Neuropathology Core

神经病理学核心

• 批准号: 10475183
• 负责人: BERNARDINO Francesco GHETTI
• 金额: $ 35.23万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10475183
• 关键词: Affect; Alzheimer' s Disease; Alzheimer' s disease related dementia; Archives; Astrocytes; Autopsy; Biochemical; Biological; Biotechnology; Brain; Clinical; Collaborations; Collection; Communities; Confocal Microscopy; Continuing Education; Cryoelectron Microscopy; DNA analysis; Data; Dementia; Development; Diagnosis; Diagnostic; Diagnostics Research; Disease; Education; Electron Microscopy; Etiology; Evolution; Extracellular Protein; Family member; Formalin; Genetic; Genetic Markers; Genotype; Goals; Haplotypes; Heterogeneity; Histology; Human; Image Analysis; Immunofluorescence Immunologic; Immunohistochemistry; Indiana; Individual; Inherited; Institution; International; Label; Laboratories; Lesion; Libraries; Liquid substance; Longitudinal Studies; Measures; Medical Students; Medicine; Methods; Microglia; Mission; Molecular; Molecular Conformation; Molecular Genetics; Morphology; Nerve Degeneration; Neurodegenerative Disorders; Neurons; Paraffin Embedding; Pathogenesis; Pathologic; Pathology; Patients; Phenotype; Physicians; Proteins; Quality Control; RNA; Research; Research Methodology; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Risk Factors; Schedule; Single Nucleotide Polymorphism; Structure; Tissue Banks; Tissue Harvesting; Tissue Sample; Tissues; United States National Institutes of Health; Universities; brain tissue; demented; digital imaging; early onset; imaging biomarker; insight; interdisciplinary approach; interest; laboratory facility; lectures; molecular marker; neurodegenerative dementia; neuroimaging; neuropathology; next generation sequencing; novel; novel diagnostics; novel marker; precision medicine; programs; recruit; research and development; symposium; tau Proteins

Project Summary – Neuropathology Core (NPC) The Neuropathology Core (NPC) provides professional expertise for the diagnosis of tissue obtained at autopsy from patients with dementia and from control subjects, recruited by the Clinical Core (CC) of the Indiana Alzheimer’s Disease Research Center (IADRC). The NPC will also provide information about pathologic data to referring physicians, patients’ family members, and basic researchers. In addition, the NPC will be involved in providing continuing education to physicians, researchers, technicians, and the community, about new developments emerging from AD and related dementia research. Laboratory facilities and technical resources are available for the collection, and storage of human CNS tissue. Brain tissue of demented individuals is studied for diagnostic and research purposes using a multidisciplinary approach. The NPC combines data obtained by neurohistology, and immunohistochemistry to reveal the presence of abnormal proteins and determine their localization through the CNS. The NPC has expanded its mission by integrating genetics with neuropathology. Such integration is fundamental to understand disease etiology, pathogenesis and phenotypic heterogeneity. This multidisciplinary approach is the hallmark of the IADRC’s NPC and contributes to providing a definitive diagnosis of dementing disorders. The NPC supports numerous national and international scientific programs, providing scientific insights along with tissue samples from the brain library. Results from studies carried out by investigators of the NPC are presented at national and international conferences, including the annual Alzheimer Association International Conference (AAIC). In the study of patients with dementia, the concept of precision medicine is best applied through the interaction of the NPC with the CC, the Neuroimaging Core, the Genetics, Biomarker, and Biospecimen Core and the Data Core.

项目摘要-神经病理学核心（NPC） 神经病理学核心（NPC）为组织诊断提供专业知识 从痴呆患者和对照受试者的尸检中获得， 印第安纳州阿尔茨海默病研究中心（IADRC）的临床核心（CC）。全国人大都 还向转诊医生，患者家属， 基础研究人员。此外，全国人民代表大会将参与为以下人员提供继续教育： 医生，研究人员，技术人员和社区，关于新的发展出现 AD和相关痴呆症的研究。实验室设施和技术资源 可用于收集和储存人CNS组织。 为了诊断和研究的目的，使用 多学科方法。NPC结合了神经组织学获得的数据， 免疫组化以揭示异常蛋白质的存在并确定其 通过CNS定位。NPC通过将遗传学与 神经病理学这种整合是理解疾病病因、发病机制的基础 和表型异质性。这种多学科方法是IADRC的标志， NPC和有助于提供痴呆症的明确诊断。全国人大 支持众多国家和国际科学计划，提供科学见解 沿着的还有大脑库的组织样本。研究结果由 全国人民代表大会的调查人员出席国家和国际会议，包括 阿尔茨海默病协会国际会议（AAIC）在研究中， 痴呆症，精准医疗的概念最好通过NPC的互动来应用。 与CC，神经影像核心，遗传学，生物标志物和生物标本核心和 数据核心。