Cancer Bioinformatics Services

摘要：癌症生物信息学服务(CBS) 癌症基因组研究的复杂性--从整个外显子组、全基因组、甲基化和RNA 测序对单细胞和免疫遗传测序等新兴应用具有重要意义 数据分析和计算方面的挑战。癌症生物信息学服务(CBS)的目的是帮助 希尔曼癌症中心(HCC)的研究人员通过生物信息学数据分析，提供高性能 计算和存储，并创建高价值数据源，如合规的本地存储库 称为匹兹堡基因组资源库的TCGA数据。哥伦比亚广播公司，在科学支持下 生物医学信息学系(DBMI)，由Chandran博士和Bao博士共同指导，包括两个完整的- 时间大师级别的分析师和额外几名分析师的部分努力。哥伦比亚广播公司支持所有基因组学 从个体研究者项目到具有基因组专业知识的合作和联盟项目的研究 分析、元数据注释、数据集成、高性能计算、基因组数据隐私和数据共享 政策。CBS是一项高度协作的工作，包括CBS工作人员、DBMI教员、匹兹堡超级计算 中心(NSF基础设施)、匹兹堡大学研究计算中心、 精确医学和健康科学图书馆系统的分子生物学服务。此外，哥伦比亚广播公司 与其他HCC共享资源密切合作，包括生物统计设施、癌症基因组学设施、 以及组织和研究病理学服务。

Abstract: Cancer Bioinformatics Services (CBS) The complexity of cancer genome studies—from whole exome, whole genome, methylation, and RNA sequencing to emerging applications such as single cell and immunogenetic sequencing—poses significant challenges in data analysis and computing. The aim of the Cancer Bioinformatics Services (CBS) is to assist Hillman Cancer Center (HCC) investigators with bioinformatics data analysis, provide high performance computing and storage, and create high-value data sources such as the regulatory compliant local repository of TCGA data known as Pittsburgh Genome Resource Repository. CBS, with scientific support from the Department of Biomedical Informatics (DBMI), is co-directed by Drs. Chandran and Bao, and includes two full- time master’s level analysts and partial effort for several additional analysts. CBS supports all genomics studies from individual investigator projects to collaborative and consortia projects with expertise in genomic analysis, metadata annotation, data integration, HPC computing, genomics data privacy and data sharing policies. CBS is a highly collaborative effort involving CBS staff, DBMI faculty, the Pittsburgh Supercomputing Center (an NSF infrastructure), the University of Pittsburgh’s Center for Research Computing, the Institute of Precision Medicine, and the Health Science Library System’s Molecular Biology Service. In addition, CBS works closely with other HCC shared resources including the Biostatistics Facility, Cancer Genomics Facility, and Tissue and Research Pathology Services.