Immunoengineering Postdoctoral Training Program - Resubmission - 1

项目摘要/摘要 这一新的免疫工程博士后培训计划(ImEPosT)的目标是培养一名新的 新兴免疫工程领域的跨学科科学家一代，通过利用 芝加哥大学导师在确定免疫学中最紧迫的问题和 再加上不断增长的生物工程师队伍，他们创造了新的工具、技术和算法来 推动技术边界来解决这些问题。由36人组成的合议性和凝聚力的机构支撑 普利兹克分子工程学院(PME)和生物科学部的导师 (BSD)，ImEPosT计划将从生物工程和 免疫学背景参加一项为期两年的跨国合作研究计划 免疫学-生物工程接口，包括灵活的教学组件，以建立重要的技能，如 项目开发和管理、赠款撰写、教学、科学交流、外展和职业生涯 计划。在实验室，导师在六个主要领域拥有专业知识：(A)过敏、自身免疫和 移植；(B)疫苗；(C)免疫肿瘤学；(D)细胞和分子免疫学；(E)计算 和系统免疫学；和(F)微生物组。这些相互重叠的专业领域创造了一个 协作项目组合。这些措施包括通过计算机模拟改善疫苗接种结果 佐剂对免疫系统的影响；描述佐剂的分子机制的系统方法 共生微生物与免疫系统和消化系统之间的沟通，导致 动态平衡与疾病的关系；模拟早期中性粒细胞聚集和激活的器官类型装置 炎症激活；传递细胞因子受体的蛋白质工程和计算方法 “超级激动剂”作为疫苗或癌症免疫疗法中的佐剂。归根结底，整个地区正在进行的项目 36个参与PME和BSD的实验室寻求使用非传统方法来提供新的见解 免疫学方面的知识差距，纠正免疫功能障碍或功能丧失的治疗方法，以及 诊断以确定潜在的干预途径。由教授领导。梅洛迪·A·斯沃茨和玛丽亚-路易莎·阿莱格雷， 由Shann S.Yu博士(芝加哥免疫工程创新中心科学主任)担任项目 作为管理人员，ImEPosT计划将建立在以下位置的博士后培训基础设施之上 芝加哥大学及其教职员工在指导以前的实习生进入成功的职业生涯方面取得了成功的历史 学术界、政府和工业界创建一个新计划，以满足以下领域的新兴工程需求 快速发展的免疫病理学和免疫治疗领域。

PROJECT SUMMARY / ABSTRACT The objective of this new Immuno-Engineering Postdoctoral Training (ImEPosT) Program is to train a new generation of interdisciplinary scientists in the emerging field of immunoengineering, by taking advantage of the strengths of University of Chicago mentors in identifying the most pressing questions in immunology and combining that with a growing body of bioengineers who create new tools, technologies, and algorithms to push the technical boundaries to address those questions. Anchored by a collegial and cohesive body of 36 mentors across the Pritzker School of Molecular Engineering (PME) and the Biological Sciences Division (BSD), The ImEPosT program will select the most promising postdoctoral trainees from bioengineering and immunology backgrounds to participate on a two-year program of collaborative research across the immunology-bioengineering interface that includes a flexible didactic component to build important skills like project development and management, grant writing, teaching, science communication, outreach, and career planning. In the laboratory, the mentors have expertise in six major areas: (A) Allergy, Autoimmunity, & Transplantation; (B) Vaccines; (C) Immuno-oncology; (D) Cellular & Molecular Immunology; (E) Computational & Systems Immunology; and (F) Microbiome. These mutually-overlapping areas of expertise have created a portfolio of collaborative projects. These include improving vaccination outcomes through in silico modeling of the effects of adjuvants on the immune system; systems approaches to delineate the molecular mechanisms of communication between commensal microbes with the immune system and the digestive system that lead to homeostasis versus disease; organotypic devices to model neutrophil swarming and activation during early inflammatory activation; protein engineering and computational approaches to deliver cytokine receptor `superagonists' as adjuvants in vaccines or cancer immunotherapies. Ultimately, ongoing projects across the 36 participating PME and BSD laboratories seek to use unconventional approaches to deliver new insights to gaps in knowledge in immunology, therapies that correct immunologic dysfunction or loss-of-function, and also diagnostics to identify potential routes of intervention. Led by Profs. Melody A. Swartz and Maria-Luisa Alegre, with Dr. Shann S. Yu (Scientific Director of the Chicago Immunoengineering Innovation Center) as the program administrator, the ImEPosT program will build on an outstanding infrastructure for postdoctoral training at UChicago together with a history of success of its faculty in mentoring prior trainees into successful careers in academia, government, and industry to create a new program that addresses emerging engineering needs in the rapidly evolving fields of immunopathology and immunotherapy.