Tanzania AIDS Malignancies Training and Research Program (TAMTRP)

坦桑尼亚艾滋病恶性肿瘤培训和研究计划 (TAMTRP)

• 批准号: 10472142
• 负责人: Julius David Mwaiselage
• 金额: $ 29.36万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10472142
• 关键词: AIDS prevention; AIDS related cancer; Acquired Immunodeficiency Syndrome; Big Data Methods; Bioinformatics; Biology; Biometry; Cancer Biology; Cancer Center; Cancer Detection; Cancer Research Infrastructure; Clinical; Clinical Research; Clinical Trials; Collaborations; Detection; Diagnosis; Diagnostic; Diagnostics Research; Doctor of Philosophy; Educational workshop; Epidemiology; Etiology; Future; Genomics; Goals; Health Personnel; Health Sciences; Human Resources; Immunology; Infrastructure; Institutes; Institution; Instruction; Laboratories; Louisiana; Malignant Neoplasms; Master' s Degree; Mentors; Methodology; Molecular; Molecular Biology; Oceans; Oncology; Pathology; Preparation; Prevention; Public Health; Research; Research Training; Tanzania; Training; Training and Infrastructure; Translational Research; Universities; Viral; anticancer research; base; cancer genomics; cancer prevention; cancer therapy; data management; design; experience; genomic epidemiology; insight; molecular pathology; neoplasm registry; next generation sequencing; precision oncology; programs; training opportunity; virology

Abstract The overall objective of the proposed Tanzania AIDS Malignancies Training and Research Program (TAMTRP) is to enhance the cancer research capacity of the major cancer research institution in Tanzania, the Ocean Road Cancer Institute (ORCI) in partnership with the Stanley S. Scott Cancer Center (SSSCC) at the Louisiana State University Health Science Center in New Orleans (LSUHSC-NO). The proposed program will build onto our existing collaboration, prepare ORCI personnel to fill gaps in expertise while preparing for the future of HIV associated cancer diagnostics and research in cancer genomics and therapy. The scientific focus of TAMTRP is research and training in molecular detection/diagnosis, and in quantifying the epidemiology and biology of the most common HIV associated malignancies in Tanzania, especially those with infectious etiology. The short-term goals are: 1) to enhance the ORCI cancer research and training infrastructure. 2) Institute a training and mentoring program for Tanzanians to conduct research on cancers that are commonly encountered at ORCI and SSSCC. These goals will be accomplished through three specific aims: 1) Provide intensive academic instruction and research experience for two PhD and four Master's degree candidates in a relevant HIV associated cancer research field. 2) Provide medium-term (three to six months) technical training opportunities for post-graduates and health care providers in topics related to molecular pathology, cancer biology, bioinformatics, genomics, biostatistics, bio banking, cancer registry, as well as clinical and translational research. 3) Deliver technical workshops designed to enhance basic, clinical, implementation, genomics, bioinformatics, computation genomics, epidemiology, biostatistics, and continue to expand collaborations between partner institutions to enhance the research capability and infrastructure in Tanzania. There are four training tracks: a) clinical trials methodologies and management; b) public health operational and translational research– including cancer prevention, biostatistics and data management, epidemiology, cancer registry, and bio banking; c) laboratory-based cancer biology research– including molecular biology/virology, pathology, diagnostics, viral oncology, and immunology; d) cancer genomics and bioinformatics–including next generation sequencing, data management, big data analytics, and computational genomics. TAMTRP will be critical in the preparation of ORCI (and Tanzania) for the era of personalized and precision cancer medicine, which will utilize cancer genomics for cancer detection, diagnosis, prevention, and treatment. It will provide important insight in the understanding and prevention of HIV associated and non-HIV associated malignancies in Tanzania, and reciprocally, in the U.S.

摘要 拟议的坦桑尼亚艾滋病恶性疾病培训和研究方案(TAMTRP)的总体目标 是增强坦桑尼亚主要癌症研究机构The Ocean的癌症研究能力 道路癌症研究所(ORCI)与路易斯安那州斯坦利·S·斯科特癌症中心(SSSCC)合作 新奥尔良州立大学健康科学中心(LSUHSC-NO)。拟议的计划将建立在 我们现有的合作，使Orci人员做好准备，以填补专业知识的空白，同时为未来的艾滋病毒做准备 相关癌症诊断以及癌症基因组学和治疗研究。TAMTRP的科学焦点 是在分子检测/诊断方面的研究和培训，以及在量化疟疾流行病学和生物学方面的研究和培训 坦桑尼亚最常见的艾滋病毒相关恶性肿瘤，特别是那些具有感染性病原学的癌症。这个 短期目标是：1)加强Orci癌症研究和培训基础设施。2)建立一个 为坦桑尼亚人开展癌症研究的培训和指导计划 在Orci和SSSCC遇到过。这些目标将通过三个具体目标来实现：1)提供 在一年中为两名博士和四名硕士研究生提供密集的学术指导和研究经验 相关的艾滋病毒相关癌症研究领域。2)提供中期(三至六个月)技术培训 为研究生和医疗保健提供者提供与分子病理学、癌症相关主题的机会 生物学、生物信息学、基因组学、生物统计学、生物银行、癌症登记以及临床和翻译 研究。3)举办旨在加强基础、临床、实施、基因组学、 生物信息学、计算基因组学、流行病学、生物统计学，并继续扩大合作 合作机构之间的合作，以加强坦桑尼亚的研究能力和基础设施。一共有四个 培训轨道：a)临床试验方法和管理；b)公共卫生业务和翻译 研究--包括癌症预防、生物统计和数据管理、流行病学、癌症登记和 生物银行；c)基于实验室的癌症生物学研究--包括分子生物学/病毒学、病理学、 诊断学、病毒肿瘤学和免疫学；d)癌症基因组学和生物信息学--包括下一代 测序、数据管理、大数据分析和计算基因组学。TAMTRP将在 为个性化和精确癌症药物时代准备ORCI(和坦桑尼亚)，这将 利用癌症基因组学进行癌症检测、诊断、预防和治疗。它将提供重要的 对艾滋病相关和非艾滋病相关恶性肿瘤的认识和预防 坦桑尼亚，以及反过来，在美国。