Immunoengineering Postdoctoral Training Program - Resubmission - 1

项目概要/摘要 这个新的免疫工程博士后培训（ImEPosT）计划的目标是培养一个新的 在新兴的免疫工程领域产生跨学科科学家，利用 芝加哥大学导师在确定免疫学中最紧迫问题方面的优势， 结合不断增长的生物工程师，他们创造新的工具，技术和算法， 突破技术界限来解决这些问题。由36名成员组成的合议和有凝聚力的机构 普利兹克分子工程学院（PME）和生物科学部的导师 (BSD)，ImEPosT计划将从生物工程领域挑选最有前途的博士后培训生， 免疫学背景，参加为期两年的合作研究计划， 免疫学-生物工程接口，包括一个灵活的教学组件，以建立重要的技能，如 项目开发和管理，拨款写作，教学，科学交流，推广和职业生涯 规划在实验室里，导师们在六个主要领域有专长：（A）过敏，自身免疫， 移植;（B）疫苗;（C）免疫肿瘤学;（D）细胞和分子免疫学;（E）计算 和系统免疫学;和（F）微生物组。这些相互重叠的专业领域创造了一个 合作项目组合。这些措施包括通过计算机模拟来改善疫苗接种结果， 佐剂对免疫系统的影响;阐明免疫系统的分子机制的系统方法 肠道微生物与免疫系统和消化系统之间的沟通， 内稳态与疾病;器官型装置模拟早期中性粒细胞群集和激活 炎症激活;传递细胞因子受体的蛋白质工程和计算方法 “超激动剂”作为疫苗或癌症免疫疗法中的佐剂。最后，整个非洲正在进行的项目 36个参与的PME和BSD实验室寻求使用非常规方法来提供新的见解， 免疫学知识的空白，纠正免疫功能障碍或功能丧失的疗法，以及 诊断，以确定潜在的干预途径。由教授带领。梅洛迪·A斯沃茨和玛丽亚-路易莎阿莱格雷， Shann S博士Yu（芝加哥免疫工程创新中心科学总监）作为该计划的 管理员，ImEPosT计划将建立在博士后培训的优秀基础设施上， 芝加哥大学及其教师在指导以前的学员进入成功的职业生涯的成功历史， 学术界，政府和工业界创建一个新的计划，以解决新兴的工程需求， 快速发展的免疫病理学和免疫疗法领域。

PROJECT SUMMARY / ABSTRACT The objective of this new Immuno-Engineering Postdoctoral Training (ImEPosT) Program is to train a new generation of interdisciplinary scientists in the emerging field of immunoengineering, by taking advantage of the strengths of University of Chicago mentors in identifying the most pressing questions in immunology and combining that with a growing body of bioengineers who create new tools, technologies, and algorithms to push the technical boundaries to address those questions. Anchored by a collegial and cohesive body of 36 mentors across the Pritzker School of Molecular Engineering (PME) and the Biological Sciences Division (BSD), The ImEPosT program will select the most promising postdoctoral trainees from bioengineering and immunology backgrounds to participate on a two-year program of collaborative research across the immunology-bioengineering interface that includes a flexible didactic component to build important skills like project development and management, grant writing, teaching, science communication, outreach, and career planning. In the laboratory, the mentors have expertise in six major areas: (A) Allergy, Autoimmunity, & Transplantation; (B) Vaccines; (C) Immuno-oncology; (D) Cellular & Molecular Immunology; (E) Computational & Systems Immunology; and (F) Microbiome. These mutually-overlapping areas of expertise have created a portfolio of collaborative projects. These include improving vaccination outcomes through in silico modeling of the effects of adjuvants on the immune system; systems approaches to delineate the molecular mechanisms of communication between commensal microbes with the immune system and the digestive system that lead to homeostasis versus disease; organotypic devices to model neutrophil swarming and activation during early inflammatory activation; protein engineering and computational approaches to deliver cytokine receptor `superagonists' as adjuvants in vaccines or cancer immunotherapies. Ultimately, ongoing projects across the 36 participating PME and BSD laboratories seek to use unconventional approaches to deliver new insights to gaps in knowledge in immunology, therapies that correct immunologic dysfunction or loss-of-function, and also diagnostics to identify potential routes of intervention. Led by Profs. Melody A. Swartz and Maria-Luisa Alegre, with Dr. Shann S. Yu (Scientific Director of the Chicago Immunoengineering Innovation Center) as the program administrator, the ImEPosT program will build on an outstanding infrastructure for postdoctoral training at UChicago together with a history of success of its faculty in mentoring prior trainees into successful careers in academia, government, and industry to create a new program that addresses emerging engineering needs in the rapidly evolving fields of immunopathology and immunotherapy.