Cancer Bioinformatics Services

癌症生物信息学服务

• 批准号: 10674796
• 负责人: Riyue Bao
• 金额: $ 51.25万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-10 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10674796
• 关键词: ATAC-seq; Agreement; Attention; Award; Big Data; Bioinformatics; Biometry; Budgets; Cancer Center; Cancer Center Support Grant; Cells; ChIP-seq; Collaborations; Custom; DNA methylation profiling; Data; Data Analyses; Data Coordinating Center; Data Science; Data Sources; Development; Educational process of instructing; Ensure; Faculty; Foundations; Funding; Genomics; Health; Health Science Library; High Performance Computing; Hour; Immunogenetics; Individual; Infrastructure; Institution; Internet; Laboratories; Malignant Neoplasms; Malignant neoplasm of lung; Metadata; Metagenomics; Metastatic breast cancer; Molecular Biology; Pathology; Play; Policies; Postdoctoral Fellow; Process; Reproducibility; Research; Research Personnel; Resource Sharing; Role; Services; Shotguns; Skin Cancer; Specialized Program of Research Excellence; Specimen; Students; Supercomputing; System; The Cancer Genome Atlas; Tissues; Universities; Work; anticancer research; biomedical informatics; cancer genome; cancer genomics; computer infrastructure; cost; cost effective; data integration; data mining; data privacy; data sharing; exome; genome resource; genome sequencing; genomic data; informatics tool; machine learning algorithm; malignant breast neoplasm; member; microbiome; microbiome analysis; precision medicine; predictive marker; recruit; repository; single-cell RNA sequencing; tool; transcriptome sequencing; transcriptomics; variant detection; whole genome

Abstract: Cancer Bioinformatics Services (CBS) The complexity of cancer genome studies—from whole exome, whole genome, methylation, and RNA sequencing to emerging applications such as single cell and immunogenetic sequencing—poses significant challenges in data analysis and computing. The aim of the Cancer Bioinformatics Services (CBS) is to assist Hillman Cancer Center (HCC) investigators with bioinformatics data analysis, provide high performance computing and storage, and create high-value data sources such as the regulatory compliant local repository of TCGA data known as Pittsburgh Genome Resource Repository. CBS, with scientific support from the Department of Biomedical Informatics (DBMI), is co-directed by Drs. Chandran and Bao, and includes two full- time master’s level analysts and partial effort for several additional analysts. CBS supports all genomics studies from individual investigator projects to collaborative and consortia projects with expertise in genomic analysis, metadata annotation, data integration, HPC computing, genomics data privacy and data sharing policies. CBS is a highly collaborative effort involving CBS staff, DBMI faculty, the Pittsburgh Supercomputing Center (an NSF infrastructure), the University of Pittsburgh’s Center for Research Computing, the Institute of Precision Medicine, and the Health Science Library System’s Molecular Biology Service. In addition, CBS works closely with other HCC shared resources including the Biostatistics Facility, Cancer Genomics Facility, and Tissue and Research Pathology Services.

翻译后摘要：癌症生物信息学服务（CBS） 癌症基因组研究的复杂性-从整个外显子组，全基因组，甲基化和RNA 测序的新兴应用，如单细胞和免疫遗传测序， 数据分析和计算方面的挑战。癌症生物信息学服务（CBS）的目的是帮助 希尔曼癌症中心（HCC）的研究人员与生物信息学数据分析，提供高性能 计算和存储，并创建高价值的数据源，如符合法规的本地存储库 被称为匹兹堡基因组资源库的TCGA数据。哥伦比亚广播公司，在科学支持下， 生物医学信息学系（DBMI），由Drs. Drs. 时间硕士水平的分析师和几个额外的分析师的部分工作。CBS支持所有基因组学 从个体研究者项目到具有基因组学专业知识的合作和联盟项目的研究 分析、元数据注释、数据集成、HPC计算、基因组学数据隐私和数据共享 施政纲要而CBS是一个高度合作的努力，涉及CBS的工作人员，DBMI教师，匹兹堡超级计算 中心（NSF基础设施）、匹兹堡大学研究计算中心、 精准医学和健康科学图书馆系统的分子生物学服务。此外，CBS 与其他HCC共享资源密切合作，包括生物统计学设施，癌症基因组学设施， 组织和研究病理学服务。