1/3 Florida-California Cancer Research, Education and Engagement (CaRE2) Health Equity Center

总体-项目概要 佛罗里达州-加利福尼亚州癌症研究、教育和参与 (CaRE2) 健康公平计划由 佛罗里达大学 (UF)、佛罗里达农工大学 (FAMU) 和南加州大学诺里斯分校 综合癌症中心 (USC-NCCC) 旨在消除佛罗里达州、加利福尼亚州和加利福尼亚州的癌症健康差异 全国范围内。 CaRE2 中心的长期目标是减少黑人和拉丁裔的癌症差异， 培训并增加进行健康差异研究的黑人和拉丁裔科学家的代表性不足的人才库， 提高 FAMU 的研究能力，并加强 UF 和 USC-NCCC 的癌症差异研究。的 位于两岸的地理位置为黑人和拉丁裔独特的多元化人口提供了便利，促进了 以前所未有的方式研究这些极其异质的人群中的癌症差异。具体来说， 该中心将重点研究相关问题并满足以下群体的需求：（1）黑人亚群体，包括 美国出生、非洲出生和加勒比出生的黑人； (2) 拉丁裔亚群体，包括墨西哥裔 美国人、加勒比拉丁裔、中美洲和南美洲人。这个三合会汇集了调查人员和 美国目前癌症发病率和死亡率最高的两个州的机构。主要科学 该中心的重点是异质少数群体之间的转化差异研究，重点是 以高死亡率而闻名的癌症。我们建议整合专业知识、基础设施并共享资源 支持 6 个创新转化研究项目，重点是了解生物基础 黑人和拉丁裔人口的差异，捕捉到这两个群体内广泛的异质性，有两个 重点关注胰腺癌的基础项目（一项完整项目、一项试点项目）和一项重点关注前列腺癌的完整项目 癌症（目标 1）。在研究教育核心的领导下，我们建议培训 100 名黑人和拉丁裔 研究人员，包括学生和早期研究人员 (ESI)，研究转化癌症健康差异 研究（目标 2）。将利用外展核心中现有的社区伙伴关系来传播调查结果 在黑人和拉丁裔社区中，开展有关胰腺癌和前列腺癌的教育，并提高参与 生物医学研究（目标 3）。最后，规划和评估核心将实施系统的规划和评估 使用创新策略提高中心有效性的评估计划（目标 4）。所有研究项目都将 组织建模核心和生物信息学提供的资源和方法促进和丰富， 统计和方法论核心。 CaRE2 中心的所有活动都将由 行政核心。 FAMU-UF-USC 的合作伙伴关系非常适合实现这些目标。 UF 和 FAMU 过去 4 年，我们密切合作，解决佛罗里达州黑人的癌症差异问题。南加州大学NCCC 为拉丁裔提供癌症差异研究和研究培训方面的互补和协同专业知识 人口，以及开发文化敏感工具以减少拉丁裔之间癌症差异的专业知识。

Overall- Project Summary The Florida-California Cancer Research, Education & Engagement (CaRE2) Health Equity is proposed by the University of Florida (UF), Florida A&M University (FAMU) and the University of Southern California-Norris Comprehensive Cancer Center (USC-NCCC) to eliminate cancer health disparities in Florida, California and nationally. The long term goals of the CaRE2 center are to reduce cancer disparities in Blacks and Latinos, to train and increase the pool of underrepresented Black and Latino scientists conducting health disparity research, to increase research capacity at FAMU, and to increase cancer disparity research at UF and USC-NCCC. The bi-coastal location offers access to uniquely diverse populations of Blacks and Latinos, facilitating in an unprecedented way, the study of cancer disparities in these incredibly heterogeneous populations. Specifically, the center will focus on studying relevant issues and serving the needs of: (1) Black subpopulations, including American-born, African-born and Caribbean-born Blacks; and (2) Latino subpopulations including Mexican- Americans, Caribbean Latinos, Central and South Americans. This triad brings together investigators and institutions in the two US states that currently have the highest cancer incidence and mortality. The main scientific focus of the center is translational disparities research among heterogeneous minority populations focusing on cancers known for high mortality. We propose to coalesce expertise, infrastructure and share resources in support of 6 innovative translational research projects focused on understanding the biological basis of disparities in Black and Latino populations, capturing the wide heterogeneity within these two groups, with two foundational projects focusing on pancreas cancer (one full, one pilot) and one full project focusing on prostate cancer (Aim 1). Under the leadership of the Research Education Core, we propose to train 100 Black and Latino investigators, including students and early stage investigators (ESI), in translational cancer health disparity research (Aim 2). Existing community partnerships in the Outreach Core will be leveraged to disseminate findings in the Black and Latino community, educate about pancreas and prostate cancer, and improve participation in biomedical research (Aim 3). Finally, the Planning and Evaluation Core will implement a systematic planning and evaluation plan to improve Center effectiveness using innovative strategies (Aim 4). All research projects will be facilitated and enriched by resources and approaches provided by the Tissue Modeling Core and Bioinformatics, Statistical and Methodological Core. All CaRE2 Center’s activities will be centralized and overseen by the Administrative Core. The FAMU-UF-USC partnership is ideally suited to achieve these aims. Both UF and FAMU have worked closely together addressing cancer disparities in Florida Blacks for the last 4 years. USC-NCCC provides complementary and synergistic expertise in cancer disparities research, research training for the Latino population, and expertise in developing culturally-sensitive tools to reduce cancer disparities among Latinos.