Cancer Bioinformatics Services

癌症生物信息学服务

基本信息

批准号：
10474506
负责人：
Riyue Bao
金额：
$ 51.25万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-09-10 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10474506
关键词：
ATAC-seq Agreement Attention Award Big Data Bioinformatics Biometry Budgets Cancer Center Cancer Center Support Grant Cells ChIP-seq Collaborations Custom DNA methylation profiling Data Data Analyses Data Coordinating Center Data Science Data Sources Development Educational process of instructing Ensure Faculty Foundations Funding Genomics Health Health Science Library High Performance Computing Hour Immunogenetics Individual Infrastructure Institutes Internet Laboratories Malignant Neoplasms Malignant neoplasm of lung Metadata Metagenomics Metastatic breast cancer Molecular Biology Pathology Play Policies Postdoctoral Fellow Process Reproducibility Research Research Personnel Resource Sharing Role Services Shotguns Skin Cancer Specialized Program of Research Excellence Students Supercomputing System The Cancer Genome Atlas Time Tissues Universities Work anticancer research biological specimen archives biomedical informatics cancer genome cancer genomics computer infrastructure cost cost effective data integration data mining data privacy data sharing exome genome resource genome sequencing genomic data informatics tool machine learning algorithm malignant breast neoplasm member microbiome microbiome analysis precision medicine predictive marker recruit repository single-cell RNA sequencing tool transcriptome sequencing transcriptomics variant detection whole genome

项目摘要

Abstract: Cancer Bioinformatics Services (CBS) The complexity of cancer genome studies—from whole exome, whole genome, methylation, and RNA sequencing to emerging applications such as single cell and immunogenetic sequencing—poses significant challenges in data analysis and computing. The aim of the Cancer Bioinformatics Services (CBS) is to assist Hillman Cancer Center (HCC) investigators with bioinformatics data analysis, provide high performance computing and storage, and create high-value data sources such as the regulatory compliant local repository of TCGA data known as Pittsburgh Genome Resource Repository. CBS, with scientific support from the Department of Biomedical Informatics (DBMI), is co-directed by Drs. Chandran and Bao, and includes two full- time master’s level analysts and partial effort for several additional analysts. CBS supports all genomics studies from individual investigator projects to collaborative and consortia projects with expertise in genomic analysis, metadata annotation, data integration, HPC computing, genomics data privacy and data sharing policies. CBS is a highly collaborative effort involving CBS staff, DBMI faculty, the Pittsburgh Supercomputing Center (an NSF infrastructure), the University of Pittsburgh’s Center for Research Computing, the Institute of Precision Medicine, and the Health Science Library System’s Molecular Biology Service. In addition, CBS works closely with other HCC shared resources including the Biostatistics Facility, Cancer Genomics Facility, and Tissue and Research Pathology Services.

摘要：癌症生物信息学服务（CBS）癌症基因组研究的复杂性 - 从整个外显子，全基因组，甲基化和RNA 测序到新兴应用，例如单细胞和免疫发生测序 - 构成显着的数据分析和计算中的挑战。癌症生物信息学服务（CBS）的目的是协助具有生物信息学数据分析的希尔曼癌症中心（HCC）研究人员，提供高性能计算和存储，并创建高价值数据源，例如符合法规的本地存储库 TCGA数据称为匹兹堡基因组资源存储库。哥伦比亚广播公司，在科学的支持下生物医学信息学部（DBMI）由Drs共同执导。 Chandran和Bao，包括两个完整的时间硕士的水平分析师和其他几位分析师的部分努力。 CBS支持所有基因组学各个研究者项目的研究到具有基因组专业知识的协作和财团项目分析，元数据注释，数据集成，HPC计算，基因组学数据隐私和数据共享政策。 CBS是CBS员工，DBMI教职员工，匹兹堡超级计算中心（NSF基础设施），匹兹堡大学研究计算中心，研究所精密医学和健康科学图书馆系统的分子生物学服务。另外，CBS 与其他HCC共享资源紧密合作，包括生物统计学设施，癌症基因组学设施，以及组织与研究病理学服务。