1/3 Florida-California Cancer Research, Education and Engagement (CaRE2) Health Equity Center

总体--项目摘要 佛罗里达-加州癌症研究、教育和参与(Care2)健康公平计划由 佛罗里达大学(UF)、佛罗里达农工大学(FAMU)和南加州大学诺里斯分校 综合癌症中心(USC-NCCC)，以消除佛罗里达州、加利福尼亚州和 全国范围内。Care2中心的长期目标是减少黑人和拉丁裔的癌症差异，以 培训和增加代表不足的黑人和拉丁裔科学家进行健康差距研究， 增加FAMU的研究能力，并增加UF和USC-NCCC的癌症差异研究。这个 两个沿海地区的位置提供了接触独特多样化的黑人和拉丁裔人口的途径，促进了 以前所未有的方式，研究这些令人难以置信的异质人群中的癌症差异。具体来说， 该中心将专注于研究相关问题并满足以下人群的需求：(1)黑人亚群，包括 美国出生的、非洲出生的和加勒比出生的黑人；以及(2)包括墨西哥人在内的拉丁裔亚群-- 美国人、加勒比拉美人、中美洲人和南美洲人。这个黑社会组织把调查人员和 目前癌症发病率和死亡率最高的两个美国州的机构。主要的科学研究 该中心的重点是研究不同种族少数民族之间的翻译差异，重点是 以高死亡率著称的癌症。我们建议将专业知识、基础设施和共享资源整合到 支持6个创新的翻译研究项目，重点是了解糖尿病的生物学基础 黑人和拉丁裔人口的差异，反映了这两个群体的广泛异质性，有两个 以胰腺癌为重点的基础项目(一个全面项目，一个试点项目)和一个以前列腺癌为重点的全面项目 癌症(目标1)。在研究教育核心的领导下，我们建议培训100名黑人和拉丁裔 研究人员，包括学生和早期调查人员(ESI)，在翻译癌症健康差异中 研究(目标2)。将利用外联核心中现有的社区伙伴关系传播调查结果 在黑人和拉丁裔社区，教育胰腺和前列腺癌，并提高参与 生物医学研究(目标3)。最后，规划和评价核心将实施系统规划和 使用创新战略改进中心有效性的评估计划(目标4)。所有的研究项目都将 在组织建模核心和生物信息学提供的资源和方法的推动和丰富下， 统计和方法核心。Care2中心的所有活动将由 管理核心。FAMU-UF-USC的合作伙伴关系非常适合实现这些目标。UF和FAMU 在过去的4年里一直密切合作解决佛罗里达黑人的癌症差异问题。南加州大学-NCCC 为拉丁裔提供癌症差异研究、研究培训方面的互补和协同专业知识 人口，以及开发对文化敏感的工具以减少拉美裔癌症差异的专业知识。

Overall- Project Summary The Florida-California Cancer Research, Education & Engagement (CaRE2) Health Equity is proposed by the University of Florida (UF), Florida A&M University (FAMU) and the University of Southern California-Norris Comprehensive Cancer Center (USC-NCCC) to eliminate cancer health disparities in Florida, California and nationally. The long term goals of the CaRE2 center are to reduce cancer disparities in Blacks and Latinos, to train and increase the pool of underrepresented Black and Latino scientists conducting health disparity research, to increase research capacity at FAMU, and to increase cancer disparity research at UF and USC-NCCC. The bi-coastal location offers access to uniquely diverse populations of Blacks and Latinos, facilitating in an unprecedented way, the study of cancer disparities in these incredibly heterogeneous populations. Specifically, the center will focus on studying relevant issues and serving the needs of: (1) Black subpopulations, including American-born, African-born and Caribbean-born Blacks; and (2) Latino subpopulations including Mexican- Americans, Caribbean Latinos, Central and South Americans. This triad brings together investigators and institutions in the two US states that currently have the highest cancer incidence and mortality. The main scientific focus of the center is translational disparities research among heterogeneous minority populations focusing on cancers known for high mortality. We propose to coalesce expertise, infrastructure and share resources in support of 6 innovative translational research projects focused on understanding the biological basis of disparities in Black and Latino populations, capturing the wide heterogeneity within these two groups, with two foundational projects focusing on pancreas cancer (one full, one pilot) and one full project focusing on prostate cancer (Aim 1). Under the leadership of the Research Education Core, we propose to train 100 Black and Latino investigators, including students and early stage investigators (ESI), in translational cancer health disparity research (Aim 2). Existing community partnerships in the Outreach Core will be leveraged to disseminate findings in the Black and Latino community, educate about pancreas and prostate cancer, and improve participation in biomedical research (Aim 3). Finally, the Planning and Evaluation Core will implement a systematic planning and evaluation plan to improve Center effectiveness using innovative strategies (Aim 4). All research projects will be facilitated and enriched by resources and approaches provided by the Tissue Modeling Core and Bioinformatics, Statistical and Methodological Core. All CaRE2 Center’s activities will be centralized and overseen by the Administrative Core. The FAMU-UF-USC partnership is ideally suited to achieve these aims. Both UF and FAMU have worked closely together addressing cancer disparities in Florida Blacks for the last 4 years. USC-NCCC provides complementary and synergistic expertise in cancer disparities research, research training for the Latino population, and expertise in developing culturally-sensitive tools to reduce cancer disparities among Latinos.