Neuropathology Core

神经病理学核心

• 批准号: 10475183
• 负责人: BERNARDINO Francesco GHETTI
• 金额: $ 35.23万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10475183
• 关键词: Affect; Alzheimer' s Disease; Alzheimer' s disease related dementia; Archives; Astrocytes; Autopsy; Biochemical; Biological; Biotechnology; Brain; Clinical; Collaborations; Collection; Communities; Confocal Microscopy; Continuing Education; Cryoelectron Microscopy; DNA analysis; Data; Dementia; Development; Diagnosis; Diagnostic; Diagnostics Research; Disease; Education; Electron Microscopy; Etiology; Evolution; Extracellular Protein; Family member; Formalin; Genetic; Genetic Markers; Genotype; Goals; Haplotypes; Heterogeneity; Histology; Human; Image Analysis; Immunofluorescence Immunologic; Immunohistochemistry; Indiana; Individual; Inherited; Institution; International; Label; Laboratories; Lesion; Libraries; Liquid substance; Longitudinal Studies; Measures; Medical Students; Medicine; Methods; Microglia; Mission; Molecular; Molecular Conformation; Molecular Genetics; Morphology; Nerve Degeneration; Neurodegenerative Disorders; Neurons; Paraffin Embedding; Pathogenesis; Pathologic; Pathology; Patients; Phenotype; Physicians; Proteins; Quality Control; RNA; Research; Research Methodology; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Risk Factors; Schedule; Single Nucleotide Polymorphism; Structure; Tissue Banks; Tissue Harvesting; Tissue Sample; Tissues; United States National Institutes of Health; Universities; brain tissue; demented; digital imaging; early onset; imaging biomarker; insight; interdisciplinary approach; interest; laboratory facility; lectures; molecular marker; neurodegenerative dementia; neuroimaging; neuropathology; next generation sequencing; novel; novel diagnostics; novel marker; precision medicine; programs; recruit; research and development; symposium; tau Proteins

Project Summary – Neuropathology Core (NPC) The Neuropathology Core (NPC) provides professional expertise for the diagnosis of tissue obtained at autopsy from patients with dementia and from control subjects, recruited by the Clinical Core (CC) of the Indiana Alzheimer’s Disease Research Center (IADRC). The NPC will also provide information about pathologic data to referring physicians, patients’ family members, and basic researchers. In addition, the NPC will be involved in providing continuing education to physicians, researchers, technicians, and the community, about new developments emerging from AD and related dementia research. Laboratory facilities and technical resources are available for the collection, and storage of human CNS tissue. Brain tissue of demented individuals is studied for diagnostic and research purposes using a multidisciplinary approach. The NPC combines data obtained by neurohistology, and immunohistochemistry to reveal the presence of abnormal proteins and determine their localization through the CNS. The NPC has expanded its mission by integrating genetics with neuropathology. Such integration is fundamental to understand disease etiology, pathogenesis and phenotypic heterogeneity. This multidisciplinary approach is the hallmark of the IADRC’s NPC and contributes to providing a definitive diagnosis of dementing disorders. The NPC supports numerous national and international scientific programs, providing scientific insights along with tissue samples from the brain library. Results from studies carried out by investigators of the NPC are presented at national and international conferences, including the annual Alzheimer Association International Conference (AAIC). In the study of patients with dementia, the concept of precision medicine is best applied through the interaction of the NPC with the CC, the Neuroimaging Core, the Genetics, Biomarker, and Biospecimen Core and the Data Core.

项目摘要 - 神经病理学核心（NPC） 神经病理学核心（NPC）为诊断组织提供了专业知识 从痴呆症患者和对照组患者进行尸检，由 印第安纳州阿尔茨海默氏病研究中心（IADRC）的临床核心（CC）。 NPC会 还向转诊医师，患者的家庭成员提供有关病理数据的信息， 和基础研究人员。此外，NPC将参与提供继续教育 有关新发展的医师，研究人员，技术人员和社区 来自AD和相关痴呆研究。实验室设施和技术资源是 可用于收集和存储人CNS组织。 痴呆个体的脑组织是研究诊断和研究目的的研究。 多学科方法。 NPC结合了通过神经组织学获得的数据，以及 免疫组织化学以揭示异常蛋白的存在并确定其 通过中枢神经系统进行定位。 NPC通过将遗传学与 神经病理学。这种整合对于理解病因，发病机理至关重要 和表型异质性。这种多学科方法是IADRC的标志 NPC并有助于提供痴呆症的明确诊断。 NPC 支持众多国家和国际科学计划，提供科学见解 以及来自大脑文库的组织样品。由研究的结果 NPC的调查人员在包括 年度阿尔茨海默氏症国际会议（AAIC）。在研究患者 痴呆症，精确医学的概念最好通过NPC的相互作用来应用 与CC，神经影像核，遗传学，生物标志物和生物晶体核心以及 数据核心。