Tanzania AIDS Malignancies Training and Research International Program (TAMTRP)

坦桑尼亚艾滋病恶性肿瘤培训和研究国际计划 (TAMTRP)

• 批准号: 10650673
• 负责人: Julius David Mwaiselage
• 金额: $ 10万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10650673
• 关键词: AIDS related cancer; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Africa South of the Sahara; Area; Caring; Characteristics; Clinic; Clinical; Community Healthcare; Data; Documentation; Failure; Future; HIV; Health; Health Personnel; Healthcare; Institutes; International; Investigation; Kaposi Sarcoma; Lead; Malignant Neoplasms; Mentors; Oceans; Oncologist; Outcome; Outcome Measure; Patients; Pattern; Reporting; Research; Research Personnel; Survival Rate; Talents; Tanzania; Testing; Training; Treatment outcome; career; cohort; data quality; design; follow-up; implementation research; improved; programs; research study; skills; sociodemographics; treatment response

PROJECT SUMMARY/ABSTRACT Despite the highest Kaposi’s sarcoma (KS) burden in the world, treatment outcome data is scarce in sub- Saharan Africa (SSA), making meaningful comparisons of SSA with other regions difficult. The 5-year survival rate of HIV-associated KS is reportedly as low as 9%. Failure to keep PLWH closely connected to healthcare beyond ART leads to loss of follow-up that contributes to poor treatment response and outcomes. Reports in SSA have documented up to 40% loss to follow-up leading to poor data quality and making outcome measures unfeasible. Lack of proper documentation of sociodemographic, clinicopathological characteristics, and objective assessment of treatment responses and outcomes have led to the limited interpretation of outcomes in SSA. Currently, ORCI attends ~120 KS patients annually, however, it is evident that there is a limited linkage between HIV and KS care leading to the scattering of important clinical and outcome information. Therefore, there is a need to develop, test, and implement strategies to enhance the linkages and outcomes. This need is further compounded by a lack of well- trained researchers in HIV-associated cancers to address this area of need. We are proposing to mentor a junior oncologist who can lead a study in establishing a clinical cohort of KS patients at Ocean Road Cancer Institute (ORCI) in Tanzania, and test whether the engagement of the HIV care and treatment clinic (CTC) and community healthcare workers enhance follow-ups of KS patients and improve data on KS treatment response and outcomes. We have now identified a talented junior oncologist who is committed to a clinical and operational research career in HIV-associated cancers to lead the proposed study. We hypothesize that surrounding KS patients with a clinical team that maintains contact and answers questions will enable the investigation of short- and long-term outcomes in KS treatment and will help define barriers against and facilitators of connection to care. To test this hypothesis, the project team will: a) determine socio-demographic and clinical characteristics of a cohort of Kaposi’s sarcoma patients at ORCI, b) determine the treatment patterns and outcomes of Kaposi’s Sarcoma patients in relation to sociodemographic and clinical characteristics, and c) evaluate barriers and facilitators of retention in care for KS patients attending ORCI. The proposed supplement project is significant as it provides a unique opportunity for a new investigator to acquire new skills in HIV clinical, operational, and implementation research as a stepping-stone to embark on HIV/AIDS research career and improve research capacity in Tanzania. Moreover, the study will provide outcomes and barriers information for future HIV research studies, and for designing strategies to improve the health outcomes of PLWH in Tanzania and beyond.

项目摘要/摘要 尽管卡波西肉瘤(KS)的负担是世界上最高的，但在 撒哈拉非洲(SSA)，这使得将SSA与其他地区进行有意义的比较变得困难。五年制 据报道，艾滋病毒相关KS的存活率低至9%。未能保持与PLWH的密切联系 超出抗逆转录病毒治疗的医疗保健会导致随访的损失，从而导致治疗反应和 结果。SSA中的报告记录了高达40%的跟踪损失，导致数据质量较差 使结果衡量标准变得不可行。缺乏适当的社会人口统计文件， 临床病理特征，以及治疗反应和结果的客观评估 导致对特别服务协议结果的解释有限。目前，Orci每年治疗约120名KS患者， 然而，很明显，艾滋病毒和KS护理之间的联系有限，导致分散在 重要的临床和结果信息。因此，需要开发、测试和实现 加强联系和成果的战略。这一需求由于缺乏良好的- 对艾滋病毒相关癌症的研究人员进行培训，以解决这一需求领域。我们提议指导一位 初级肿瘤学家，可以领导一项研究，在海洋路建立KS患者的临床队列 在坦桑尼亚的癌症研究所(ORCI)，并测试是否参与艾滋病毒护理和治疗诊所 (CTC)和社区医护人员加强对KS患者的随访，改善KS数据 治疗反应和结果。我们现在已经确定了一位才华横溢的初级肿瘤学家，他致力于 在HIV相关癌症的临床和操作研究生涯中领导这项拟议的研究。我们 假设KS患者周围有一个临床团队，保持联系并回答问题 将能够调查KS治疗的短期和长期结果，并将有助于确定障碍 反对和促进护理联系的人。为了验证这一假设，项目团队将：a)确定 Orci，b)卡波西肉瘤患者队列的社会人口学和临床特征 确定卡波西肉瘤患者的治疗模式和结果 社会人口学和临床特征，以及c)评估保留护理的障碍和促进因素 对于在Orci就诊的KS患者。拟议的补充项目意义重大，因为它提供了一个独特的 为新的研究人员提供在艾滋病毒临床、操作和实施方面获得新技能的机会 将研究作为踏上艾滋病毒/艾滋病研究事业和提高#年研究能力的垫脚石 坦桑尼亚。此外，这项研究将为未来的艾滋病毒研究提供结果和障碍信息 研究，并设计战略，以改善坦桑尼亚及其他地区的妇女和儿童的健康状况。