Neuropathology Core

神经病理学核心

• 批准号: 10264433
• 负责人: BERNARDINO Francesco GHETTI
• 金额: $ 35.71万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10264433
• 关键词: Affect; Alzheimer' s Disease; Alzheimer' s disease related dementia; Archives; Astrocytes; Autopsy; Biochemical; Biological; Biotechnology; Brain; Clinical; Collaborations; Collection; Communities; Confocal Microscopy; Continuing Education; Cryoelectron Microscopy; DNA analysis; Data; Dementia; Development; Diagnosis; Diagnostic; Diagnostics Research; Disease; Education; Electron Microscopy; Etiology; Evolution; Extracellular Protein; Family member; Formalin; Genetic; Genetic Markers; Genotype; Goals; Haplotypes; Heterogeneity; Histology; Human; Image Analysis; Immunofluorescence Immunologic; Immunohistochemistry; Indiana; Individual; Inherited; Institution; International; Label; Laboratories; Lesion; Libraries; Liquid substance; Longitudinal Studies; Measures; Medical Students; Medicine; Methods; Microglia; Mission; Molecular; Molecular Conformation; Molecular Genetics; Morphology; Nerve Degeneration; Neurodegenerative Disorders; Neurons; Paraffin Embedding; Pathogenesis; Pathologic; Pathology; Patients; Phenotype; Physicians; Proteins; Quality Control; RNA; Research; Research Methodology; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Risk Factors; Schedule; Single Nucleotide Polymorphism; Structure; Tissue Banks; Tissue Harvesting; Tissue Sample; Tissues; United States National Institutes of Health; Universities; brain tissue; demented; digital imaging; early onset; imaging biomarker; insight; interdisciplinary approach; interest; laboratory facility; lectures; molecular marker; neurodegenerative dementia; neuroimaging; neuropathology; next generation sequencing; novel; novel diagnostics; novel marker; precision medicine; programs; recruit; research and development; symposium; tau Proteins

Project Summary – Neuropathology Core (NPC) The Neuropathology Core (NPC) provides professional expertise for the diagnosis of tissue obtained at autopsy from patients with dementia and from control subjects, recruited by the Clinical Core (CC) of the Indiana Alzheimer’s Disease Research Center (IADRC). The NPC will also provide information about pathologic data to referring physicians, patients’ family members, and basic researchers. In addition, the NPC will be involved in providing continuing education to physicians, researchers, technicians, and the community, about new developments emerging from AD and related dementia research. Laboratory facilities and technical resources are available for the collection, and storage of human CNS tissue. Brain tissue of demented individuals is studied for diagnostic and research purposes using a multidisciplinary approach. The NPC combines data obtained by neurohistology, and immunohistochemistry to reveal the presence of abnormal proteins and determine their localization through the CNS. The NPC has expanded its mission by integrating genetics with neuropathology. Such integration is fundamental to understand disease etiology, pathogenesis and phenotypic heterogeneity. This multidisciplinary approach is the hallmark of the IADRC’s NPC and contributes to providing a definitive diagnosis of dementing disorders. The NPC supports numerous national and international scientific programs, providing scientific insights along with tissue samples from the brain library. Results from studies carried out by investigators of the NPC are presented at national and international conferences, including the annual Alzheimer Association International Conference (AAIC). In the study of patients with dementia, the concept of precision medicine is best applied through the interaction of the NPC with the CC, the Neuroimaging Core, the Genetics, Biomarker, and Biospecimen Core and the Data Core.

项目摘要-神经病理学核心（NPC）