点项目核心进行审查和支持，旨在 进一步加强去弧度，同时鼓励发展新的酒精研究人员。批判性 由Thea行为资源、分析和集成部门为所有项目提供支持 神经科学(大脑)核心，支持和整合基因组、分子和 神经解剖学专业知识。提供科学工作的管理、监督和协调 由管理核心执行。这些项目最重要的主题是 酒精对神经系统的发育会改变神经发育并影响以后的反应 以加剧正常的饮酒倾向的方式在 青春期，从而增加了成年后饮酒和滥用酒精的可能性。

The Developmental Exposure Alcohol Research Center (DEARC) is a successful, rapidly evolving alcohol research center that has been funded by NIAAA since 2009. The DEARC is an integrative, multidisciplinary center located at Binghamton University, one of four University Centers within the State University of New York (SUNY) system. The DEARC is unique in its focus on basic research to examine functional effects and neural consequences of ethanol exposure throughout extended periods of central nervous system development - inquiries that are of particular importance given the increasing recognition that alcoholism is a disorder with strong roots in development. Through the use of integrative research teams with broad interdisciplinary expertise and experience, the DEARC is distinctively positioned to focus its research efforts on determining the interactions between neurodevelopmental processes and alcohol, with a particular focus on two key points in development when the immature nervous system is particularly likely to be exposed to alcohol: prenatally through maternal alcohol consumption and during adolescence, when many youth first initiate alcohol use. The DEARC will include four Main research components that use established rodent models and integrative cellular, molecular, genomic, neuroanatomical, physiological and behavioral studies to explore functional and neural consequences of developmental exposures to alcohol. Projects also include an emphasis on sex-specific neurobehavioral processes, such as social context and anxiety, that promote alcohol consumption during adolescence. Pilot projects will be vetted and supported by a Pilot Project Core designed to further strengthen the DEARC while encouraging the development of new alcohol researchers. Critical support for all projects is provided by thea Behavioral Resources, Analysis and Integative Neuroscience (BRAIN) Core to support and integrate projects with genomic, molecular, and neuroanatomical expertise. Management, oversight and coordination of scientific effort is provided by an Administrative Core. The over-arching theme for these projects is that exposure of the developing nervous system to alcohol alters neural development and influences later responsiveness to alcohol in ways that exacerbate the normal propensity for enhanced alcohol use during adolescence, thereby increasing the probability of alcohol use and abuse in adulthood.