Core C: Imaging-Abou Alaiwa

核心C-成像 项目总结 囊性纤维化是一种常见的常染色体隐性遗传病，由编码 囊性纤维化跨膜电导调节剂(CFTR)。Cf影响多个器官，包括肺部， 胰腺、肠道、肝脏、汗腺、胆囊腺和男性生殖道。呼吸道感染和 目前，炎症是导致大多数发病率和死亡率的原因。尽管有几种治疗方法已经有所改善 尽管目前的治疗方法不足以挽救患者的生命，但它仍然是一种致命的疾病。我们的知识 关于疾病的发病机制和进展，以及新生儿肺的状态是 不够充分。我们知识上的这些差距阻碍了开发更好的治疗方法和 慢性阻塞性肺疾病的预防。解决这些问题的一个主要障碍是 目前的动物模型。Cf猪复制了人类Cf疾病的许多关键特征，包括肠道 梗阻、胰腺外分泌破坏、微小胆囊症、输精管异常、胆管局灶性病变 肝硬化、先天性呼吸道结构异常，以及随时间推移的呼吸道和鼻窦感染。影像 CORE有两个主要目标：(1)为获取图像提供科学支持、专业知识和资源 数据集和后续分析；以及(2)帮助项目负责人成功实现其目标 项目。最先进的图像采集技术和分析工具可在 爱荷华州立大学为这些项目。成像核心将通过已建立的 与项目负责人、核心主管、转化性肺成像研究计划以及 爱荷华州综合肺部成像中心。

CORE C – IMAGING PROJECT SUMMARY Cystic fibrosis (CF) is a common autosomal recessive disease caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). CF affects multiple organs, including lungs, pancreas, intestine, liver, sweat glands, gallbladder and the male productive tract. Airway infection and inflammation currently cause most of the morbidity and mortality. Although several therapies have improved the lives of patients, current treatments are inadequate and CF remains a lethal disease. Our knowledge about the pathogenesis and the progression of the disease, as well as the state of the neonatal lung is inadequate. These gaps in our knowledge have hindered attempts to develop better treatments and preventions for CF lung disease. A major impediment to addressing these issues has been limitations of current animal models. CF pigs replicate many of the key features of human CF disease including intestinal obstruction, exocrine pancreatic destruction, micro-gallbladder, vas deferens abnormalities, focal biliary cirrhosis, congenital airway structural abnormalities, and airway and sinus infection with time. The Imaging Core has two main objectives: (1) Provide scientific support, expertise, and resources for acquisition of image datasets and subsequent analysis; and (2) Help Project Leaders successfully accomplish the aims of their Projects. State-of-the-art image acquisition technology and analysis tools are readily available at the University of Iowa for these Projects. The Imaging Core will function seamlessly through already established interactions with the Project Leaders, Core Directors, the Translational Lung Imaging Research Program, and the Iowa Comprehensive Lung Imaging Center.