Developmental Exposure Alcohol Research Center

发育暴露酒精研究中心

• 批准号: 10006492
• 负责人: Terrence Deak
• 金额: $ 157.43万
• 依托单位: STATE UNIVERSITY OF NY,BINGHAMTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10006492
• 关键词: Adolescence; Adolescent; Adult; Affective; Alcohol abuse; Alcohol consumption; Alcoholism; Alcohols; Area; Attention; Basic Science; Behavioral; Biological; Collaborations; Consumption; Decision Making; Development; Disease; Environment; Ethanol; Fetal Alcohol Exposure; Fostering; Funding; Genomics; Goals; Grant; Growth; Heavy Drinking; Infrastructure; Institution; Knowledge; Laboratories; Life; Mentors; Molecular; National Institute on Alcohol Abuse and Alcoholism; Nervous system structure; Neuraxis; Neurosciences; New York; Physiological; Pilot Projects; Plant Roots; Positioning Attribute; Postdoctoral Fellow; Pregnancy; Probability; Process; Request for Applications; Research; Research Design; Research Personnel; Research Project Grants; Resources; Rodent Model; Science; Services; Sex Differences; Social Environment; Structure; System; Thea Plant; Time; Training; United States National Institutes of Health; Universities; Work; Youth; addiction; adolescent alcohol exposure; alcohol consequences; alcohol effect; alcohol exposure; alcohol related problem; alcohol research; alcohol use disorder; behavioral study; binge drinking; design; experience; graduate student; innovation; longitudinal analysis; multidisciplinary; nervous system development; neuroadaptation; neurobehavioral; neurodevelopment; prenatal; psychosocial; recruit; relating to nervous system; sex; social anxiety; synergism; underage drinking

The Developmental Exposure Alcohol Research Center (DEARC) is a successful, rapidly evolving alcohol research center that has been funded by NIAAA since 2009. The DEARC is an integrative, multidisciplinary center located at Binghamton University, one of four University Centers within the State University of New York (SUNY) system. The DEARC is unique in its focus on basic research to examine functional effects and neural consequences of ethanol exposure throughout extended periods of central nervous system development - inquiries that are of particular importance given the increasing recognition that alcoholism is a disorder with strong roots in development. Through the use of integrative research teams with broad interdisciplinary expertise and experience, the DEARC is distinctively positioned to focus its research efforts on determining the interactions between neurodevelopmental processes and alcohol, with a particular focus on two key points in development when the immature nervous system is particularly likely to be exposed to alcohol: prenatally through maternal alcohol consumption and during adolescence, when many youth first initiate alcohol use. The DEARC will include four Main research components that use established rodent models and integrative cellular, molecular, genomic, neuroanatomical, physiological and behavioral studies to explore functional and neural consequences of developmental exposures to alcohol. Projects also include an emphasis on sex-specific neurobehavioral processes, such as social context and anxiety, that promote alcohol consumption during adolescence. Pilot projects will be vetted and supported by a Pilot Project Core designed to further strengthen the DEARC while encouraging the development of new alcohol researchers. Critical support for all projects is provided by thea Behavioral Resources, Analysis and Integative Neuroscience (BRAIN) Core to support and integrate projects with genomic, molecular, and neuroanatomical expertise. Management, oversight and coordination of scientific effort is provided by an Administrative Core. The over-arching theme for these projects is that exposure of the developing nervous system to alcohol alters neural development and influences later responsiveness to alcohol in ways that exacerbate the normal propensity for enhanced alcohol use during adolescence, thereby increasing the probability of alcohol use and abuse in adulthood.

发展暴露酒精研究中心（DEARC）是一个成功的，快速发展的 酒精研究中心自2009年以来一直由NIAAA资助。 DEARC是一个综合性的， 多学科中心位于宾厄姆顿大学，四个大学中心之一， 纽约的州立大学系统。DEARC的独特之处在于它专注于基础研究 研究长期暴露于乙醇的功能效应和神经后果， 中枢神经系统发育的时期-特别重要的询问， 越来越多的人认识到酗酒是一种有着强烈发展根源的疾病。通过 利用具有广泛的跨学科专业知识和经验的综合研究团队， DEARC的独特定位是将其研究工作集中在确定相互作用上 神经发育过程和酒精之间的关系，特别关注两个关键点， 当不成熟的神经系统特别容易暴露在酒精中时的发育： 产前通过母亲饮酒和在青春期，当许多青年第一次 开始使用酒精。DEARC将包括四个主要的研究组成部分， 啮齿动物模型和整合的细胞、分子、基因组、神经解剖、生理和 行为研究，以探索发育暴露的功能和神经后果 酒精项目还包括强调 特定于性别的神经行为过程，例如促进酒精的社会背景和焦虑 消费 在青春期。试点项目将由试点项目核心审查和支持， 进一步加强DEARC，同时鼓励新的酒精研究人员的发展。关键 对所有项目的支持都是由行为资源、分析和整合提供的。 神经科学（脑）核心支持和整合项目与基因组，分子， 神经解剖学专业知识。提供科学工作的管理、监督和协调 一个行政核心。这些项目的过度主题是， 神经系统对酒精的发育会改变神经发育并影响后期反应 酒精的方式，加剧了正常的倾向，增强酒精使用期间 青少年，从而增加了成年后使用和滥用酒精的可能性。