Small-molecule therapy for metastatic castration-resistant prostate cancer

转移性去势抵抗性前列腺癌的小分子治疗

• 批准号: 10472020
• 负责人: DAQING WU
• 金额: $ 92.74万
• 依托单位: METCURE THERAPEUTICS, LLC
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10472020
• 关键词: Affect; Animals; Antineoplastic Agents; Apoptosis; Biological Assay; Bone Tissue; Businesses; Cancer Patient; Cancer cell line; Canis familiaris; Cardiovascular system; Cell Line; Cells; Clinical Pharmacology; Clinical Trials; Collaborations; Complex; Cyclin D1; Developmental Therapeutics Program; Disseminated Malignant Neoplasm; Dose; Drug Kinetics; EZH2 gene; Evolution; Excretory function; Exhibits; F-Box Proteins; Formulation; Future; Generations; Genetic; Grant; Growth; Human; In Vitro; Intervention; Investigational Drugs; Investigational New Drug Application; Lead; Malignant Neoplasms; Malignant neoplasm of prostate; Mass Spectrum Analysis; Medical; Metabolism; Metastatic Neoplasm to the Bone; Modality; Modeling; Molecular Target; Morbidity - disease rate; National Cancer Institute; Oncogenic; Oncology; Oral; Organ; Outcome; Patient Selection; Patients; Pharmaceutical Preparations; Pharmacology; Phase; Phosphotransferases; Pilot Projects; Pre-Clinical Model; Prognosis; Property; Proteins; Proteome; Quality of life; Relapse; Rodent; Rodent Model; Role; S phase; Safety; Sampling; Schedule; Signal Transduction; Solid; Technology Transfer; Testing; Therapeutic; Tissues; Toxic effect; Toxicokinetics; Toxicology; Treatment Efficacy; United States; Ursidae Family; Xenograft Model; Xenograft procedure; abiraterone; absorption; androgen deprivation therapy; base; beta catenin; c-myc Genes; cancer cell; castration resistant prostate cancer; chemotherapy; clinical development; clinically relevant; cytotoxicity; docetaxel; dosage; drug candidate; drug development; efficacious treatment; efficacy study; enzalutamide; follow-up; good laboratory practice; improved; in vivo; inhibitor; innovation; mortality; nanomolar; new therapeutic target; novel; patient derived xenograft model; pre-clinical; preclinical development; preclinical safety; preclinical study; preclinical toxicity; predictive marker; prostate cancer cell; respiratory; skeletal; small molecule; small molecule inhibitor; subcutaneous; survivin; survivorship; targeted treatment; therapeutic target; therapy resistant; trial design; tumor; tumor progression; ubiquitin ligase

Metastatic, castration-resistant prostate cancer (mCRPC) is lethal with no cure. Although current treatments initially prolong survival, patients generally relapse and develop therapeutic resistance, which is a major obstacle in the management of prostate cancer. It is imperative to develop efficacious therapies to treat lethal mCRPC and improve the survivorship of patients. During the Phase I STTR period, we identified a novel small- molecule inhibitor of S phase kinase-associated protein 1 (Skp1) – F-Box protein (FBP) interaction, namely GH501, that exhibits nanomolar potency against mCRPC and a broad spectrum of human cancer cell lines. We have conducted pilot studies on the preclinical safety, pharmacokinetics, distribution and efficacy of GH501 against mCRPC. In this Phase II STTR project, we will test the central hypothesis that our lead compound GH501 is a first-in-class Skp1-FBP inhibitor that effectively treats mCRPC. The proposed studies are built upon: (1) an urgent and unmet medical need to develop new interventions for lethal mCRPC, (2) an imperative need to identify new therapeutic targets in mCRPC; and (3) strong preclinical evidence supporting GH501 as a novel and effective inhibitor of mCRPC. The overall objective is to conduct Investigational New Drug (IND)- enabling toxicology and efficacy studies on GH501 as a drug candidate for the treatment of lethal mCRPC. In Aim 1, we will develop an oral formulation of GH501 and test the hypothesis that GH501 has excellent safety and drug-like properties in preclinical models. In Aim 2, we will validate the mechanism of action of GH501 and test the hypothesis that as a novel Skp1 inhibitor, GH501 is efficacious against mCRPC in clinically-relevant xenograft models. Completion of the proposed project and follow-up preclinical studies will allow us to prepare an IND application within the next 3~4 years to advance GH501 into human trials. This highly innovative, translational project could have a significant impact in reducing prostate cancer mortality and morbidity.

转移性去势抵抗性前列腺癌（mCRPC）是致命的，无法治愈。尽管目前的治疗方法