Tanzania AIDS Malignancies Training and Research Program (TAMTRP)

坦桑尼亚艾滋病恶性肿瘤培训和研究计划 (TAMTRP)

• 批准号: 10601111
• 负责人: Julius David Mwaiselage
• 金额: $ 29.13万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10601111
• 关键词: AIDS prevention; AIDS related cancer; Acquired Immunodeficiency Syndrome; Big Data Methods; Bioinformatics; Biology; Biometry; Cancer Biology; Cancer Center; Cancer Detection; Cancer Diagnostics; Cancer Research Infrastructure; Clinical; Clinical Research; Clinical Trials; Collaborations; Detection; Diagnosis; Diagnostic; Doctor of Philosophy; Educational workshop; Epidemiology; Etiology; Future; Genomics; Goals; Health Personnel; Health Sciences; Human Resources; Immunology; Infrastructure; Institution; Instruction; Laboratories; Louisiana; Malignant Neoplasms; Master of Science; Mentors; Methodology; Molecular; Molecular Biology; Oceans; Oncology; Pathology; Preparation; Prevention; Public Health; Research; Tanzania; Training; Training and Infrastructure; Translational Research; Universities; Viral; anticancer research; cancer genomics; cancer prevention; cancer therapy; data management; design; experience; insight; molecular pathology; neoplasm registry; next generation sequencing; precision oncology; programs; training opportunity; virology

Abstract The overall objective of the proposed Tanzania AIDS Malignancies Training and Research Program (TAMTRP) is to enhance the cancer research capacity of the major cancer research institution in Tanzania, the Ocean Road Cancer Institute (ORCI) in partnership with the Stanley S. Scott Cancer Center (SSSCC) at the Louisiana State University Health Science Center in New Orleans (LSUHSC-NO). The proposed program will build onto our existing collaboration, prepare ORCI personnel to fill gaps in expertise while preparing for the future of HIV associated cancer diagnostics and research in cancer genomics and therapy. The scientific focus of TAMTRP is research and training in molecular detection/diagnosis, and in quantifying the epidemiology and biology of the most common HIV associated malignancies in Tanzania, especially those with infectious etiology. The short-term goals are: 1) to enhance the ORCI cancer research and training infrastructure. 2) Institute a training and mentoring program for Tanzanians to conduct research on cancers that are commonly encountered at ORCI and SSSCC. These goals will be accomplished through three specific aims: 1) Provide intensive academic instruction and research experience for two PhD and four Master's degree candidates in a relevant HIV associated cancer research field. 2) Provide medium-term (three to six months) technical training opportunities for post-graduates and health care providers in topics related to molecular pathology, cancer biology, bioinformatics, genomics, biostatistics, bio banking, cancer registry, as well as clinical and translational research. 3) Deliver technical workshops designed to enhance basic, clinical, implementation, genomics, bioinformatics, computation genomics, epidemiology, biostatistics, and continue to expand collaborations between partner institutions to enhance the research capability and infrastructure in Tanzania. There are four training tracks: a) clinical trials methodologies and management; b) public health operational and translational research– including cancer prevention, biostatistics and data management, epidemiology, cancer registry, and bio banking; c) laboratory-based cancer biology research– including molecular biology/virology, pathology, diagnostics, viral oncology, and immunology; d) cancer genomics and bioinformatics–including next generation sequencing, data management, big data analytics, and computational genomics. TAMTRP will be critical in the preparation of ORCI (and Tanzania) for the era of personalized and precision cancer medicine, which will utilize cancer genomics for cancer detection, diagnosis, prevention, and treatment. It will provide important insight in the understanding and prevention of HIV associated and non-HIV associated malignancies in Tanzania, and reciprocally, in the U.S.

摘要 拟议的坦桑尼亚艾滋病防治培训和研究方案的总体目标 是为了提高坦桑尼亚主要癌症研究机构的癌症研究能力， 道路癌症研究所（ORCI）与斯坦利S。路易斯安那州斯科特癌症中心（SSSCC） 新奥尔良州立大学健康科学中心（LSUHSC-NO）。该计划将建立在 我们现有的合作，准备ORCI人员填补专业知识的空白，同时为艾滋病毒的未来做好准备 相关的癌症诊断和癌症基因组学和治疗研究。TAMTRP的科学重点 是分子检测/诊断以及量化流行病学和生物学的研究和培训 坦桑尼亚最常见的HIV相关恶性肿瘤，尤其是感染性病因。的 短期目标是：1）加强ORCI癌症研究和培训基础设施。2)建立一个 培训和指导计划，为坦桑尼亚人进行癌症研究， 在ORCI和SSSCC中遇到。这些目标将通过三个具体目标来实现：1）提供 密集的学术指导和研究经验，两个博士和四个硕士学位的候选人在一个 艾滋病相关癌症研究领域。2)提供中期（三至六个月）技术培训 为研究生和卫生保健提供者提供与分子病理学，癌症 生物学，生物信息学，基因组学，生物统计学，生物银行，癌症登记，以及临床和翻译 research. 3)提供旨在加强基础、临床、实施、基因组学、 生物信息学、计算基因组学、流行病学、生物统计学，并继续扩大合作 合作伙伴机构之间的合作，以提高坦桑尼亚的研究能力和基础设施。有四 培训方向：a）临床试验方法和管理; B）公共卫生操作和转化 研究-包括癌症预防、生物统计学和数据管理、流行病学、癌症登记，以及 生物银行; c）基于实验室的癌症生物学研究-包括分子生物学/病毒学，病理学， 诊断学、病毒肿瘤学和免疫学; d）癌症基因组学和生物信息学----包括下一代 测序、数据管理、大数据分析和计算基因组学。TAMTRP将是至关重要的， 准备ORCI（和坦桑尼亚）的个性化和精确的癌症医学时代，这将 利用癌症基因组学进行癌症检测、诊断、预防和治疗。它将提供重要的 深入了解和预防艾滋病毒相关和非艾滋病毒相关的恶性肿瘤， 坦桑尼亚，以及美国的坦桑尼亚。