Neuropathology Core

神经病理学核心

• 批准号: 10475183
• 负责人: BERNARDINO Francesco GHETTI
• 金额: $ 35.23万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10475183
• 关键词: Affect; Alzheimer' s Disease; Alzheimer' s disease related dementia; Archives; Astrocytes; Autopsy; Biochemical; Biological; Biotechnology; Brain; Clinical; Collaborations; Collection; Communities; Confocal Microscopy; Continuing Education; Cryoelectron Microscopy; DNA analysis; Data; Dementia; Development; Diagnosis; Diagnostic; Diagnostics Research; Disease; Education; Electron Microscopy; Etiology; Evolution; Extracellular Protein; Family member; Formalin; Genetic; Genetic Markers; Genotype; Goals; Haplotypes; Heterogeneity; Histology; Human; Image Analysis; Immunofluorescence Immunologic; Immunohistochemistry; Indiana; Individual; Inherited; Institution; International; Label; Laboratories; Lesion; Libraries; Liquid substance; Longitudinal Studies; Measures; Medical Students; Medicine; Methods; Microglia; Mission; Molecular; Molecular Conformation; Molecular Genetics; Morphology; Nerve Degeneration; Neurodegenerative Disorders; Neurons; Paraffin Embedding; Pathogenesis; Pathologic; Pathology; Patients; Phenotype; Physicians; Proteins; Quality Control; RNA; Research; Research Methodology; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Risk Factors; Schedule; Single Nucleotide Polymorphism; Structure; Tissue Banks; Tissue Harvesting; Tissue Sample; Tissues; United States National Institutes of Health; Universities; brain tissue; demented; digital imaging; early onset; imaging biomarker; insight; interdisciplinary approach; interest; laboratory facility; lectures; molecular marker; neurodegenerative dementia; neuroimaging; neuropathology; next generation sequencing; novel; novel diagnostics; novel marker; precision medicine; programs; recruit; research and development; symposium; tau Proteins

Project Summary – Neuropathology Core (NPC) The Neuropathology Core (NPC) provides professional expertise for the diagnosis of tissue obtained at autopsy from patients with dementia and from control subjects, recruited by the Clinical Core (CC) of the Indiana Alzheimer’s Disease Research Center (IADRC). The NPC will also provide information about pathologic data to referring physicians, patients’ family members, and basic researchers. In addition, the NPC will be involved in providing continuing education to physicians, researchers, technicians, and the community, about new developments emerging from AD and related dementia research. Laboratory facilities and technical resources are available for the collection, and storage of human CNS tissue. Brain tissue of demented individuals is studied for diagnostic and research purposes using a multidisciplinary approach. The NPC combines data obtained by neurohistology, and immunohistochemistry to reveal the presence of abnormal proteins and determine their localization through the CNS. The NPC has expanded its mission by integrating genetics with neuropathology. Such integration is fundamental to understand disease etiology, pathogenesis and phenotypic heterogeneity. This multidisciplinary approach is the hallmark of the IADRC’s NPC and contributes to providing a definitive diagnosis of dementing disorders. The NPC supports numerous national and international scientific programs, providing scientific insights along with tissue samples from the brain library. Results from studies carried out by investigators of the NPC are presented at national and international conferences, including the annual Alzheimer Association International Conference (AAIC). In the study of patients with dementia, the concept of precision medicine is best applied through the interaction of the NPC with the CC, the Neuroimaging Core, the Genetics, Biomarker, and Biospecimen Core and the Data Core.

项目摘要-神经病理学核心(NPC) 神经病理学核心(NPC)为组织诊断提供专业知识 从痴呆症患者和对照受试者的尸检中获得，由 印第安纳州阿尔茨海默病研究中心(IADRC)的临床核心(CC)。全国人大将 还提供有关病理数据的信息给转介医生、患者家属、 和基础研究人员。此外，全国人大将参与提供持续教育，以 医生、研究人员、技术人员和社区，了解正在出现的新发展 来自AD和相关痴呆症的研究。实验室设施和技术资源 可用于人体中枢神经系统组织的收集、储存。 为了诊断和研究目的，对痴呆患者的脑组织进行了研究 多学科方法。全国人大结合了神经组织学获得的数据，以及 免疫组织化学显示异常蛋白的存在并确定其 通过CNS实现本地化。全国人大扩大了其使命，将遗传学与 神经病理学。这种整合是理解疾病病因、发病机制的基础 表型异质性。这种多学科的方法是IADRC的标志 鼻咽癌，并有助于提供痴呆障碍的明确诊断。全国人大 支持众多国家和国际科学计划，提供科学见解 以及来自脑库的组织样本。由以下机构进行的研究结果 全国人大调查人员出席国内和国际会议，包括 阿尔茨海默病协会国际年会(AAIC)。在对慢性阻塞性肺疾病患者的研究中 痴呆症，精准医学的概念最好通过全国人大的互动来应用 与CC、神经成像核心、遗传学、生物标记物和Biospecimen核心以及 数据核心。